2011 Fiscal Year Final Research Report
Role of stress response for differentiation and maturation of hematop oietic cells
| Project/Area Number |
21390074
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MOTOHASHI Hozumi 東北大学, 大学院・医学系研究科, 准教授 (00282351)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 転写因子 / 巨核球 / 血小板 / 細胞分化 |
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| Research Abstract |
This study aimed at clarifying how metabolic and oxidative stresses influence the proliferation and differentiation of hematopoietic cells from the viewpoint of CNC-Maf transcription factors. I found that NF-E2 p45 antagonize with Nrf2 and promotes the terminal differentiation of megakaryocytes resulting in the increase of intracellular reactive oxygen species. I also found that NF-E2 p45 directly activates the genes encoding the factors involved in the platelet function. In tumor-bearing mice, expression of NF-E2 p45 and its target genes was robustly increased
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[Journal Article] Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma2012
Author(s)
Inoue D, Suzuki T, Mitsuishi Y, Miki Y, Suzuki S, Sugawara S, Watanabe M, Sakudara A, Endo C, Uruno A, Sasano H, Nakagawa T, Satoh K, Tanaka N, Kubo H, Motohashi H*, and Yamamoto M*.
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Journal Title
Cancer Sci
Volume: 103
Pages: 760-766
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[Journal Article] The critical role of nitric oxide signalling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response2010
Author(s)
Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahtesham AK, Ishima Y, Motohashi H, Yamamoto M and Akaike T.
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Journal Title
J Biol Chem
Volume: 285
Pages: 23970-23984
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[Journal Article] The selective autophagy substrate p62 activates the stress response transcription factor Nrf2 through inactivation of Keap12010
Author(s)
Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou Y.-S., Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S.-i., Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K and Yamamoto M.
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Journal Title
Nat Cell Biol
Volume: 12
Pages: 213-223
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