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2011 Fiscal Year Final Research Report

Capture of diatomic molecules by supramolecular heme protein models and application to development to medicinal chemistry

Research Project

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Project/Area Number 21350097
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemistry related to living body
Research InstitutionDoshisha University

Principal Investigator

KANO Koji  同志社大学, 理工学部, 教授 (60038031)

Co-Investigator(Kenkyū-buntansha) NEGI Shigeru  同志社女子大学, 薬学部, 助手 (50378866)
KAWAGUCHI Akira  東海大学, 医学部, 准教授 (30195052)
Project Period (FY) 2009 – 2011
Keywords超分子化学 / ナノバイオ / ヘムタンパク質
Research Abstract

HemoCD, which is composed of a water-soluble iron porphyrin(FeTPPS) and a per-methylated β-cyclodextrin dimer(Py3CD), was attached to poly(acrylic acid) s or gold nano-particles to inhibit glomerular filtration of hemoCD. These modified hemoCDs, which were regarded as the hemoglobin(Hb) and myoglobin(Mb) models, were not excluded in the urine of a rat, suggesting that the modified hemoCDs stay in the blood for a long time. We also tried to apply the present supramolecular system to medicinal chemistry. At first, the removal of endogenous carbon monoxide of a rat was examined by infusing hemoCD solution into the femoral vein. Injected hemoCD was rapidly excreted in the urine in the form of a carbon monoxide adduct, indicating that hemoCD can be used as an antidote of CO poisoning. Meanwhile, hemoCD was unfavorable for the cyanide poisoning. Then we prepared a supramolecule, Im3CD/Fe(III) TPPS complex, which strongly captured the cyanide anion in a rat's body. Since this cyanide remover did not interact with bovine proteins, the Im3CD/Fe(III) TPPS complex was assumed to be better antidote than hydroxocobalamin.

  • Research Products

    (17 results)

All 2012 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (5 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Kitagishi, Supramolecular dioxygen receptors composed of an anionic water-soluble porphinatoiron(II) and cyclodextrin dimers2012

    • Author(s)
      K. Kano, S. Chimoto, M. Tamaki, Y. Itoh, H.
    • Journal Title

      Dalton Trans

      Volume: Vol.41 Pages: 453-461

    • Peer Reviewed
  • [Journal Article] Supramolecular Ferric Porphyrins as Cyanide Receptors in Aqueous Solution2011

    • Author(s)
      K. Watanabe, H. Kitagishi, K. Kano
    • Journal Title

      ACS Med. Chem. Lett

      Volume: Vol.2 Pages: 943-947

    • Peer Reviewed
  • [Journal Article] Preparation and Function of Poly(acrylic acid) s Modified by Supramolecular Complex Composed of Porphinatoiron and a Cyclodextrin Dimer That Binds Diatomic Molecules(O_2 and CO) in Aqueous Solution2011

    • Author(s)
      K. Kano, T. Ochi, S. Okunaka, Y. Ota, K. Karasugi, T. Ueda, H. Kitagishi
    • Journal Title

      Chem. Asian J

      Volume: Vol.6 Pages: 2946-2955

    • Peer Reviewed
  • [Journal Article] Gold Nanoparticles Carrying Diatomic Molecules(O2 and CO) in Aqueous Solution2011

    • Author(s)
      K. Karasugi, H. Kitagishi, K. Kano
    • Journal Title

      Chem. Asian J

      Volume: Vol.6 Pages: 825-833

    • Peer Reviewed
  • [Journal Article] Time-Dependent Enzyme Activity Dominated by Dissociation of J-Aggregates Bound to Protein Surface2010

    • Author(s)
      K. Watanabe, K. Kano
    • Journal Title

      Bioconjugate Chemistry

      Volume: Vol.21 Pages: 2332-2338

    • Peer Reviewed
  • [Journal Article] Oxoferryl Porphyrin/Hydrogen Peroxide System Whose Behavior is Equivalent to Hydroperoxoferric Porphyrin2010

    • Author(s)
      H. Kitagishi, M. Tamaki, T. Ueda, S. Hirota, T. Ohta, Y. Naruta, K. Kano
    • Journal Title

      J. Am. Chem. Soc

      Volume: Vol.132 Pages: 16730-16732

    • Peer Reviewed
  • [Journal Article] A Diatomic Molecule Receptor That Removes CO in a Living Organism2010

    • Author(s)
      H. Kitagishi, S. Negi, A. Kiriyama, A. Honbo, Y. Sugiura, A. T. Kawaguchi, K. Kano
    • Journal Title

      Angew. Chem. Int. Ed

      Volume: Vol.49 Pages: 1312-1315

    • Peer Reviewed
  • [Journal Article] HemoCD as an artificial oxygen carrier : oxygen binding and autoxidation2009

    • Author(s)
      K. Kano, H. Kitagishi
    • Journal Title

      Artif. Organs

      Volume: Vol.33 Pages: 177-182

    • Peer Reviewed
  • [Presentation] Cyclodextrin/iron porphyrin supramolecules as heme protein models2011

    • Author(s)
      K. Kano
    • Organizer
      II European Conference on Cyclodextrins
    • Place of Presentation
      Asti, Italy
    • Year and Date
      2011-10-04
  • [Presentation] Reactions of Ferric Porphyrin Encapsulated by Cyclodextrin Dimers with Hydrogen Peroxide2011

    • Author(s)
      K. Kano, H. Kitagishi, T. Ueda, T. Ohta, Y. Naruta
    • Organizer
      International Symposium on Activation of Dioxygen and Homogeneous Catalytic Oxidation
    • Place of Presentation
      Okinawa
    • Year and Date
      2011-06-05
  • [Presentation] Unique properties of heme-protein models composed of iron porphyrins and cyclodextrin dimers2010

    • Author(s)
      K. Kano, H. Kitagishi
    • Place of Presentation
      Pacifichem, Honolulu
    • Year and Date
      2010-12-17
  • [Presentation] Alkylperoxo-and Hydroperoxo-Ferric Porphyrins in Aqueous Solution2010

    • Author(s)
      K. Kano, H. Kitagishi, M. Tamaki, T. Ueda, S. Hirota, T. Ohta, Y. Naruta
    • Organizer
      Sixth International Conference on Porphyrins and Phthalocyanines
    • Place of Presentation
      New Mexico
    • Year and Date
      2010-07-06
  • [Presentation] What can we do if intramolecular hydrogen bonding of a cyclodextrin is eliminated?2009

    • Author(s)
      K. Kano
    • Organizer
      10th Latin American Conference on Physical Organic Chemistry
    • Place of Presentation
      Florianopolis, Brazil
    • Year and Date
      2009-10-14
  • [Book] 基本有機化学2009

    • Author(s)
      加納航治
    • Total Pages
      318
    • Publisher
      三共出版
  • [Remarks]

    • URL

      http://www1.doshisha.ac.jp/-kkano/

  • [Patent(Industrial Property Rights)] 一酸化炭素除去剤2011

    • Inventor(s)
      加納航治
    • Industrial Property Rights Holder
      学校法人同志社
    • Industrial Property Number
      特許、13/218, 100
    • Filing Date
      2011-08-25
    • Overseas
  • [Patent(Industrial Property Rights)] 人工血液酸素輸液2011

    • Inventor(s)
      加納航治・北岸宏亮
    • Industrial Property Rights Holder
      学校法人同志社
    • Industrial Property Number
      特許、特願2004-181125
    • Acquisition Date
      2011-08-19

URL: 

Published: 2013-07-31  

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