メモリーTh1/Th2細胞の形成と機能維持のエビジェネティック制御に関する研究

2011 Fiscal Year Annual Research Report

• Project/Area Number: 21390147
• Research Institution: Chiba University
• Principal Investigator: 中山 俊憲 千葉大学, 大学院・医学研究院, 教授 (50237468)
• Keywords: アレルギー・喘息 / 細胞・組織 / シグナル伝達 / 免疫学 / タンパク質

Research Abstract

免疫記憶細胞の形成、特に「エフェクターTh1/Th2細胞が機能を維持した状態で、生体内でメモリーTh1/Th2細胞に分化し長期間維持される分子機構」を解明することを目的として下記の研究を行った。
1.ポリコームやトライソラックス群遺伝子産物によるGATA3遺伝子発現制御機構の解明
平成22年度から行っている、ES細胞、B細胞、ナイーブT細胞、エフェクターTh2細胞の各段階における、MeninとポリコームのBmi1複合体の結合遺伝子の網羅的同定に関する実験をChIP-sequence法を用いて解析した。ポリコームやトライソラックス分子による遺伝子発現調節に関して数多くの知見を得た。現在論文を作成中である。平成21年から行っているGATA3のChIP-sequence解析は、成果をまとめて論文発表をした。
GATA3複合体の新規会合分子ChD4がプロテオーム解析で同定され、その分子をレトロウイルスやレンチウイルスでT細胞に強制発現させ、Th1/Th2分化、メモリーTh1Th2細胞のin vivoでの形成と機能解析を行い、新規分子の機能を細胞レベルで解析した。ノックアウトマウスを作成中である。
今年度は連携研究者としてこの部分を免疫発生学・助教・細川裕之先生が担当した.
2.ポリコームやトライソラックス群遺伝子産物によるメモリーTh1/Th2細胞の形成機構の解明
ポリコーム複合体のEZH2がTh2分化を抑制的に制御していることが分かったので、その分子メカニズムを解析した。
3.生体レベルでの解析、ポリコームとトライソラックスによるアレルギー反応・病態形成の制御
平成23年度は、生体レベルでの解析にも力を入れた。メモリーTh1/Th2細胞の形成や機能維持に関して大きな役割を持つことが分かった分子に関して、生体レベルでの解析を行った。特に、我々が樹立したメモリーTh1細胞、Th2細胞依存的なマウス喘息気道炎症モデルを利用し、アレルギー反応・病態形成における分子制御機構を生体レベルで解析した。遺伝子操作マウスとしては、Men1-KOマウス、EZH2conditional KOマウス、ApoA-II-KOマウスなどを用いた。

Research Products

• [Journal Article] Murine Schnurri-2 controls Natural Killer cell function and lymphoma development (2012)
  • Author(s): Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., Tanaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S., Nakayama, T.
  • Journal Title: Leuk.Lymphoma Volume: 53 Pages: 479-489
  • DOI: 10.3109/10428194.2011.625099
  • Peer Reviewed
• [Journal Article] Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3 (2011)
  • Author(s): Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, J. D., Tokoyoda, K. Hosokawa, H., Yamashita, M. Nakayama, T
  • Journal Title: Immunity Volume: 35 Pages: 733-745
  • DOI: DOI:10.1016/j.immuni.2011.08.017
  • Peer Reviewed
• [Journal Article] IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation (2011)
  • Author(s): Takahashi, K., Hirose, K., Kawashima, S., Niwa, Y., Wakashin, H., Iwata, A., Tokoyoda, K., Renauland Nakad, J.-C., Iwamoto, I., Nakayama, T. Nakajima, H
  • Journal Title: J. Allergy Ciln. Immunol Volume: 128 Pages: 1067-1076
  • DOI: DOI:10.1016/j.jaci.2011.06.018
  • Peer Reviewed
• [Journal Article] Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin (2011)
  • Author(s): Yamauchi, K., Kasuya, Y., Kuroda, F., Tanaka, K., Tsuyusaki, J., Ishizaki, S., Matsunaga, H., Iwamura, C., Nakayama, T. Tatsumi, K
  • Journal Title: Respir. Res Volume: 12 Pages: 131
  • DOI: DOI:10.1186/1465-9921-12-131
  • Peer Reviewed
• [Journal Article] NKT-cell-based immunotherapies in clinical trials (2011)
  • Author(s): Exley, M. A., N Nakayama, T
  • Journal Title: Clin. Immunol Volume: 140 Pages: 117-118
  • DOI: DOI:10.1016/j.clim.2011.04.015
  • Peer Reviewed
• [Journal Article] Anti-tumor immune responses induced by iNKT cell-based immunotherapy for lung cancer and head and neck cancer (2011)
  • Author(s): Motohashi, S., Okamoto, Y., Yoshino, I. Nakayama, T
  • Journal Title: Ciln. Immunol Volume: 140 Pages: 1647-176
  • DOI: DOI:10.1016/j.clim.2011.01.009
  • Peer Reviewed
• [Journal Article] Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function (2011)
  • Author(s): Yamashita, J., Iwamura, C., Sasaki, T., Mitsumori, K., Ohshima, K., Hada, K., Hara, N., Takahashi, M., Kaneshiro, Y., Tanaka, H., Kaneko, K. Nakayama, T
  • Journal Title: J. Immunol Volume: 186 Pages: 3410-3420
  • DOI: DOI:10.4049/jimmunol.1002924
  • Peer Reviewed
• [Journal Article] Migration and immunological reaction after the administration of α GalCer-pulsed antigen-presenting cells into the submucosa of patients with head and neck cancer (2011)
  • Author(s): Kurosaki, M., Horiguchi, S., Yamasaki, K., Uchida, Y., Motohashi, S., Nakayama, T., Sugimoto, A., Okamoto, Y.
