2012 Fiscal Year Final Research Report
Elucidation of functions and molecular mechanisms ofimmune-related transcription regulatory factors in life sciences
| Project/Area Number |
21390102
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2012
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| Keywords | 自己免疫疾患 / 転写制御因子 / ZFAT / Tespa1 / バセドウ病 |
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| Research Abstract |
We have elucidated that ZFAT is indispensable for mouse embryonic development and a critical transcription factor for primitive hematopoiesis in the regulation of Tal1 in blood islands through the analysis of Zfat-deficient mice. In addition, using T-cell specific conditional Zfat-deficient mice we have reported that ZFAT is crucial for peripheral T cell homeostasis and its T cell receptor-mediated responses. Furthermore, we have demonstrated that Tespa1 is a MAM-associated molecule and critically involved in Ca2+ signaling in T cells, and also identified several independent risk loci for Graves’ disease within the MHC region in the Japanese population.
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