2011 Fiscal Year Final Research Report
Molecular basis study on PACAP gene as a risk factor for schizophrenia
| Project/Area Number |
21390069
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
BABA Akemichi 大阪大学, 大学院・薬学研究科, 名誉教授 (70107100)
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| Co-Investigator(Kenkyū-buntansha) |
SHINTANI Norihito 大阪大学, 大学院・薬学研究科, 准教授 (10335367)
HAYATA Atsuko 大阪大学, 連合小児発達学研究科, 助教 (70390812)
HASHIMOTO Hitoshi 大阪大学, 大学院・薬学研究科, 教授 (30240849)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 精神疾患・障害 / 統合失調症 / 神経ペプチドPACAP / 遺伝子改変マウス / 環境因子 / 疾患モデル / セロトニン / スパイン |
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| Research Abstract |
Clinical studies suggest that environmental factors, besides genetic factors, play a key role in etiology of many psychiatric disorders. This study demonstrated that schizophrenia-related behaviors in mice lacking PACAP are highly infuluenced by the environmental factors during the early stages of development. In this mutant, we also found abnormalities in the 5-HT2A receptor function and the hippocampal neuron maturation, suggesting possible involvement of these dysfunctions in the development of schizophrenia-related behaviors in mice lacking PACAP.
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[Journal Article] Baba A PACAP centrally mediates emotional stress-induced corticosterone responses in mice2011
Author(s)
Tsukiyama N, Saida Y, Kakuda M, Shintani N, Hayata A, Morita Y, Tanida M, Tajiri M, Hazama K, Ogata K, Hashimoto H
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Journal Title
Stress
Volume: 14(4)
Pages: 368-375
Peer Reviewed
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[Journal Article] Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal neurogenesis2011
Author(s)
Ago Y, Yoneyama M, Ishihama T, Kataoka S, Kawada K, Tanaka T, Ogita K, Shintani N, Hashimoto H, Baba A, Takuma K, Matsuda T
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Journal Title
Neuroscience
Volume: 172
Pages: 554-561
Peer Reviewed
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[Journal Article] Possible association between the pituitary adenylate cyclase-activating polypeptide(PACAP) gene and major depressive disorder2010
Author(s)
Hashimoto R, Hashimoto H, Shintani N, Ohi K, Hori H, Saitoh O, Kosuga A, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Baba A, Takeda M, Kunugi H.
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Journal Title
Neurosci Lett
Volume: 14 ; 468(3)
Pages: 300-302
Peer Reviewed
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[Journal Article] Depression-like behavior in the forced swimming test in PACAP-deficient mice : amelioration by the atypical antipsychotic risperidone2009
Author(s)
Hashimoto H, Hashimoto R, Shintani N, Tanaka K, Yamamoto A, Hatanaka M, Guo X, Morita Y, Tanida M, Nagai K, Takeda M, Baba A.
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Journal Title
J Neurochem
Volume: 110(2)
Pages: 595-602
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