2011 Fiscal Year Final Research Report
Creations of Dynamical Guiding Principle of Selectivity and Stochasticity across Spatiotemporal Hierarchy in Biological Functions
| Project/Area Number |
21340117
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics/Chemical physics
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
LI Chun-biu 北海道大学, 電子科学研究所, 准教授 (90397795)
TERAMOTO Hiroshi 北海道大学, 電子科学研究所, 助教 (90463728)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 1分子計測(SMD) / 化学物理 / 生物物理 / ネットワーク / 生体分子 |
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| Research Abstract |
To the fundamental question of how molecular functions persist its selectivity under influence of thermal fluctuation, we revealed that one can predict analytically the reaction fate or structural change by a nonlinear coordinate transformation involving the velocities of the system and the friction and random force exerted by thermal degrees of freedom, transition state can change dynamically at high energy/temperature regimes, and developed a new theory that enables us to derive an effective energy landscape from hierarchical state space transition network derived from single molecule time series.
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