2012 Fiscal Year Final Research Report
Studies on novel mechanisms of environmental chemicals-induced toxicity using arachidonate-metabolizing enzyme genetically modified mice
| Project/Area Number |
21390036
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKATANI Yoshihito 昭和大学, 薬学部, 准教授 (80266163)
KUWATA Hiroshi 昭和大学, 薬学部, 講師 (80286864)
YODA Emiko 昭和大学, 薬学部, 助教 (60527183)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 環境化学物質 / プロスタグランジン / ホスホリパーゼA_2 / アラキドン酸代謝 / 遺伝子改変マウス |
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| Research Abstract |
In order to clarify novel mechanisms of environmental chemicals-induced toxicity, we focused on arachidonate metabolism as a target of toxic chemicals and investigated phenotypes of arachidonate-metabolizing enzyme genetically modified mice. As the results, we demonstrated that several arachidonate-metabolizing enzymes are involved in chemicals-induced male reproductive toxicity, neurotoxicity, onset of hydronephrosis and carcinogenesis, and indicated that other enzymes could be targets of chemicals-induced toxicity.
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[Journal Article] Lymphoid tissue phospholipase A_2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators2013
Author(s)
Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH, Murakami M
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Journal Title
J. Exp. Med
Volume: (印刷中)
Peer Reviewed
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[Journal Article] Mast cell maturation is driven via a novel group III phospholipase A_2-prostaglandin D_2-DP1 receptor paracrine axis2013
Author(s)
Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, Kabashima K, Gelb MH, Arita M, Yokomizo T, Nakamura M, Watanabe K, Hirai H, Nakamura M, Okayama Y
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Journal Title
Nat. Immunol
Volume: 14(6)
Pages: 554-563
DOI
Peer Reviewed
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[Journal Article] Physiological roles of group X-secreted phospholipase A_2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function2011
Author(s)
Sato H, Isogai Y, Masuda S, Taketomi Y, Miki Y, Kamei D, Hara S, Kobayashi T, Ishikawa Y, Ishii T, Ikeda K, Taguchi R, Ishimoto Y, Suzuki N, Yokota Y, Hanasaki K, Suzuki-Yamamoto T, Yamamoto K, Murakami M
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Journal Title
J. Biol. Chem
Volume: 286(13)
Pages: 11632-11648
DOI
Peer Reviewed
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[Journal Article] Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca2+-independent phospholipase A_2(C)-deficient mice2010
Author(s)
Yoda E, Hachisu K, Taketomi Y, Yoshida K, Nakamura M, Ikeda K, Taguchi R, Nakatani Y, Kuwata H, Murakami M, Kudo I, Hara S
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Journal Title
J. Lipid Res
Volume: 51(10)
Pages: 3003-3015
DOI
Peer Reviewed
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[Journal Article] Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice2010
Author(s)
Sato H, Taketomi Y, Isogai Y, Miki Y, Yamamoto K, Masuda S, Hosono T, Arata S, Ishikawa Y, Ishii T, Kobayashi T, Nakanishi H, Ikeda K, Taguchi R, Hara S, Kudo I, Murakami M
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Journal Title
J. Clin. Invest
Volume: 120(5)
Pages: 1400-1414
DOI
Peer Reviewed
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[Journal Article] Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice2010
Author(s)
Escoffier J, Jemel I, Tanemoto A, Taketomi Y, Payre C, Coatrieux C, Sato H, Yamamoto K, Masuda S, Pernet-Gallay K, Pierre V, Hara S, Murakami M, De Waard M, Lambeau G, Arnoult C
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Journal Title
J. Clin. Invest
Volume: 120(5)
Pages: 1415-1428
DOI
Peer Reviewed
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[Journal Article] Microsomal prostaglandin E synthase-1 in both cancer cells and host contributes to tumour growth, invasion and metastasis2010
Author(s)
Kamei D, Murakami M, Sasaki Y, Nakatani Y, Majima M, Ishikawa Y, Ishii T, Uematsu S, Akira S, Hara S, Kudo I
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Journal Title
Biochem. J
Volume: 425(2)
Pages: 361-371
DOI
Peer Reviewed
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