2011 Fiscal Year Final Research Report
Evaluation of the Degree of Maturation in the Regenerative Tissues by Analysis of Micro-Elastic Structure
| Project/Area Number |
21360123
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Intelligent mechanics/Mechanical systems
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
TAKAMIZAWA Keiichi 独立行政法人国立循環器病研究センター, 生体医工学部, 研究員 (10163312)
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| Co-Investigator(Kenkyū-buntansha) |
KANDA Keiichi 京都府立医科大学, 心臓血管外科, 講師 (60295649)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 再生医療 / 触覚顕微鏡 / 弾性率 / 生体組織 / 計測装置 |
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| Research Abstract |
We have been developed a scanning haptic microscope(SHM) for easy observation of the distribution of surface elasticity over a tissue slice sample. By improvement of SHM long time observation and wide area surface elasticity distribution imaging of the porcine arteries were enabled by soaking the sample in saline. Therefore, the differences in the elasticity under no load condition were revealed by visualization of local elastic structure at the extracellular matrix level in different segments of the canine aorta. SHM proved to be a powerful tool for precise evaluation of the degree of physical maturation after implantation of tissue-engineered tissues.
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Research Products
(24 results)
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[Journal Article] Water-soluble argatroban for antithrombogenic surface coating of tissue-engineered cardiovascular tissues2011
Author(s)
Nakayama Y, Yamaoka S, Yamanami M, Fujiwara M, Uechi M, Takamizawa K, Ishibashi-Ueda H, Nakamichi M, Uchida K, Watanabe T, Kanda K, Yaku H.
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Journal Title
J Biomed Mater Res B Appl Biomater
Volume: 99(2)
Pages: 420-30
DOI
Peer Reviewed
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[Journal Article] Development of a completely autologous valved conduit with the sinus of Valsalva using in-body tissue architecture technology : a pilot study in pulmonary valve replacement in a beagle model2010
Author(s)
Yamanami M, Yahata Y, Uechi M, Fujiwara M, Ishibashi-Ueda H, Kanda K, Watanabe T, Tajikawa T, Ohba K, Yaku H, Nakayama Y
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Journal Title
Circulation
Volume: 122(11)
Pages: S100-6
DOI
Peer Reviewed
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