2011 Fiscal Year Final Research Report
Development of techniques for diagnosis and prevention of fish disease by the analysis of T cell function in fish immune response
| Project/Area Number |
21380126
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General fisheries
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SOMAMOTO Tomonori 九州大学, 農学研究科, 准教授 (40403993)
ARAKI Kyousuke 鹿児島大学, 水産学部, 助教 (30409073)
NAKAYASU Tihaya 水産総合研究センター, 養殖研究所, 研究員 (00311225)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 魚類 / T細胞 / 細胞性免疫 / ギンブナ / CD4 / CD8 / IFNγ |
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| Research Abstract |
In this project, we showed a) tissue distribution of T cell subset, and the characteristics of CD4^+helper T cells using monoclonal antibodies in ginbuna, b) killing mechanisms and differentiation and activation of CD8^+ cytotoxic T lymphocyte, c) primary importance of cell-mediated immunity in the defense against cell-associate bacteria, d) establishment of basic tools for the induction of Th1 response in fish, e) identification of immune genes and analysis of immune mechanisms in rainbow trout, flounder and yellowtail which enable the studies on cell-mediated immunity in important fishes in aquaculture.
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Research Products
(55 results)
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[Journal Article] Dijkstra A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes2010
Author(s)
Ohashi K., F. Takizawa, N. Tokumaru, C. Nakayasu, H. Toda, U. Fischer, T. Moritomo1, K. Hashimoto, T. Nakanishi, J. M.
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Journal Title
Immunogenetics
Volume: 62(8)
Pages: 543-59
Peer Reviewed
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