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2011 Fiscal Year Final Research Report

Memory Th1/Th2 cell differentiation and its epigenetic regulation

Research Project

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Project/Area Number 21390147
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionChiba University

Principal Investigator

NAKAYAMA Toshinori  千葉大学, 大学院・医学研究院, 教授 (50237468)

Project Period (FY) 2009 – 2011
Keywords免疫記憶
Research Abstract

Immunological Memory is a central theme in acquired immunity. The findings from the research on Immunological Memory will contribute to the development of more effective and safer vaccines against infectious diseases, as well as can be beneficial to the development of therapeutic vaccines for controlling so called pathogenic immune memory cells that trigger allergy or autoimmune diseases, and furthermore, to the development of vaccines for cancer. In this study, we found that Polycomb group molecule EZH2 and Trithorax group molecules Men-1 control the generation and functional maintenance of Th2 memory cells.

  • Research Products

    (44 results)

All 2012 2011 2010 2009

All Journal Article (32 results) (of which Peer Reviewed: 32 results) Presentation (10 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance2012

    • Author(s)
      Satoh, M., Andoh, Y., Clingan, S. C., Ogura, H., Fujii, S., Nakayama, T., Taniguchi, M., Hirata, N., Ishimori, N., Tsutsui, H., Onoe, K. Iwabuchi, K
    • Journal Title

      PLoS ONE

      Volume: 7(2)

    • DOI

      DOI:10.1371/journal.pone.0030568

    • Peer Reviewed
  • [Journal Article] MurineSchnurri-2 controls Natural Killer cellfunction and lymphoma development2012

    • Author(s)
      Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., anaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S. Nakayama, T
    • Journal Title

      Leuk.Lymphoma

      Volume: 53(3) Pages: 479-86

    • DOI

      DOI:10.3109/10428194.2011.625099

    • Peer Reviewed
  • [Journal Article] The apelin/APJ system induces maturation of the tumor vasculature and improves the efficiency of immune therapy2011

    • Author(s)
      Kidoya, H., Kunii, N., Naito, H., Muramatsu, T., Okamoto, Y., Nakayama, T. Takakura, N
    • Journal Title

      Oncogene in press

    • DOI

      DOI:10.38/onc.2011.489

    • Peer Reviewed
  • [Journal Article] Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice2011

    • Author(s)
      Tsuyusaki, J., Kuroda, F., Kasuya, Y., Ishizaki, I., Yamauchi, K., Sugimoto, H., Kono, T., Iwamura, C., Nakayama, T. Tatsumi, K
    • Journal Title

      J. Recept. Sig. Transduct. Res

      Volume: 31 Pages: 434-439

    • DOI

      DOI:10.3109/10799893.2. 011.631929

    • Peer Reviewed
  • [Journal Article] Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA32011

    • Author(s)
      Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, J. D., Tokoyoda, K. Hosokawa, H., Yamashita, M. Nakayama, T
    • Journal Title

      Immunity

      Volume: 35 Pages: 733-745

    • DOI

      DOI:10.1016/j.immuni.2011.08.017

    • Peer Reviewed
  • [Journal Article] IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation2011

    • Author(s)
      Takahashi, K., Hirose, K., Kawashima, S., Niwa, Y., Wakashin, H., Iwata, A., Tokoyoda, K., Renauland Nakad, J.-C., Iwamoto, I., Nakayama, T. Nakajima, H
    • Journal Title

      J. Allergy Ciln. Immunol

      Volume: 128 Pages: 1067-1076

    • DOI

      DOI:10.1016/j.jaci.2011.06.018

    • Peer Reviewed
  • [Journal Article] Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin2011

    • Author(s)
      Yamauchi, K., Kasuya, Y., Kuroda, F., Tanaka, K., Tsuyusaki, J., Ishizaki, S., Matsunaga, H., Iwamura, C., Nakayama, T. Tatsumi, K
    • Journal Title

