2012 Fiscal Year Final Research Report
Crosstalk between nuclear receptor and transcription cofactor on brain development and its modulation by environmental chemicals.
| Project/Area Number |
21390065
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHITA Akira (財)冲中記念成人病研究所, 研究員 (20322646)
TAKATSURU Yusuke 群馬大学, 大学院・医学系研究科, 助教 (30446265)
IWASAKI Toshiharu 群馬大学, 大学院・医学系研究科, 講師 (80375576)
SIMOKAWA Noriaki 群馬大学, 大学院・医学系研究科, 准教授 (90235680)
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| Project Period (FY) |
2009 – 2012
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| Keywords | ホルモン / 核内受容体 / 転写因子 / 脳発達 / 環境化学物質 |
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| Research Abstract |
Above-referenced theme was analyzed using thyroid hormone (TH) . TH receptor (TR) system as a model system. Congenital hypothyroid rat showedhyperactivity under novel environment. We found that the effect is induced by disruption of dopamine transport due to a decreased tubulin expression, which is regulated by TH.In primary cerebellar culture, TH induced an increase in dendrite and neurite elongation,which was inhibited by environmental chemicals such as polybrominated diphenylether(PBDE). PBDE did not alter TR-cofactor binding. Instead, it dissociated TR from DNA.
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Author(s)
六反田奈和,堀口淳,岩崎俊晴,鯉淵幸生,高他大輔, 長岡りん,小田原宏樹,時庭秀彰,戸塚勝理,竹吉泉,鯉淵典之
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Journal Title
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Pages: 7-10
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Author(s)
Shimokawa N, Haglund K, Holter SM, Grabbe C, Kirkin V, Koibuchi N, Schulz C, Rozman J, Hoeller D, Qiu CH, Londono MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I,Brech A,Schmidt MH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I
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Peer Reviewed
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Author(s)
Odawara H, Iwasaki T, Horiguchi J, Rokutanda N, Hirooka K, Miyazaki W, Koibuchi Y, Shimokawa N, Iino Y,Takeyoishi I, Koibuchi N
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Journal Title
J Biol Chem
Volume: 284
Pages: 17711-17719
Peer Reviewed
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