  • Journal Title: Cancer Immunol.Immunother Volume: 60 Pages: 207-215
  • DOI: 10.1007/s00262-0010-0932-z
  • Peer Reviewed
• [Journal Article] Activation of pulmonary invariant NKT cells leads to exacerbation of acute lung injury caused by LPS through local production of IFN-g and TNF-a by Gr-1^+ monocytes (2011)
  • Author(s): Aoyagi, T., Yamamoto, N., Hatta, M., Tanno, D., Miyazato, A., Ishii, K., Suzuki, K., Nakayama, T., Taniguchi, M., Kunishima, H., Hirakata, Y., Kaku, M., Kawakami, K.
  • Journal Title: Int.Immunol. Volume: 23 Pages: 97-108
  • DOI: 10.1098/intimm/dxq460
  • Peer Reviewed
• [Journal Article] Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy (2011)
  • Author(s): Yamasaki, K., Horiguchi, S., Kurosaki, M., Kunii, N., Nagato, K., Hanaoka, H., Shimizu, N., Ueno, N., Yamamoto, S., Taniguchi, M., Motohashi, S., Nakayama, T., Okamoto, Y.
  • Journal Title: Clin.Immunol. Volume: 138 Pages: 255-265
  • DOI: 10.1016/j.clim.2010.11.014
  • Peer Reviewed
• [Journal Article] Increase of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in 2-year sublingual immunotherapy (SLIT) for Japanese cedar pollinosis (2011)
  • Author(s): Fujimura, T., Yonekura, S., Horiguchi, S., Taniguchi, Y., Saito, A., Yasueda, H., Inamine, A., Nakayama, T. Takemori, T., Taniguchi, M., Sakaguchi, M., Okamoto, Y.
  • Journal Title: Clin.Immunol. Volume: 139 Pages: 65-74
  • DOI: 10.1016/j.clim.2010.12.022
  • Peer Reviewed
• [Journal Article] Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses (2011)
  • Author(s): Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Kitajima, M., Shinoda, K., Namiki, T., Terasawa, K., Nakayama, T.
  • Journal Title: Clin.Immunol. Volume: 139 Pages: 267-276
  • DOI: 10.1016/j.clim.2010.12.022
  • Peer Reviewed
• [Journal Article] TSLP enhances the function of helper type2 cells (2011)
  • Author(s): Kitajima, M., Lee, H.-C., Nakayama, T., Ziegler, S.F.
  • Journal Title: Eur.J.Immunol. Volume: 41 Pages: 1862-1870
  • DOI: 10.1002/eji.201041195
  • Peer Reviewed
• [Journal Article] Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3.186:6378-6389(2011) (2011)
  • Author(s): Horiuchi, S., Onodera, A., Hosokawa, H., Watanabe, Y., Tanaka, T., Sugano, S., Suzuki, Y., Nakayama, T.
  • Journal Title: J.Immunol. Volume: 186 Pages: 6378-6389
  • DOI: 10.4049/jimmunol.1100179
  • Peer Reviewed
• [Journal Article] HIV-1 Nef impairs multiple T-cell functions in antigen-specific immune response in mice (2011)
  • Author(s): Fujii, H., Ato, M., Takahashi, Y., Otake, K., Hashimoto, S., Kaji, T., Tsunetsugu-Yokota, Y., Fujita, M., Adachi, A., Nakayama, T., Taniguchi, M. Koyasu, S., Takemori, T.