      Respir. Res

      Volume: 12 Pages: 131

    • DOI

      DOI:10.1186/1465-9921-12-131

    • Peer Reviewed
  • [Journal Article] NKT-cell-based immunotherapies in clinical trials2011

    • Author(s)
      Exley, M. A., N Nakayama, T
    • Journal Title

      Clin. Immunol

      Volume: 140 Pages: 117-118

    • DOI

      DOI:10.1016/j.clim.2011.04.015

    • Peer Reviewed
  • [Journal Article] Anti-tumor immune responses induced by iNKT cell-based immunotherapy for lung cancer and head and neck cancer2011

    • Author(s)
      Motohashi, S., Okamoto, Y., Yoshino, I. Nakayama, T
    • Journal Title

      Ciln. Immunol

      Volume: 140 Pages: 1647-176

    • DOI

      DOI:10.1016/j.clim.2011.01.009

    • Peer Reviewed
  • [Journal Article] Memory type 2 helper T cells induce long-lasting anti-tumor immunityby activating natural killer cells2011

    • Author(s)
      Kitajima, M., Ito, T., Tumes, J. D., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Ziegler, F. S. Nakayama, T
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 4790-4798

    • DOI

      DOI:10.1158/0008-5472.CAN-10-1572

    • Peer Reviewed
  • [Journal Article] TSLP enhances the function of helper type2 cells. Eur2011

    • Author(s)
      Kitajima, M., Lee, H.-C., Nakayama, T. Ziegler, S. F
    • Journal Title

      J. Immunol

      Volume: 41 Pages: 1862-1870

    • DOI

      DOI:10.1002/eji.201041195

    • Peer Reviewed
  • [Journal Article] Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses2011

    • Author(s)
      Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Kitajima, M., Shinoda, K., Namiki, T., Terasawa, K. Nakayama, T
    • Journal Title

      Clin. Immunol

      Volume: 139 Pages: 267-276

    • DOI

      DOI:10.1016/j.clim.2011.02.009

    • Peer Reviewed
  • [Journal Article] Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA32011

    • Author(s)
      Horiuchi, S., Onodera, A., Hosokawa, H., Watanabe, Y., Tanaka, T., Sugano, S., SuzukiY. Nakayama, T
    • Journal Title

      J. Immunol

      Volume: 186 Pages: 6378-6389

    • DOI

      DOI:10.4049/jimmunol.1100179

    • Peer Reviewed
  • [Journal Article] ncrease of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in 2-year sublingual immunotherapy (SLIT) for Japanese cedar pollinosis2011

    • Author(s)
      Fujimura, T., Yonekura, S., Horiguchi, S., Taniguchi, Y., Saito, A., Yasueda, H., Inamine, A., Nakayama, T., Takemori, T., Taniguchi, M., Sakaguchi, M. Okamoto, Y
    • Journal Title

      Clin. Immunol

      Volume: 139 Pages: 65-74

    • DOI

      DOI:10.1016/j.clim.2010.12.022

    • Peer Reviewed
  • [Journal Article] Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy2011

    • Author(s)
      Yamasaki, K., Horiguchi, S., Kurosaki, M., Kunii, N., Nagato, K., Hanaoka, H., Shimizu, N., Ueno, N., Yamamoto, S., Taniguchi, M., Motohashi, S., Nakayama, T. Okamoto, Y
    • Journal Title

      Clin. Immunol

      Volume: 138 Pages: 255-265

    • DOI

      DOI:10.1016/j.clim.2010.11.014 2011

    • Peer Reviewed
  • [Journal Article] Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function2011

    • Author(s)
      Yamashita, J., Iwamura, C., Sasaki, T., Mitsumori, K., Ohshima, K., Hada, K., Hara, N., Takahashi, M., Kaneshiro, Y., Tanaka, H., Kaneko, K. Nakayama, T
    • Journal Title

      J. Immunol

      Volume: 186 Pages: 3410-3420

    • DOI

      DOI:10.4049/jimmunol.1002924

    • Peer Reviewed
  • [Journal Article] Migration and immunological reaction after the administration of αGalCer-pulsed antigen -presenting cells into the submucosa of patients with head and neck cancer2011

