A comprehensive study of the molecular mechanisms of associative learning by a behavioral genetic approach.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21370002
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Genetics/Genome dynamics
• Research Institution: The University of Tokyo
• Principal Investigator: IINO Yuichi 東京大学, 大学院・理学系研究科, 教授 (40192471)
• Project Period (FY): 2009 – 2011
• Keywords: 学習記憶 / 線虫C. elegans / 化学走性行動 / インスリン / PTEN / 左右非対称性 / PI3キナーゼ / カルシンテニン

Research Abstract

The nematode C. elegans learns to avoid salt after the experience of starvation in the presence of salt. A pair of sensory neurons sense salt, but only the right member of this pair changes by learning through the effect of the C. elegans insulin. In addition, a protein known to be relevant to Alzheimer's desease was found closely related to the action of the insulin signal.

Research Products

• [Journal Article] Neuronal plasticity regulated by theinsulin-like signaling pathway underliessalt chemotaxis learning in Caenorhabditiselegans (2011)
  • Author(s): Oda, S., Tomioka, M., and Iino, Y
  • Journal Title: J Neurophysiol Volume: VOL. 106 Pages: 301-308
  • Peer Reviewed
• [Journal Article] Roles for class IIA phosphatidylinositoltransfer protein in neurotransmission andbehavioral plasticity at the sensoryneuron synapses of Caenorhabditis elegans (2011)
  • Author(s): Iwata, R., Oda, S., Kunitomo, H., andIino, Y
  • Journal Title: Proc Natl Acad Sci USA Volume: VOL 108 Pages: 7589-7594
  • DOI: DOI:10.1073/pnas.1016232108
  • Peer Reviewed
• [Journal Article] Behavioral Choice between Conflicting Alternatives Is Regulated by a Receptor Guanylyl Cyclase, GCY-28, and a ReceptorTyrosine Kinase, SCD-2, in AIA Interneurons of Caenorhabditis elegans. (2011)
  • Author(s): Shinkai, Y., Yamamoto, Y., Fujiwara, M., Tabata, T., Murayama, T., Hirotsu, T., Ikeda, D. D., Tsunozaki, M., Iino, Y., Bargmann, C. I., Katsura, I., and Ishihara, T
  • Journal Title: J Neurosci Volume: 31 Pages: 3007-3015
  • DOI: DOI:10.1523/JNEUROSCI.4691-10.2011
  • Peer Reviewed
• [Journal Article] Insulin signaling plays a dual role in Caenorhabditis elegans memory acquisitionand memory retrieval (2010)
  • Author(s): Lin, C. H. A., Tomioka, M., Pereira, S., Sellings, L., Iino, Y., and van der Kooy, D.
  • Journal Title: Journal of Neuroscience Volume: 30 Pages: 8001-8011
  • DOI: DOI:10.1523/JNEUROSCI.4636-09.2010
  • Peer Reviewed
• [Journal Article] Identification of tubulin deglutamylaseamong Caenorhabditis elegans and mammaliancytosolic carboxypeptidases(CCPs) (2010)
  • Author(s): Kimura, Y., Kurabe, N., Ikegami, K., Tsutsumi, K., Konishi, Y., Kaplan, O. I., Kunitomo, H., Iino, Y., Blacque, O. E., and Setou, M
  • Journal Title: J Biol Chem Volume: 285 Pages: 22934-22939
  • DOI: DOI:10.1074/jbc.C110.128280
  • Peer Reviewed
• [Journal Article] Olfactory plasticity is regulated bypheromonal signaling in Caenorhabditiselegans (2010)
  • Author(s): Yamada, K., Hirotsu, T., Matsuki, M., Butcher, R. A., Tomioka, M., Ishihara, T., Clardy, J., Kunitomo, H., and Iino, Y
  • Journal Title: Science Volume: 329 Pages: 1647-1650
  • DOI: DOI:10.1126/science.1192020
  • Peer Reviewed
• [Journal Article] Reversal of Salt Preference Is Directed bythe Insulin/PI3K and Gq/PKC Signaling in Caenorhabditis elegans (2010)
  • Author(s): Adachi, T., Kunitomo, H., Tomioka, M., Ohno, H., Okochi, Y., Mori, I., and Iino, Y
  • Journal Title: Genetics Volume: 186 Pages: 1309-1319
  • Peer Reviewed
• [Journal Article] Single-cell transcriptional analysis of taste sensory neuron pair in Caenorhabditis elegans (2010)
  • Author(s): Takayama, J., Faumont, S., Kunitomo, H., Lockery, S. R., and Iino, Y
  • Journal Title: Nucleic Acids Research Volume: 38 Pages: 131-142
  • DOI: DOI:10.1093/nar/gkp868
  • Peer Reviewed
• [Journal Article] Lateralized gustatory behavior of C. elegans is controlled by specificreceptor-type guanylyl cyclases (2009)
  • Author(s): Ortiz, C. O., Faumont, S., Takayama, J., Ahmed, H. K., Goldsmith, A. D., Pocock, R., McCormick, K. E., Kunimoto, H., Iino, Y., Lockery, S., et al
  • Journal Title: Current Biology Volume: 19 Pages: 996-1004
  • DOI: DOI:10.1016/j.cub.2009.05.043
  • Peer Reviewed
• [Journal Article] A trophic role for Wnt-Ror kinasesignaling during developmentalpruning in Caenorhabditis elegans (2009)
  • Author(s): Hayashi, Y., Hirotsu, T., Iwata, R., Kage-Nakadai, E., Kunitomo, H., Ishihara, T., Iino, Y., and Kubo, T
  • Journal Title: Nature Neuroscience Volume: 12 Pages: 981-987
  • DOI: DOI:10.1038/nn.2347
  • Peer Reviewed
• [Presentation] Dynamics of neural activities underlying salt chemotaxis learning in C. elegans (2011)
  • Author(s): 小田茂和
