2011 Fiscal Year Final Research Report
Design and delivery of plasmid vector for spatiotemporal control of the expression of therapeutic protein and siRNA
| Project/Area Number |
21390009
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIKAWA Makiya 京都大学, 大学院・薬学研究科, 准教授 (40273437)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ドラッグデリバリー / 遺伝子治療 / RNA干渉 / プラスミドDNA |
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| Research Abstract |
Interferon-γ(IFN-γ) was selected as a therapeutic protein and several IFN-γgene therapy systems were developed. Selection of proper promoters of IFN-γ-expressing vectors resulted in the regulation of the time profile of IFN-γtransgene expression. A fusion of IFN-γwith a protein that regulates the tissue distribution resulted in the spatiotemporal control of IFN-γafter in vivo gene transfer. This control led to an increase in the therapeutic effect of IFN-γ-based gene therapy on metastatic tumor with reduction in adverse effects.
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Research Products
(21 results)
