2011 Fiscal Year Final Research Report
Analyses of the left-right asymmetric development in Drosophila
| Project/Area Number |
21370099
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
MATSUNO Kenji 東京理科大学, 基礎工学部, 教授 (60318227)
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| Co-Investigator(Renkei-kenkyūsha) |
MAEDA Reo 東京理科大学, 基礎工学部, 助教 (40453831)
OKUMURA Takashi 東京理科大学, 基礎工学部, 研究員 (20449234)
NAKAYAMA Minoro 東京理科大学, 総合研究機構, ポストドクトラル研究員 (40449236)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 器官形成 / 左右非対称性 / 左右軸 |
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| Research Abstract |
Our group is interested in the left-right(LR) asymmetric development in Drosophila. To address this issue, we focused on the directional LR asymmetry of the Drosophila embryonic gut. We found that the activation of Wnt signaling and Rho GTPase pathway are required for the LR asymmetric development of the embryonic gut. We developed a computer modeling that recuperates the RL asymmetric development and obtained imaging data to improve our model.
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[Journal Article] Canonical Wnt signaling in the visceral muscle is required for left-right asymmetric development of the Drosophila midgut2012
Author(s)
Kuroda, J., Nakamura, M., Yoshida, M., Yamamoto, H., Maeda, T., Taniguchi, K., Nakazawa, N., Hatori, R., Ishio, A., Ozaki, A., Shimaoka, S., Ito, T., Iida, H., Okumura, T., Maeda, R., and Matsuno, K
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Journal Title
Mech. Dev
Volume: 128
Pages: 625-629
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[Journal Article] Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila2012
Author(s)
Yamakawa, T., Yamada, K., Sasamura, T., Nakazawa, N., Kanai, M., Suzuki, E., Fortini, M. E., and Matsuno, K
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Journal Title
Development
Volume: 139
Pages: 558-567
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[Journal Article] Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis2011
Author(s)
Taniguchi, K., Maeda, R., Ando, T., Okumura, T., Nakazawa, N., Hatori, R., Nakamura, M., Hozumi, S., Fujiwara, H., Matsuno, K
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Journal Title
Science
Volume: 333
Pages: 339-341
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[Journal Article] Drosophila carrying Pex3 or Pex16 mutations are models of zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes2011
Author(s)
Nakayama, M., Sato, H., Okuda, T., Fujisawa, N., Kono, N., Arai, H., Suzuki, E., Umeda, M., Ishikawa, H. O., and Matsuno, K
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Journal Title
PLoS ONE
Volume: 6(8)
Pages: e22984
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[Journal Article] Roles of Drosophila Deltex in Notch receptor endocytic trafficking and activation2011
Author(s)
Yamada, K., Fuwa, T. J., Ayukawa, T., Tanaka, T., Nakamura, A., Wilkin, M. B., Baron, M., and Matsuno, K
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Journal Title
Genes to Cells
Volume: 16
Pages: 261-272
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[Journal Article] Introgression of Drosophila simulans Nup160(nuclear pore protein 160) in Drosophila melanogaster Alone Does Not Cause Inviability but Does Cause Female Sterility2010
Author(s)
Sawamura, K., Maeharam, K., Mashino, S., Kagesawa, T., Kajiwara, M., Matsuno, K., Takahashi, A., Takano-shimizu, T
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Journal Title
Genetics
Volume: 186
Pages: 669-678
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[Journal Article] Two pathways for importing GDP-fucose into the ER lumen function redundantly in the O-fucosylation of Notch in Drosophila2010
Author(s)
Ishikawa, H. O., Ayukawa, T., Nakayama, N., Higashi, S., Kamiyama, S., Nishihara, S., Aoki, K., Ishida, N., Sanai, Y., and Matsuno, K
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Journal Title
J. Biol. Chem
Volume: 285
Pages: 4122-4129
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[Journal Article] Left-right asymmetric morphogenesis of the anterior midgut depends on the activation of a non-muscle myosin II in Drosophila2010
Author(s)
Okumura, T., Fujiwara, H., Taniguchi, K., Kuroda, J., Nakazawa, N., Nakamura, M., Hatori, R., Ishio, A., Maeda, R., and Matsuno, K
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Journal Title
Dev. Biol
Volume: 344
Pages: 693-706
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