Telomere dysfunction and chromosomal instability in uninvolved tissue with carcinoma by original FISH

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390109
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: TAKUBO Kaiyo 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (00154956)
• Co-Investigator(Renkei-kenkyūsha): AIDA Junko 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (80425678)
• Project Period (FY): 2009 – 2011
• Keywords: テロメア / FISH / 染色体不安定性 / ヒト癌

Research Abstract

1.We demonstrated telomere dysfunction in the uninvolved epithelium with esophageal squamous cell carcinoma and telomere shortening occurred due to excessive alcohol consumption. 2.We first demonstrated excessive telomere shortening of the epidermis in Werner's syndrome patients. 3.We reported the annual reduction-rate of telomere in the human pituitary gland.

Research Products

• [Journal Article] Short telomeres in an oral precancerous lesion : Q-FISH analysis of leukoplakia. (2012)
  • Author(s): Aida J, Kobayashi T, Saku T, Yamaguchi M, Shimomura N, Nakamura K, Ishikawa N, Maruyama S, Chen J, Poon SSS, Sawabe M, Arai T, Takubo K
  • Journal Title: J Oral Pathol Med Volume: 41 Pages: 372-378
  • DOI: DOI:10.1111/j.1600-0714.2011.01120.x
  • Peer Reviewed
• [Journal Article] Hepatocellular Telomere Length in Biliary Atresia Measured by Q-FISH (2012)
  • Author(s): Sanada Y, Aida J, Kawano Y, Nakamura KI, Shimomura N, Ishikawa N, Arai T, Poon SS, Yamada N, Okada N, Wakiya T, Hayashida M, Saito T, Egami S, Hishikawa S, Ihara Y, Urahashi T, Mizuta K, Yasuda Y, Kawarasaki H, Takubo K.
  • Journal Title: World J Surg Volume: 36 Pages: 908-916
  • DOI: DOI:10.1007/s00268-012-1453-z
  • Peer Reviewed
• [Journal Article] Telomere dynamics in the human pituitary gland : robust preservation throughout adult life to centenarian age (2011)
  • Author(s): Ishikawa N, Nakamura K, Izumiyama N, Aida J, Sawabe M, Arai T, Kishimoto H, Fujiwara M, Ishii A, Takubo K.
  • Journal Title: AGE
  • DOI: DOI:10.1007/s11357-011-9280-y
  • Peer Reviewed
• [Journal Article] Palisade vessels as a new histologic marker of esophageal origin in ER Specimens from columnar-lined esophagus (2011)
  • Author(s): Aida J, Vieth M, Ell C, May A, Pech O, Hoshihara Y, Kumagai Y, Kawada K, Hishima T, Tateishi Y, Sawabe M, Arai T, Matsuura M, Takubo K
  • Journal Title: Am J Surg Pathol Volume: 36 Pages: 1140-1145
  • DOI: DOI:10.1097/PAS.0b013e3182206c0e
  • Peer Reviewed
• [Journal Article] Accelerated in vivo epidermal telomere loss in Werner syndrome (2011)
  • Author(s): Ishikawa N, Nakamura K, Izumiyama-Shimomura N, Aida J, Ishii A, Goto M, Ishikawa Y, Asaka R, Matsuura M, Hatamochi A, Kuroiwa M, Takubo K
  • Journal Title: Aging Volume: 3 Pages: 417-429
  • Peer Reviewed
• [Journal Article] Clinicopathologic characteristics of basaloid squamous carcinoma of the esophagus (2011)
  • Author(s): Arai T, Aida J, Nakamura K, Ushio Y, Takubo K
  • Journal Title: Esophagus Volume: 8 Pages: 169-177
  • DOI: DOI:10.1007/s10388-011-0280-x
  • Peer Reviewed
• [Journal Article] Alcoholics show reduced telomere length in the oesophagus (2011)
  • Author(s): Aida J, Yokoyama A, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SSS, Fujiwara M, Sawabe M, Matsuura M, Arai T, Takubo K
  • Journal Title: J Pathol Volume: 223 Pages: 410-416
  • DOI: DOI:10.1002/path.2817
  • URL: http://www.thejournalofpathology.com
  • Peer Reviewed
• [Journal Article] Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence (2010)
  • Author(s): Takubo K, Aida J, Izumiyama N, Ishikawa N, Fujiwara M. Poon SSS, Kondo H, Kammori M, Matsuura M, Sawabe M, Arai T, Baird DM, Nakamura K
  • Journal Title: Mech Age Dev Volume: 131 Pages: 614-624
  • DOI: DOI:10.1016/j.mad.2010.08.007
  • Peer Reviewed
• [Journal Article] Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ (2010)
  • Author(s): Takubo K, Fujita M, Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Grabsch H, Arai T, Aida J
  • Journal Title: J Pathol Volume: 221 Pages: 201-209
  • DOI: DOI:10.1002/path.2704
  • URL: http://www.thejournalofpathology.com
  • Peer Reviewed
• [Journal Article] Changesof telomere length with aging (2010)
  • Author(s): Takubo K, Aida J, Izumiyama-Shimomura N, Ishikawa N, Sawabe M, Kurabayashi R, Shiraishi H, Arai T, Nakamura K
  • Journal Title: Geriatr Gerontol Int Volume: 10(s1) Pages: 197-206
  • DOI: DOI:10.1111/j.1447-0594.2010.00605.x
  • Peer Reviewed
• [Presentation] テロメア短縮とヒトの老化、癌化 (2011)
  • Author(s): 田久保海誉、相田順子
  • Organizer: 100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20110428-30
• [Presentation] アルコール症患者の食道上皮のテロメアが短縮している (2011)
  • Author(s): 相田順子、田久保海誉
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20110428-30
• [Presentation] Q-FISH法による膀胱癌の悪性度とテロメア長 (2011)
  • Author(s): 仲村賢一、田久保海誉
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20110428-30
• [Presentation] 低リポプロテイン(a)血症では担癌率が高い:高齢者専門病院の連続病理解剖例での検討 (2011)
  • Author(s): 沢辺元司、田久保海誉
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20110428-30
• [Presentation] Q-FISH法と免疫蛍光抗体法を用いた細胞種類別テロメア長の測定法の開発と膵島細胞種別テロメア長解析 (2011)
  • Author(s): 泉山七生貴、田久保海誉
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20110428-30
• [Presentation] 正角化型口腔異型上皮における構成細胞のテロメア長と染色体不安定性についてQ-FISH法による解析 (2010)
  • Author(s): 相田順子、田久保海誉
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 20100427-29
• [Presentation] Q-FISH法による培養線維芽細胞を用いたテロメア短縮と染色体異常 (2010)
  • Author(s): 仲村賢一、田久保海誉
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 20100427-29
• [Presentation] 胆道閉鎖症の肝組織におけるテロメア長の解析 (2010)
  • Author(s): 眞田幸弘、田久保海誉
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 20100427-29
• [Remarks]
  • URL: http://www.ttaggg-rtgp.org/