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-13
• [Presentation] プロテインキナーゼCによる線虫の塩濃度学習の制御機構の解析 (2011)
  • Author(s): 田村成宏
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-13
• [Presentation] Analyses of molecular mechanisms of information ntegration in food-dependent salt chemotaxis learning in C. elegans (2011)
  • Author(s): 酒井奈緒子
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-13
• [Presentation] The role of insulin/PI3-kinase pathway in food-dependentplasticity of salt chemotaxis in C. elegans. (2011)
  • Author(s): 富岡征大
  • Organizer: Neuroscience 2011, SfN's 41st annual meeting
  • Place of Presentation: ワシントンDC
  • Year and Date: 2011-11-16
• [Presentation] Sensing Salt : Plasticity inSensory Systems and Behavioral Response (2011)
  • Author(s): 飯野雄一
  • Organizer: 18th international C. elegans meeting
  • Place of Presentation: ロサンゼルス
  • Year and Date: 2011-06-24
• [Presentation] Axonal transport of a new DAF-2 isoform governs associativelearning (2011)
  • Author(s): 大野速雄
  • Organizer: 18th international C. elegans meeting
  • Place of Presentation: ロサンゼルス
  • Year and Date: 2011-06-24
• [Presentation] Molecular pathways and neural circuit that underlie the plasticityof salt chemotaxis in C. elegans (2010)
  • Author(s): 飯野雄一
  • Organizer: BMB2010第33回日本分子生物学会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸・神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] 線虫C. elegansの学習を制御するインスリン様シグナル伝達経路の役割 (2010)
  • Author(s): 富岡征大
  • Organizer: 第81回日本動物学会大会
  • Place of Presentation: 東京・東京大学教養学部
  • Year and Date: 2010-09-24
• [Presentation] Pheromonal interactions modulate behavioral plasticity in C. elegans (2010)
  • Author(s): 飯野雄一
  • Organizer: 4th East Asia C. elegans Meeting
  • Place of Presentation: 東京・オリンピック記念青少年総合センター
  • Year and Date: 2010-07-14
• [Presentation] C. elegans has a memory for NaCl concentrations (2010)
  • Author(s): 大野速雄
  • Organizer: 4th East Asia C. elegans Meeting
  • Place of Presentation: 東京・オリンピック記念青少年総合センター
  • Year and Date: 2010-07-13
• [Presentation] Neural and behavioral mechanisms of response to an odorant depending on its concentration (2010)
  • Author(s): 吉田和史
  • Organizer: 4th East AsiaC. elegans Meeting
  • Place of Presentation: 東京・オリンピック記念青少年総合センター
  • Year and Date: 2010-07-13
• [Presentation] Synaptic regulation of DAG and phosphoinositides by M01F1. 7, the conserved phosphatidylinositol transfer protein (2010)
  • Author(s): 岩田遼
  • Organizer: 4th East Asia C. elegans Meeting
  • Place of Presentation: 東京・オリンピック記念青少年総合センター
  • Year and Date: 2010-07-12
• [Presentation] Ascaroside phromones regulate olfactory plasticity through the SNET-1 peptide., Neuronal Development, Synaptic Function & Behavior C (2010)
  • Author(s): 飯野雄一
  • Organizer: Neuronal Development, Synaptic Function & Behavior C. elegans Topic Meeting 2010
  • Place of Presentation: マディソン, U. S. A
  • Year and Date: 2010-06-29
• [Presentation] Neural and behavioral mechanisms of response to an odorant depending on its concentration. (2010)
  • Author(s): 吉田和史
  • Organizer: Neuronal Development, Synaptic Function & Behavior C. elegans Topic Meeting 2010
  • Place of Presentation: マディソン, U. S. A
  • Year and Date: 2010-06-29
• [Presentation] Dynamics of neural circuitunderlying salt chemotaxis learning in C. elegans. (2010)
  • Author(s): 小田茂和
  • Organizer: Neuronal Development, Synaptic Function & Behavior C. elegans Topic Meeting 2010
  • Place of Presentation: マディソン, U. S. A
  • Year and Date: 2010-06-29
• [Presentation] The role of INS-1, an insulin-like peptide, in salt chemotaxis learning. (2010)
  • Author(s): 富岡征大
  • Organizer: Neuronal Development, Synaptic Function & Behavior C. elegans Topic Meeting 2010
  • Place of Presentation: マディソン, U. S. A
  • Year and Date: 2010-06-29
• [Presentation] 線虫C. elegansの味覚神経ASERによる塩走性学習の制御とその分子メカニズム (2009)
  • Author(s): 安達健, 他
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-13
• [Presentation] 線虫C. elegansの塩走性学習におけるインスリン様ペプチドINS-1の分泌の役割 (2009)
  • Author(s): 富岡征大他
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-11
• [Presentation] C.エレガンスの塩走性行動の制御機構の解明 (2009)
  • Author(s): 國友博文他
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-11
• [Presentation] Strength of salt chemotaxis learning intensity and retention of sensory signaling of memor y i n Caenorhabditiselegans (2009)
  • Author(s): 小野寺馨他
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] Dopamine-depende ntsecretion of INS-1, an insulin-likepeptide, regulates salt chemotaxislearning in C. elegans (2009)
  • Author(s): 富岡征大他
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Remarks]
  • URL: http://molecular-ethology.biochem.s.u-tokyo.ac.jp/IINO_lab_J.html