  • Journal Title: Int.Immunol. Volume: 23 Pages: 433-441
  • DOI: 10.1093/intimm/dxr031
  • Peer Reviewed
• [Journal Article] Memory type 2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells (2011)
  • Author(s): Kitajima, M., Ito, T., Tumes, J.D., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Ziegler, F. S., Nakayama, T.
  • Journal Title: Cancer Res Volume: 71 Pages: 4790-4798
  • DOI: 10.1158/0008-5472.CAN-10-1572
  • Peer Reviewed
• [Journal Article] Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice (2011)
  • Author(s): Tsuyusaki, J., Kuroda, F., Kasuya, Y., Ishizaki, I., Yamauchi, K., Sugimoto, H., Kono, T., Iwamura, C., Nakayama, T., Tatsumi, K.
  • Journal Title: J.Recept.Sig.Transduct.Res. Volume: 31 Pages: 434-439
  • DOI: 10.3109/10799893.2011.631929
  • Peer Reviewed
• [Journal Article] The apelin/APJ system induces maturation of the tumor vasculature and improves the efficiency of immune therapy
  • Author(s): Kidoya, H., Kunii, N., Naito, H., Muramatsu, T., Okamoto, Y., Nakayama, T., Takakura, N.
  • Journal Title: Oncogen Volume: (in press)
  • Peer Reviewed
• [Journal Article] Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance
  • Author(s): Satoh, M., Andoh, Y., Clingan, S.C., Ogura, H., Fujii, S., Nakayama, T., Taniguchi, M., Hirata, N., Ishimori, N., Tsutsui, H., Onoe, K., Iwabuchi, K.
  • Journal Title: PLoS ONE Volume: (in press)
  • Peer Reviewed
• [Presentation] Real-time cellular imaging of T lymphocyte accumulation in a mouse asthmamodel.喘息肺での浸潤リンパ球のリアルタイムイメージング 第85回日本細菌学会総会 (2012)
  • Author(s): Hasegawa, A., Shirai, M., Nakayama, T.
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2012-03-28
• [Presentation] The functional analysis of Exocyst complex subunit Sec8 on antigen presenting cells (2011)
  • Author(s): Matsunaga, S., Takahashi, K., Taguchi, J., Sakuramoto, M., Nakayama, T., Hashimoto, K.
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-15
• [Presentation] TGFβ converts an IL-4 function into a Th1 cell inducer (2011)
  • Author(s): Yamashita, M., Kuwahara, M., Suzuki, J., Nakayama, T., Tofukuji, S.
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-14
• [Presentation] VILI (Ventilator-Induced Lung Injury) modelにおけるNKT細胞の関与と役割/Protective role of NKT cells against ventilator-induced lung injury (2011)
  • Author(s): 志賀由佳、菅又龍一、長尾朋和、岩村千秋、川上和義、河内正治、中山俊憲、鈴木和男
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-29
• [Presentation] 肺炎球菌の血流感染及び肺炎における、IL-13による宿主防御の役割/Protective role of IL-13 in sepsis and respiratory infection against S.pneumoniae (2011)
  • Author(s): Yamamoto, N., DelaCruz, C., Takahashi, M., Fujita, T., Hosokawa, H., Nakayama, T., Akahori, Y., Yamamoto, H., Kawakami, K., Askenase, W.P., Kanemitsu, K.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-29
• [Presentation] 好酸球性慢性鼻副鼻腔炎に伴う鼻茸の病理学的形成機序の解明/Pathological mechanism of eosinophilic chronic rhinosinusitis with nasal polyps (2011)
  • Author(s): Iinuma, T., Inamine, A., Sakurai, T., Sakurai, D., Yamamoto, H., Nakayama, T., Okamoto, Y.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-29
• [Presentation] マウスSchnurri-2はNK細胞の機能とリンパ腫の発症を制御する/Murine Schnurri-2 controls Natural Killer cell function and lymphoma development (2011)
  • Author(s): Yamashita, J., Iwamura, C., Hosokawa, H., Sasaki, T., Tumes, D., Motohashi, S., Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] 進行期および再発非小細胞肺癌に対するa-GalCerパルス抗原提示細胞の局所投与療法-第I相試験-/A phase I study of loco-regional immunotherapy by trans-bronchial injection of a-Galactosylceramide-pulsed antigen presenting cells in patients with advanced and recurrent non-small cell lung cancer (2011)
  • Author(s): Ishibashi, F., Motohashi, S., Taniguchi, M., Yoshino, I., Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] 頭頸部癌患者に対するα GalCerパルス樹状細胞の投与部位と移動部位に関する検討/Migration and immunological reaction after administration of alpha-GalCer pulsed antigen presenting cells into submucosa of patients with head and neck cancer (2011)
  • Author(s): 佐々原剛、山崎一樹、本橋新一郎、岡本美孝、中山俊憲
