Translational TGF-β Research for Diagnosis, Treatment, and Prevention of Cancer

2012 Fiscal Year Final Research Report

• Project/Area Number: 21390115
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: University of Tsukuba
• Principal Investigator: KATO Mitsuyasu 筑波大学, 医学医療系, 教授 (20194855)
• Project Period (FY): 2009 – 2012
• Keywords: がん / TGF-β / TMEPAI / THG-1 / MafK / Gpnmb

Research Abstract

Transforming growth factor-β-related molecules TMEPAI, TSC22D4 (THG-1), and MafK were elucidated to initiate carcinogenic activities and promote malignant progression. Study on the molecular mechanisms how these oncogenes functioning provided the novel target molecules for cancer treatment and prevention. We established monoclonal antibodies for TMEPAI, TSC22D4, MafK, Gpnmb and so on. These antibodies will open the application of these works for clinicopathological research and cancer diagnosis.

Research Products

• [Journal Article] Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice. (2012)
  • Author(s): Oishi H, Itoh S, Matsumoto K, Ishitobi H, Suzuki R, Ema M, Kojima T, Uchida K, Kato M, Miyata T and Takahashi S.
  • Journal Title: J. Biochem. Volume: 152 Pages: 549-555
  • Peer Reviewed
• [Journal Article] Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions. (2012)
  • Author(s): Itoh F, Itoh S, Adachi T, Ichikawa K, Matsumura Y, Takagi T, Festing M, Watanabe T, Weinstein M, Karlsson S and Kato M
  • Journal Title: Blood. Volume: 119 Pages: 5320-5328
  • Peer Reviewed
• [Journal Article] Interference of E2-2-mediated effect inendothelial cells by FAM96B through its limited expression of E2-2. (2011)
  • Author(s): Yang W, Itoh F, Ohya H, Kishimoto F, Tanaka A, Nakano N, Itoh S, Kato M
  • Journal Title: Cancer Sci Volume: 102 Pages: 1808-1814
  • Peer Reviewed
• [Journal Article] Requirement of TCF7L2 for TGF-β-dependent transcriptional activation of the TMEPAI gene. (2010)
  • Author(s): Nakano N, Itoh S, Watanabe Y, Maeyama K, Itoh F, and Kato M.
  • Journal Title: J Biol Chem. Volume: 285 Pages: 38023-38033
  • Peer Reviewed
• [Journal Article] TMEPAI, a transmembrane TGF-β-inducible protein,sequesters Smad proteins from active participation in TGF-β signaling (2010)
  • Author(s): Watanabe Y, Itoh S, GotoT, OhnishiE, InamitsuM, ItohF, SatohK, WiercinskaE, Yan gW, ShiL, TanakaA, NakanoN, MommaasAM, ShibuyaH, ten DijkeP and KatoM.
  • Journal Title: Mol Cell. Volume: 37 Pages: 123-134
  • Peer Reviewed
• [Journal Article] TGF-β Signaling in Gingival Fibroblast-Epithelial Interaction. (2010)
  • Author(s): Ohshima M, Yamaguchi Y, Matsumoto N, Micke P, Takenouchi Y, Nishida T, Kato M, Komiyama K, Abiko Y, Ito K, Otsuka K and Kappert K.
  • Journal Title: J Dent Res. Volume: 89 Pages: 1315-1321
  • Peer Reviewed
• [Journal Article] Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis. (2010)
  • Author(s): Tanaka A, ItohF, TakezawaT, Itoh S and Kato M
  • Journal Title: Blood Volume: 115 Pages: 4138-4147
  • Peer Reviewed
• [Journal Article] Poor Vessel Formation in Embryos from Knock-in Mice Expressing ALK5 with L45 Loop Mutation Defective in Smad Activation (2009)
  • Author(s): Itoh F, Itoh S, Carvalho RLC, Adachi T, Ema M, Goumans MJ, Larsson J, Karlsson S, Takahasi S, Mummery CL, ten Dijke P and Kato M
  • Journal Title: Lab Invest. Volume: 89 Pages: 800-810
  • Peer Reviewed
• [Presentation] Roles of THG-1/Tsc22D4 in cell proliferation (2013)
  • Author(s): Hiroyuki Suzuki
  • Organizer: differentiation and tumorigenesis
  • Place of Presentation: Hyatt Regency Maui, Hawaii, USA
  • Year and Date: 2013-02-25
• [Presentation] MafK mediates tumorigenic potential and EMT in breast cancer cells (2013)
  • Author(s): Yukari Okita
  • Organizer: AACR-JCA Joint Conference
  • Place of Presentation: Hyatt Regency Maui, Hawaii, USA
  • Year and Date: 2013-02-23
• [Presentation] Tumorigenic function of TMEPAI in lung cancer cells (2012)
  • Author(s): Vo Nguyen Thao Thanh
  • Organizer: LICR TGF-β meeting
  • Place of Presentation: Leiden University Medical Center, Leiden, The Netherlands
  • Year and Date: 2012-08-30
• [Presentation] 細胞増殖、分化、癌化におけるTsc-22ファミリー分子の役割 (2012)
  • Author(s): 鈴木裕之
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 京王プラザホテル, 東京.
  • Year and Date: 2012-04-28
• [Presentation] 乳腺細胞の上皮間葉転換と腫瘍形成におけるMafKの役割 (2012)
  • Author(s): 沖田結花里
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 京王プラザホテル, 東京.
  • Year and Date: 2012-04-27
• [Presentation] TMEPAI in Cancer Cell Biology (2012)
  • Author(s): Mitsuyasu Kato
  • Organizer: The1^<st>International Symposium by JSPS Core-to-Core Program "Cooperative International Framework in TGF-β Family Signaling"
  • Place of Presentation: University of Tokyo, Tokyo
  • Year and Date: 2012-01-23
• [Presentation] TGF-beta stimulated clone-22 domain family 4 (TSC22D4) is a novel oncogene activated in squamous cell carcinoma (2010)
  • Author(s): Mitsuyasu Kato
  • Organizer: TGF-β meeting
  • Place of Presentation: Leiden University of Medical Center, Leiden, The Netherlands
  • Year and Date: 2010-09-03
• [Presentation] Smad traps for negative regulation of TGF-β signaling (2010)
  • Author(s): Mitsuyasu Kato
  • Organizer: The 59th Fujihara International Seminar
  • Place of Presentation: Grand Hotel New Oji, Tomakomai
  • Year and Date: 2010-07-15
• [Presentation] 新規TGF-β関連分子のがんにおける機能 (2010)
  • Author(s): 加藤光保
  • Organizer: 革新的医薬シーズ 開発研究シンポジウム
  • Place of Presentation: 筑波大学先端学際領域研究(TARA)センター, つくば
  • Year and Date: 2010-06-22
• [Presentation] TGF-β related genes in early carcinogenesis (2009)
  • Author(s): Mitsuyasu Kato
  • Organizer: International Symposium on TGF-β signaling, Inflammation, and Cancer Prevention
  • Place of Presentation: Gachon University of Medicine and Science, Incheon, Korea.
  • Year and Date: 2009-11-20
• [Remarks] ホームページ
  • URL: http://www.md.tsukuba.ac.jp/epatho/index.html
• [Patent(Industrial Property Rights)] 画像処理システム、画像処理方法及び画像処理プログラム (2012)
  • Inventor(s): 加藤光保、他
  • Industrial Property Rights Holder: 加藤光保、他
  • Industrial Property Number: 特願2012-140594
  • Filing Date: 2012-06-22