2011 Fiscal Year Final Research Report
Discovery and development of antitumor drugs focused on the molecular clock of dedifferentiation and apoptosis during carcinogenesis
| Project/Area Number |
21390047
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
OHDO Shigehiro 九州大学, 大学院・薬学研究院, 教授 (00223884)
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| Co-Investigator(Kenkyū-buntansha) |
KOYANAGI Satoru 九州大学, 大学院・薬学研究院, 准教授 (60330932)
NAOYA Matsunaga 九州大学, 大学院・薬学研究院, 助教 (10432915)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 体内時計 / がん / 分化 / アポトーシス / 創薬 |
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| Research Abstract |
Circadian clock systems have been related in cell cycle and carcinogenesis. Theexpression of molecular clock genes is altered in cancer patients. However, the influenceof an alteration of molecular clock works during carcinogenesis has not been investigatedyet. In this study, the hepatocarcinogenesis by diethylnitrosoamine(DEN) in mice wasinhibited by the down-regulation of cellular dedifferentiation related genes expression. These findings suggest that the control of cellular dedifferentiation related genesexpression is important in carcinogenesis.
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