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] メモリーTh2細胞はNK細胞を活性化し抗腫瘍効果を持続させる/Memory type2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells (2011)
  • Author(s): Ito, T., Kitajima, M., Tumes, J. D., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] 活性化NKT細胞によるメモリーTh2細胞の増加と機能変化/Selective expansion and functional modulation of memory Th2 cells by activated NKT cells in vivo (2011)
  • Author(s): 岩村千秋、篠田健太、高橋克己、中山俊憲
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] 腸炎の発症におけるCD69分子の役割/Crucial role for CD69 in the pathogenesis of DSS-induced colitis (2011)
  • Author(s): Hasegawa, A., Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] 骨髄におけるTヘルパー記憶の成立/Establishment of T helper memory in bone marrow (2011)
  • Author(s): Tokoyoda, K., Shinoda, K., Hanazawa, A., Hayashizaki, K., Radbruch, A., Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] α-GalCerパルスDCの口腔粘膜投与におけるアレルギー性鼻炎炎症の抑制機序の解明/Oral Submucosal administration of a-GalCer pulsed DCs inhibits local inflammation of allergic rhinitis (2011)
  • Author(s): Sakurai, T., Inamine, A., Sakurai, D., Iinuma, T., Ishii, Y., Nakayama, T., Okamoto, Y.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] TGFβはIL-4をTh1細胞分化誘導因子へと変換する/TGFβ converts IL-4 into a Th1 cell inducer (2011)
  • Author(s): Tofukuji, S., Kuwahara, M., Suzuki, J., Ohara, O., Nakayama, T., Yamashita, M.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] GATA3 ChIP-sequence解析を用いたTh2特異的遺伝子の転写調節機構の解明/Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3 (2011)
  • Author(s): 堀内周、小野寺淳、細川裕之、渡邊友紀子、中山俊憲
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] STAT6によって誘導されるポリコームとトライソラックスの置換反応/STAT6-mediated displacement of Polycomb by Trithorax complex establishes long-term maintenance of GATA3 expression in Th2 cells (2011)
  • Author(s): Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Horiuchi, S., Watanabe, Y., Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] Sox4はTGFβにより誘導され、Th2型免疫反応を抑制する/Sox4 acts as a downstream target of TGFβ and suppresses Th2 type immune responses (2011)
  • Author(s): Kuwahara, M., Iwamura, C, Shinoda, K., Tofukuji, S., Suzuki, J., Nakayama, T., Yamashita, M.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] Discovery of SH-2251 as a novel site-specific inhibitor for chromatin remodeling at the Il-5 gene locus (2011)
  • Author(s): Suzuki, J., Tofukuji, S., Kuwahara, M., Imamura, M., Nakayama, T., Ohara, O., Kato, F., Yamashita, M.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] Type II NKT 細胞は食事誘導性肥満を調節する/Type II NKT cells operatediet-induced obesity by mediating adipose tissue inflammation and steatohepatitis (2011)
  • Author(s): Satoh, M., Eshima, K., Nakayama, T., Taniguchi, M., Ishimori, N., Iwabuchi, K.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] 多発性筋炎マウスモデルにおける肥満細胞の役割の解析/Crucial roles of mast cells in a murine model of polymyositis (2011)
  • Author(s): 横田雅也、鈴木浩太郎、中込大樹、岩田有史、常世田好司、中山俊憲、上阪等、中島裕史
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] ROGはTh2による肥満細胞の脱顆粒を制御する事で接触性皮膚炎を抑制する/Repressor of GATA negatively regulates the induction of contact hypersensitivity via Th2-induced mast cell degranulation (2011)
  • Author(s): Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Shinoda, K., Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] α-GalCer-Ag DC の口腔粘膜下投与におけるアレルギー性鼻炎炎症の抑制機序の解明 (2011)
  • Author(s): 櫻井利興、稲嶺絢子、櫻井大樹、飯沼智久、米倉修二、石井保之、中山俊憲、岡本美孝
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-12
• [Presentation] アレルギー性鼻炎に対する免疫療法、最新の知見と展望 第61回日本アレルギー学会秋季学術大会 (2011)
  • Author(s): 櫻井大樹、米倉修二、山本陛三朗、稲嶺絢子、中山俊憲、岡本美孝
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-12
• [Presentation] IL-22は気道上皮細胞によるIL-25産生を抑制し、アレルギー性気道炎症を制御する (2011)
  • Author(s): 高橋健太郎、廣瀬晃一、川島沙紀、丹羽祐輔、若新英史、岩田有史、小林芳久、常世田好司、中山俊憲、谷口正実、秋山一男
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] 好酸球性副鼻腔炎鼻茸に浸潤するリンパ球の機能解析 (2011)
  • Author(s): 飯沼智久、稲嶺絢子、山本陛三朗、櫻井大樹、米倉修二、櫻井利興、中山俊憲、岡本美孝
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3 (2011)
  • Author(s): Onodera, A., Horiuchi, S., Hosokawa, H., Watanabe, Y., Suzuki, Y., Nakayama, T.
