2011 Fiscal Year Final Research Report
Analysis of molecular mechanisms underlying lymphocyte homing using high endothelial venule-specific conditional knockout mice
| Project/Area Number |
21390023
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Yasuyuki 静岡県立大学, 薬学部, 教授 (80160034)
MURAI Toshiyuki 大阪大学, 医学系研究科, 助教 (20311756)
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| Project Period (FY) |
2009 – 2011
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| Keywords | リンパ球ホーミング / ヘパラン硫酸 / ケモカイン / 高内皮細静脈 |
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| Research Abstract |
Circulating lymphocytes migrate into the parenchyma of lymph nodes through specialized blood vessels called high endothelial venules(HEVs). In this process, chemokines are important for the activation of lymphocyte integrins and the subsequent firm attachment of lymphocytes to HEVs. By generating novel HEV-specific conditional knockout mice, we demonstrate in this study that heparan sulfate sequesters chemokines on the surface of HEVs and presents them to lymphocytes to facilitate this migratory process.
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[Journal Article] Endothelial Heparan Sulfate Controls Chemokine Presentation in Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes2010
Author(s)
Bao X, Moseman EA, Saito H, Petryanik B, Thiriot A, Hatakeyama S, Ito Y, Kawashima H, Yamaguchi Y, Lowe JB, von Andrian UH and Fukuda M.
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Journal Title
Immunity
Volume: 33
Pages: 817-829
DOI
Peer Reviewed
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[Journal Article] Identification of mRNA splicing factors as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells2009
Author(s)
Hatakeyama S, Sugihara K, Nakayama J, Akama TO, Wong SM, Kawashima H, Zhang J, Smith DF, Ohyama C, Fukuda M, and Fukuda MN.
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Journal Title
Proc. Natl. Acad. Sci
Volume: 106
Pages: 3095-3100
DOI
Peer Reviewed
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[Presentation] Novel Anti-Carbohydrate Antibodies Reveal the Cooperative Function of Sulfated N-and O-Glycans in Lymphocyte Homing2011
Author(s)
Hirakawa J, Tsuboi K, Sato K, Kobayashi M, Watanabe S, Takakura A, Imai Y, Ito Y, Fukuda M, and Kawashima H.
Organizer
Keystone Symposia-New Frontiers at the Interface of Immunity and Glycobiology
Place of Presentation
Lake Louise, Alberta, Canada
Year and Date
2011-03-08
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