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2011 Fiscal Year Final Research Report

Development of early diagnosis for obesity and diabetes using insulin signaling gene expressions in dogs and cats

Research Project

  • PDF
Project/Area Number 21380195
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical veterinary science
Research InstitutionNippon Veterinary and Life Science University

Principal Investigator

ARAI Toshiro  日本獣医生命科学大学, 獣医学部, 教授 (70184257)

Co-Investigator(Kenkyū-buntansha) ISHIOKA Katsumi  日本獣医生命科学大学, 獣医学部, 准教授 (60409258)
YAMAMOTO Ichiro  日本獣医生命科学大学, 獣医学部, 講師 (00424763)
HASHIMOTO Haruo  実験動物中央研究所, 研究部, 研究員 (30353478)
Project Period (FY) 2009 – 2011
Keywords動物 / 肥満 / 糖尿病 / 遺伝子 / インスリン / 早期診断
Research Abstract

Early diagnostic method for obesity and diabetes mellitus using insulin signaling gene was investigated in dogs and cats. Expression of insulin signaling genes, insulin receptor substrate(IRS)-1,-2 and phosphatidylinositol kinase(PI3K), decreased significantly at the early stage of obesity in dogs and cats. Changes in plasma cholesterol profiles and adiponectin concentrations and peripheral leukocytes adiponectin receptor(ADIPOR) gene expression were also significant in obese and diabetic animals. IRS-2, PI3K and ADIPOR mRNA expression and plasma cholesterol profiles and adiponectin concentrations appeared to be potential diagnostic markers for obesity and diabetes in dogs and cats.

  • Research Products

    (29 results)

All 2012 2011 2010 2009 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (10 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Non-targeted analyses of animal plasma : betaine and choline represent the nutritional and metabolic status2012

    • Author(s)
      Katayama K, Sato T, Arai T, Amao H, Ohta Y, Ozawa T, Kenyon PR, Tazaki H
    • Journal Title

      Journal of Animal Physiology and Animal Nutrition

    • DOI

      DOI:10.1111/j.1439-0396.2011.01250.x

    • Peer Reviewed
  • [Journal Article] cDNA cloning and mRNA expression of canine pancreatic and duodenum homeobox 1(Pdx-1)2012

    • Author(s)
      Takemitsu H, Yamamoto I, Lee P, Ohta T, Mori N, Arai T
    • Journal Title

      Research in Veterinary Science

    • DOI

      DOI:10.1016/j.rvsc.2011.11.003

    • Peer Reviewed
  • [Journal Article] Comparison of the plasma insulin and adiponectin concentrations as metabolic markers in clinically healthy dogs with ageing2012

    • Author(s)
      Mori N, Kawasumi K, Arai T
    • Journal Title

      Journal of Animal and Veterinary Advances

      Volume: 11(7) Pages: 971-974

    • DOI

      DOI:10.3923/java.2012.971.974

    • Peer Reviewed
  • [Journal Article] Elevated plasma adiponectin level and peripheral blood leukocyte adiponectin receptor expression in dogs suffering from insulin deficiency2012

    • Author(s)
      Mori N, Lee P, Yamamoto I, Arai T
    • Journal Title

      The Open Veterinary Science Journal

      Volume: 6 Pages: 1-7

    • DOI

      DOI:10.2174/1874318801206010001

    • Peer Reviewed
  • [Journal Article] Establishmentof temporary criteria for metabolic syndrome(MS) diagnosis and assessment of the occurrence rate of MS in cats2012

    • Author(s)
      Mori N, Kawasumi K, Suzuki T, Yamamoto I, Kobayashi M, Arai T
    • Journal Title

      Journal of Animal and Veterinary Advances

      Volume: 11(5) Pages: 615-617

    • DOI

      DOI:10.3923/java.2012.615.61

    • Peer Reviewed
  • [Journal Article] Lipogenic gene expression in abdominal adipose and liver tissues of diet-induced overweight cats2011

    • Author(s)
      Lee P, Mori A, Takemitsu H, Yamamoto I, Arai T
    • Journal Title