  • Organizer: NCI Symposium on Chromosome Structure and Function
  • Place of Presentation: Bethesda, MD, USA
  • Year and Date: 2011-11-01
• [Presentation] NKT cell-based Immunotherapy for non-small cell lung cancer (2011)
  • Author(s): Motohashi, S., Ishibashi, F., Taniguchi, M., Yoshino, I., Nakayama, T.
  • Organizer: 6th International Symposium on CD1 and NKT Cells
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-09-27
• [Presentation] NKT cell-mediated regulation of antigen-specific memory Th2 cell function (2011)
  • Author(s): Nakayama, T. Iwamura, C
  • Organizer: 6th International Symposium on CD1 and NKT Cells
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-09-25
• [Presentation] NKT細胞免疫系をターゲットにしたがんの免疫細胞治療 (2011)
  • Author(s): 中山俊憲、本橋新一郎
  • Organizer: 第15回日本がん免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-06-30
• [Presentation] Trans-bronchial intratumoral injection of α GalCer-pulsed APCs in patients with advanced or recurrent lung cancer (2011)
  • Author(s): Ishibashi, F., Motohashi, S., Taniguchi, M., Yoshino, I., Nakayama, T.
  • Organizer: 第15回日本がん免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-06-30
• [Presentation] Epigenetic regulation of GATA3 expression and its target genes in Th2 cells (2011)
  • Author(s): Nakayama, T.
  • Organizer: 45^<th> Joint Working Conference on Immunology and Viral Diseases
  • Place of Presentation: CA, USA
  • Year and Date: 2011-06-20
• [Presentation] Regulation of memory Th2 cell function and allergic airway inflammation via polycomb and trithorax molecules (2011)
  • Author(s): Nakayama, T., Onodera, A.
  • Organizer: 30^<th> Congress of the European Academy of Allergy and Clinical Immunology
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2011-06-15
• [Presentation] TGFβはIL-4をTh1細胞分化誘導因子へと変換する (2011)
  • Author(s): 東福寺聡一、桑原誠、鈴木淳平、中山俊憲、山下政克
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] HMG box型転写因子Sox4はTGF-β刺激で誘導され、Th2細胞分化を抑制する (2011)
  • Author(s): 桑原誠、岩村千秋、篠田健太、東福寺聡一、鈴木淳平、中山俊憲、山下政克
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] Eomesodermin controls IL-5 production in memory Th2 cells through the inhibition of GATA3 activity (2011)
  • Author(s): 遠藤裕介、小野寺淳、細川裕之、中山俊憲
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] Selective expansion and functional modulation of memory Th2 cells by activated NKT cells in vivo (2011)
  • Author(s): 岩村千秋、篠田健太、花澤麻美、中山俊憲
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] Epigenetic control of memory Th2 cell function via Polycomb and Trithorax molecules (2011)
  • Author(s): Nakayama, T., Onodera, A
  • Organizer: EUThyme-Rolduc Meeting
  • Place of Presentation: Leeuwenhorst, NL
  • Year and Date: 2011-05-24
• [Presentation] GATA3 ChIP-sequence解析を用いたTh2特異的遺伝子の転写調節機構の解明 (2011)
  • Author(s): 堀内周, 小野寺淳, 細川裕之, 渡邊友紀子, 鈴木穣, 中山俊憲
  • Organizer: 第5回日本エピジェネティックス研究会
  • Place of Presentation: 熊本
  • Year and Date: 2011-05-19
• [Patent(Industrial Property Rights)] 関節リウマチに対する抗IL-6受容体抗体療法の有効性の予測方法 (2011)
  • Inventor(s): 中島裕史、池田啓、加々美新一郎、鈴木快枝、中山俊憲、岩本逸夫、古田俊介、小原收、野中謙、山下政克、的場亮
  • Industrial Property Rights Holder: 国立大学法人千葉大学、財団法人かずさティー・エヌ・エー研究所
  • Industrial Property Number: 特願:2011-156921
  • Filing Date: 2011-07-15