    • Author(s)
      Kurosaki, M., Horiguchi, S., Yamasaki, K., Uchida, Y., Motohashi, S., Nakayama, T., Sugimoto, A. Okamoto, Y
    • Journal Title

      Cancer Immunol

      Volume: 60 Pages: 207-215

    • DOI

      DOI:10.1007/s00262-010-0932-z

    • Peer Reviewed
  • [Journal Article] Activation of pulmonary invariant NKT cells leads to exacerbation of acute lung injury caused by LPS through local production of IFN-_γ and TNF-α by Gr-1^+ monocytes2011

    • Author(s)
      Aoyagi, T., Yamamoto, N., Hatta, M., Tanno, D., Miyazato, A., Ishii, K., Suzuki, K., Nakayama, T., Taniguchi, M., Kunishima, H., Hirakata, Y., Kaku, M. Kawakami, K
    • Journal Title

      Int. Immunol

      Volume: 23 Pages: 97-108

    • DOI

      DOI:10.1093/intimm/dxq460 2011

    • Peer Reviewed
  • [Journal Article] Role of NKT cells in allergic asthma. Curr2010

    • Author(s)
      Iwamura, C. Nakayama, T
    • Journal Title

      Opin. Immunol

      Volume: 22 Pages: 807-81

    • DOI

      DOI:10.1016/j.coi.2010.10.008

    • Peer Reviewed
  • [Journal Article] STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells2010

    • Author(s)
      Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Kanai, A., Suzuki, Y. Nakayama, T
    • Journal Title

      J. Exp. Med

      Volume: 207 Pages: 2493-2506

    • DOI

      DOI:10.1084/jem.20100760

    • Peer Reviewed
  • [Journal Article] The TCR-mediated signaling pathways that control the direction of helper T cell differentiation2010

    • Author(s)
      Nakayama, T. Yamashita, M
    • Journal Title

      Semin. Immunol

      Volume: 22 Pages: 303-309

    • DOI

      DOI:10.1016/j.smim.2010.04.010

    • Peer Reviewed
  • [Journal Article] Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species2010

    • Author(s)
      Suzuki, S., Tanaka, T., Poyurovsky, V. M., Nagano, H., Mayama, T., Ohkubo, S., Lokshin, M., Hosokawa, H., Nakayama, T., Suzuki, Y., Sugano, S., Sato, E., Nagao, T., Yokote, K., Tatsuno, I. Prives, C
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 107 Pages: 7461-7466

    • DOI

      DOI:10.1073/pnas.1002459107

    • Peer Reviewed
  • [Journal Article] Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung2010

    • Author(s)
      Suzuki, A., Iwamura, C., Shinoda, K., Tumes, J. D., Kimura, Y. M., Hosokawa, H., Endo, Y., Horiuchi, S., Tokoyoda, K., Koseki, H., Yamashita, M. Nakayama, T
    • Journal Title

      J. Immunol

      Volume: 184 Pages: 4510-4520

    • DOI

      DOI:10.4049/jimmunol.0903426

    • Peer Reviewed
  • [Journal Article] The induced regulatory T-cell level, defined as the proportion of IL10+Foxp3+ cells among CD25+CD4+ leukocytes, is an available therapeutic biomarker for sublingual immunotherapy : A preliminary report2010

    • Author(s)
      Fujimura, T., Yonekura, S., Taniguchi, Y., Horiguchi, S., Saito, A., Yasueda, H., Nakayama, T., Takemori, T., Taniguchi, M., Sakaguchi, M. Okamoto, Y
    • Journal Title

      Int. Arch. Allergy Immunol

      Volume: 153 Pages: 378-387

    • DOI

      DOI:10.1159/000316349

    • Peer Reviewed
  • [Journal Article] lColor-coded real-time cellular imaging of T lymphocyte accumulation and focus formation in mouse asthma model2010