      The Veterinary Journal

      Volume: 190 Pages: 150-153

    • DOI

      DOI:10.1016/j.tvjl.2011.04.003

    • Peer Reviewed
  • [Journal Article] Study on establishment of congenic strains and screening of characteristics in IRS-2 deficient mice to support translational research on type 2 diabetes2011

    • Author(s)
      Haruo Hashimoto
    • Journal Title

      Experimental Animal

      Volume: 60(1) Pages: 21-32

    • URL

      https://www.jstage.jst.go.jp/article/expanim/60/1/60_1_1/_pdf

    • Peer Reviewed
  • [Journal Article] 高脂肪食給与により肥満なせた犬の白血球中のインスリン感受性に関連する遺伝子発現量の変化2011

    • Author(s)
      酒井美帆、森伸子、山本一郎、川角浩、新井敏郎
    • Journal Title

      予防動物医学

      Volume: 3巻1号 Pages: 11-19

    • URL

      https://www.jspvm.com

    • Peer Reviewed
  • [Journal Article] Two chicken neuromedin U receptors : Characterization of primary structure, biological activity and tissue distribution2011

    • Author(s)
      Yamamoto I, Nakao N, Kaiya H, Miyazato M, Tsushima N, Arai T, Tanaka M
    • Journal Title

      General and Comparative Endocrinology

      Volume: 174 Pages: 116-123

    • DOI

      DOI:10.1016/j.ygcen.2011.08.004

    • Peer Reviewed
  • [Journal Article] Evaluation of serum and urine 1, 5-anhydro-D-glucitol and myo-inositol concentrations in healthy dogs2011

    • Author(s)
      Miki Y, Mori A, Hayakawa N, Niki T, Oda H, Saeki K, Sato T, Tazaki H, Ishioka K, Arai T, Sako T
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 73 Pages: 1117-1126

    • URL

      https://www.jstage.jst.go.jp/article/jvms/73/9/73_10_0372/_pdf

    • Peer Reviewed
  • [Journal Article] Insulin treatment-induced daily changes to plasma adiponectin and TNF-α level and lipid metabolism parameters in dogs suffering from type 1 diabetes mellitus2011

    • Author(s)
      Mori N, Lee P, Yamamoto I, Nozawa S, Arai T
    • Journal Title

      Asian Journal of Animal and Veterinary Advances

      Volume: 6 Pages: 844-850

    • DOI

      DOI:10.3923/ajava.2011.844.850

    • Peer Reviewed
  • [Journal Article] Evaluation of artificial pancreas technology for continuous blood glucose monitoring in dogs2011

    • Author(s)
      Mori A, Lee P, Yokoyama T, Oda H, Saeki K, Miki Y, Nozawa S, Azakami D, MomotaY, Makino Y, Matsubara T, Osaka M, Ishioka K, Arai T, Sako T
    • Journal Title

      Journal of Artificial Organs

      Volume: 14 Pages: 133-139

    • DOI

      DOI:10.1007/s10047-011-0560-1

    • Peer Reviewed
  • [Journal Article] Alteration of physical indexes and plasma biochemical markers in overweight dogs induced by high-fat diet feeding2011

    • Author(s)
      Mori N, Sakai M, Yamamoto I, Arai T
    • Journal Title

      Research Journal of Veterinary Sciences

      Volume: 4 Pages: 14-19

    • DOI

      DOI:10.3923/rjvs.2011.14.19

    • Peer Reviewed
  • [Journal Article] Time-action profiles of insulin detemir in normal and diabetic dogs2011

    • Author(s)
      Sako T, Mori A, Lee P, Oda H, Saeki K, Miki Y, Kurishima M, Miura K, Nozawa S, Mizutani H, Makino Y, Ishioka K, Arai T
    • Journal Title

      Research in Veterinary Science

      Volume: 90 Pages: 396-403

    • DOI

      DOI:10.1016/j.rvsc.2010.07.001

    • Peer Reviewed
  • [Journal Article] Obesity induced changes to plasma adiponectin concentration and cholesterol lipoprotein composition profile in cats2011

    • Author(s)
      Muranaka S, Mori N, Hatano Y, Saito TR, Lee P, Kojima M, Kigure M, Yagishita M, Arai T
    • Journal Title

