2011 Fiscal Year Final Research Report
Synthesis of Metal Complexes that can function in an Aqueous Solution Aiming at Application to Chemical Biology
| Project/Area Number |
21350037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HITOMI Yutaka 同志社大学, 理工学部, 准教授 (20335186)
FUNABIKI Takuzo 同志社大学, 理工学部, RCAST研究員 (70026061)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 分子生命化学 / バイオインスパイアード錯体 / メタンモノオキシゲナーゼ / 酸素活性化 / P⇔Q変換 / carboxylate-rich coordination environment / 水の酸化による酸素発生 |
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| Research Abstract |
For the purpose of developing bio-inspired metal complexes applicable to chemical biology, we synthesized metal complexes with newly designed various ligands that specifically stabilize the structures of the metal complexes in solution. With the metal complexes, we successfully attained following biologically relevant functions, (1) mimicking P-to-Q conversion in the O_2-activation of soluble methane monooxygenase(sMMO), (2) roles of the carboxylate-rich coordination environment in O_2-activating diiron enzymes, and (3) enhancement of catalytic activity of ruthenium complexes for O_2-evolution by water oxidation as a model of oxygen evolution complex(OEC). In these systems, we found that stabilization of the optimal structures for the functions in solution leads to enhancement of the functionality, essential for developing effective bio-inspired metal complexes.
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[Journal Article] An in situ quick XAFS spectroscopy study on the formation mechanism of small gold nanoparticles supported by porphyrin-cored tetradentate passivants2011
Author(s)
Junya Ohyama, Kentaro Teramura, Yasuhiro Higuchi, Tetsuya Shishido, Yutaka Hitomi, Kazuki Aoki, Takuzo Funabiki, Masahito Kodera Kazuo Kato, Hajime Tanida, Tomoya Uruga, Tsunehiro Tanaka
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Journal Title
Phys. Chem. Chem. Phys
Volume: 13
Pages: 11128-11135
Peer Reviewed
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