    • Author(s)
      Hasegawa, A., Hayashi, K., Kishimoto, H., Yang, M., Tofukuji, S., Suzuki, K., Nakajima, H., Hoffman, R. M., Shirai, M. Nakayama, T
    • Journal Title

      J Allergy Clin. Immunol

      Volume: 125 Pages: 461-468

    • DOI

      DOI:10.1016/j.jaci.2009.09.016

    • Peer Reviewed
  • [Journal Article] Organization of immunological memory by bone marrow stroma2010

    • Author(s)
      Tokoyoda, K., Hauser A. E., Nakayama, T. Radbruch, A
    • Journal Title

      Nat. Rev. Immunol

      Volume: 10 Pages: 193-200

    • DOI

      DOI:10.1038/nri2727

    • Peer Reviewed
  • [Journal Article] Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells2010

    • Author(s)
      Iwamura, C., Shinoda, K., Yoshimura, M., Watanabe, Y., Obata, A. Nakayama, T
    • Journal Title

      Allergology International

      Volume: 59 Pages: 67-73

    • DOI

      DOI:10.2332/allergolint.09-OA-0118

    • Peer Reviewed
  • [Journal Article] CD69 controls the pathogenesis of allergic airway inflammation2009

    • Author(s)
      Miki, H. T., Hasegawa, A., Iwamura, C., Shinoda, K., Tofukuji, S., Watanabe, Y., Hosokawa, H., Motohashi, S., Hashimoto, K., Shirai, M., Yamashita, M. Nakayama, T
    • Journal Title

      J. Immunol

      Volume: 183 Pages: 8203-8215

    • DOI

      DOI:10.4049/jimmunol.0900646

    • Peer Reviewed
  • [Journal Article] he Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA32009

    • Author(s)
      Kohu, K., Ohmori, H., Wong, W. F., Onda, D., Wakoh, T., Kon, S., Yamashita, M., Nakayama, T., Kubo, M. Satake, M
    • Journal Title

      J. Immunol

      Volume: 183 Pages: 7817-7824

    • DOI

      DOI:10.4049/jimmunol.0802527

    • Peer Reviewed
  • [Journal Article] Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice2009

    • Author(s)
      Kitajima, M., Iwamura, C., Miki, H. T., Shinoda, K., Endo, Y., Watanabe, Y., Shinnakasu, R., Hosokawa, H., Hashimoto, K., Motohashi, S., Koseki, H., Ohara, O., Yamashita, M. Nakayama, T.
    • Journal Title

      J. Immunol

      Volume: 183 Pages: 5388-5396

    • DOI

      DOI:10.4049/jimmunol.0804155

    • Peer Reviewed
  • [Journal Article] Combination therapy of in vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma2009

    • Author(s)
      Kunii, N., Horiguchi, S., Motohashi, S., Yamamoto, H., Ueno, N., Yamamoto, S., Sakurai, D., Taniguchi, M., Nakayama, T. Okamoto, Y
    • Journal Title

      Cancer Sci

      Volume: 100 Pages: 1092-1098

    • DOI

      DOI:10.1111/j.1349-7006.2009.01135

    • Peer Reviewed
  • [Journal Article] Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory2009

    • Author(s)
      Nakayama, T. Yamashita, M
    • Journal Title

      Semin. Immunol

      Volume: 21 Pages: 78-83

    • DOI

      DOI:10.1016/j.smim.2009.02.001

    • Peer Reviewed
  • [Presentation] STAT6 によって誘導されるポリコ.ムとトライソラックスの置換反応/ STAT6 -mediated displacement of Polycomb by Trithorax complex establishes long-term maintenance of GATA3 expression in Th2 cells2011

    • Author(s)
      Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Horiuchi, S., Watanabe, Y. Nakayama, T
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-27
  • [Presentation] Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA32011

    • Author(s)
      Onodera, A., Horiuchi, S., Hosokawa, H., Watanabe, Y., Suzuki, Y. Nakayama, T
    • Organizer
      NCI Symposium on Chromosome Structure and Function
    • Place of Presentation
      Bethesda, MD
    • Year and Date
      2011-11-01
  • [Presentation] NKT cell-mediated regulation of antigen-specific memory Th2 cell function2011