      Research in Veterinary Science

      Volume: 91 Pages: 358-361

    • DOI

      DOI:10.1016/j.rvsc.2010.09.012

    • Peer Reviewed
  • [Journal Article] Potential use of cholesterol lipoprotein profile to confirm obesity status in dogs2011

    • Author(s)
      Mori N, Lee P, Kondo K, Kido T, Saito T, Arai T
    • Journal Title

      Veterinary Research Communications

      Volume: 35 Pages: 223-235

    • DOI

      DOI:10.1007/s11259-011.9466-x

    • Peer Reviewed
  • [Presentation] 椎間板ヘルニアを発症した犬血液中の代謝成分について2011

    • Author(s)
      佐藤稲子、片山欣哉、田村勝利、多川政弘、新井敏郎、田崎弘之
    • Organizer
      第152回日本獣医学会学術集会
    • Year and Date
      20110900
  • [Presentation] 犬猫のメタボリックシンドローム判定基準と世田谷地区での取り組み2011

    • Author(s)
      新井敏郎
    • Organizer
      日本獣医内科学アカデミー/日本獣医臨床病理学会2011年大会
    • Place of Presentation
      横浜
    • Year and Date
      20110300
  • [Presentation] 貴堂としみ、肥満した犬猫の血漿リポ蛋白質コレステロールの変化2010

    • Author(s)
      森伸子、波多野豊、酒井美帆、村中志朗、新井敏郎、近藤和雄
    • Organizer
      第150回日本獣医学会学術集会
    • Place of Presentation
      帯広
    • Year and Date
      20100900
  • [Presentation] Clinical siginificance of insulin and adiponectin in obese animals2010

    • Author(s)
      Arai T
    • Organizer
      XIVth Congress of the International Society for Animal Clinical Pathology(招待講演)
    • Place of Presentation
      Corvallis, USA
    • Year and Date
      20100700
  • [Presentation] Multifaced analysis of lipidmetabolism in canines2010

    • Author(s)
      Mori N, Lee P, Kondo T, Kodi T, Arai T
    • Organizer
      XIVth Congress of the International Society for Animal Clinical Pathology
    • Place of Presentation
      Corvallis, USA
    • Year and Date
      20100700
  • [Presentation] Changes in peripheral lymphocyte subsets in pituitary dependent hyperadrenocortism dogs2010

    • Author(s)
      Mori A, Lee P, Sako T, Arai T
    • Organizer
      XIVth Congress of the International Society for Animal Clinical Pathology
    • Place of Presentation
      Corvallis, USA
    • Year and Date
      20100700
  • [Presentation] cDNA cloning and mRNA expression of cat GPR392010

    • Author(s)
      Yamamoto I, Hayashi T, Takemitsu H, Mori N, Arai T
    • Organizer
      XIVth Congress of the International Society for Animal Clinical Pathology
    • Place of Presentation
      Corvallis, USA
    • Year and Date
      20100700
  • [Presentation] cDNA cloning and mRNA expression of dog PDX12010

    • Author(s)
      Takemitsu H, Yamamoto I, Mori N, Arai T
    • Organizer
      XIVth Congress of the International Society for Animal Clinical Pathology
    • Place of Presentation
      Corvallis USA
    • Year and Date
      20100700
  • [Presentation] 犬および猫の肥満・糖尿病・メタボリックシンドロームの遺伝子診断2009

    • Author(s)
      新井敏郎
    • Organizer
      第30回動物臨床医学会(招待講演)
    • Place of Presentation
      大阪
    • Year and Date
      20091100
  • [Presentation] 犬の高トリグリセリド血症の新しい診断基準2009

    • Author(s)
      森伸子、山本一郎、新井敏郎
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      鳥取
    • Year and Date
      20090900
  • [Book] 犬と猫の早期疾病診断学2011

    • Author(s)
      新井敏郎、山本一郎, 他
    • Total Pages
      206
    • Publisher
      チクサン出版
  • [Book] TYPE 1 DIABETES Complications, Pathogenesis, and Alternative Treatments

    • Author(s)
      Arai T, 他
    • Total Pages
      470
    • Publisher
      INTECH
  • [Remarks]

    • URL

      http://www.nvlu.ac.jp/research/005.html/

URL: 

Published: 2013-07-31  

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