    • Author(s)
      Nakayama, T. Iwamura, C
    • Organizer
      6th International Symposium on CD1 and NKT Cells
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-09-25
  • [Presentation] Epigenetic regulation of GATA3 expression and its target genes in Th2 cells2011

    • Author(s)
      Nakayama, T
    • Organizer
      45th Joint Working Conference on Immunology and Viral Diseases
    • Place of Presentation
      CA, USA
    • Year and Date
      2011-06-20
  • [Presentation] Regulation of memory Th2 cell function and allergic airway inflammation via polycomb and trithorax molecules2011

    • Author(s)
      Nakayama, T. Onodera, A
    • Organizer
      30th Congress of the European Academy of Allergy and Clinical Immunology
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2011-06-15
  • [Presentation] GATA3 ChIP-sequence解析を用いたTh2特異的遺伝子の転写調節機構の解明2011

    • Author(s)
      堀内周, 小野寺淳, 細川裕之, 渡邊友紀子, 鈴木穣, 中山俊憲
    • Organizer
      第5回日本エピジェネティックス研究会
    • Place of Presentation
      熊本
    • Year and Date
      2011-05-19
  • [Presentation] Generation and maintenance of memory Th1/Th2 cell identity2010

    • Author(s)
      Endo, Y., Onodera, A. Nakayama, T
    • Organizer
      2010 ASBMB
    • Place of Presentation
      Tahoe City, USA
    • Year and Date
      2010-10-02
  • [Presentation] STAT6-mediated displacement of Polycomb by Trithorax complex establishes long-term maintenance of GATA3 expression in Th2 cells2010

    • Author(s)
      Onodera, A., Endo, Y. Nakayama, T
    • Organizer
      2010 ASBMB
    • Place of Presentation
      Tahoe City, USA
    • Year and Date
      2010-10-01
  • [Presentation] CD4 T cell memory controlled by Polycomb and Trithorax molecules2010

    • Author(s)
      Nakayama, T
    • Organizer
      The 10th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, JAPAN
    • Year and Date
      2010-09-10
  • [Presentation] 免疫記憶、ポリコ.ムとトライソラックスによる制御2010

    • Author(s)
      中山俊憲
    • Organizer
      第4回日本エピジェネティクス研究会
    • Place of Presentation
      米子
    • Year and Date
      2010-05-29
  • [Patent(Industrial Property Rights)] 関節リウマチに対する抗IL-6受容体抗体療法の有効性の予測方法2011

    • Inventor(s)
      中島裕史(国立大学法人千葉大学大学院), 池田啓(国立大学法人千葉大学大学院), 加々美新一郎( 国立大学法人千葉大学大学院), 鈴木快枝(国立大学法人千葉大学大学院), 中山俊憲(国立大学法人千葉大学大学院), 岩本逸夫, 古田俊介, 小原收(財団法人かずさディー・エヌ・エー研究所), 野中謙, 山下政克(財団法人かずさディー・エヌ・エー研究所), 的場亮
    • Industrial Property Rights Holder
      国立大学法人千葉大学、財団法人かずさディー・エヌ・エー研究所
    • Industrial Property Number
      日本特願、2011-156921
    • Filing Date
      2011-07-14
  • [Patent(Industrial Property Rights)] INHIBITION OF CD69 FOR TREATMENT OF INFRAMMATORY CONDITIONS2010

    • Inventor(s)
      中山俊憲(国立大学法人千葉大学), 長谷川明洋(国立大学法人山口大学), 白井睦訓国立大学法人山口大学)
    • Industrial Property Rights Holder
      国立大学法人千葉大学・国立大学法人山口大学
    • Industrial Property Number
      米国レギュラー出願、US12/945153
    • Filing Date
      2010-11-12
    • Overseas

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Published: 2013-07-31  

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