Intracellularsignals regulating cytokine production in basophils

2012 Fiscal Year Final Research Report

• Project/Area Number: 21390149
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Shinshu University
• Principal Investigator: TAKI Shinsuke 信州大学, 医学部, 教授 (50262027)
• Co-Investigator(Renkei-kenkyūsha): HIDA Shigeaki 信州大学, 医学系研究科, 准教授 (10345762) ; SANJO Hideki 信州大学, 医学部, 助教 (50391967)
• Project Period (FY): 2009 – 2012
• Keywords: アレルギー / サイトカイン / 好塩基球

Research Abstract

Mechanisms regulating interleukin-4 (IL-4) production in murine basophils were studied. Basophils, when resting,produce IL-4 in response to IL-3 but not F_RI crosslinkage, whereas activated basophils produce the cytokine upon FcεRI crosslinkage but not IL-3 stimulation. The transcriptional repressor Bcl-6 and the suppressive cell surface molecule PIR-B were identified to negatively regulate F_RI signals in resting basophils and IL-3 signals in activated basophils, respectively.

Research Products

• [Journal Article] IL-15 とNK細胞の発生・分化・ホメオスタシス (2013)
  • Author(s): 瀧伸介
  • Journal Title: 臨床免疫・アレルギー科 Volume: 59 Pages: 140-146
• [Journal Article] IRF-2 regulates B cell proliferation and antibody production through distinctmechanisms. (2012)
  • Author(s): Minamoto K, Takahara K, Adachi T, Nagaoka K, Iyoda T, Taki S,Inaba K
  • Journal Title: Int Immunol Volume: 24 Pages: 573-581
  • DOI: DOI:10.1093/intimm/dxs060
  • Peer Reviewed
• [Journal Article] Differential requirements for IFN regulatory factor-2 in generation of CD1d-independent T cells bearing NK cell receptors (2012)
  • Author(s): Notake T, Horisawa S, Sanjo H, Miyagawa S, Hida S, Taki S.
  • Journal Title: J. Immunol Volume: 188 Pages: 4838-4845
  • DOI: DOI:10.4049/jimmunol.1200210
  • Peer Reviewed
• [Journal Article] IL-15-high-responder developing NK cells bearing Ly49 receptors in IL-15-/- mice (2011)
  • Author(s): o sh izawa K, Nakajima S, Notake S, Miyagawa S, Hida S, Taki, S
  • Journal Title: J. Immunol Volume: 187 Pages: 5162-5169
  • DOI: DOI:10.4049/jimmunol.1101561
  • Peer Reviewed
• [Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischaemia. (2011)
  • Author(s): Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H, Nishiyama A, Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U
  • Journal Title: Cardiovasc Res Volume: 90 Pages: 362-372
  • DOI: DOI:10.1093/cvr/cvq397
  • Peer Reviewed
• [Journal Article] 活性化T 細胞におけるNKレセプターの発現 (2011)
  • Author(s): 野竹剛、瀧伸介
  • Journal Title: 臨床免疫・アレルギー科 Volume: 55 Pages: 475-482
• [Journal Article] Potentiation of TLR9 responses for human naive B-cell growth through RP105 signaling (2010)
  • Author(s): Yamazaki K, Yamazaki T, Taki S, Miyake K, Hayashi T, Ochs HD, Agematsu K
  • Journal Title: J. Clin. Immunol. Volume: 135 Pages: 125-136
  • DOI: DOI:10.1016/j.clim.2009.12.013
  • Peer Reviewed
• [Journal Article] 好塩基球におけるIL-4産生誘導シグナル伝達機構とTh2分化 (2010)
  • Author(s): 小田朗永、瀧伸介
  • Journal Title: 臨床免疫・アレルギー科 Volume: 54 Pages: 546-553
• [Journal Article] Th2 分化と好塩基球 (2010)
  • Author(s): 肥田重明、瀧伸介
  • Journal Title: 実験医学 Volume: 28 Pages: 1879-1884
• [Journal Article] 好塩基球からのIL-4産生誘導機序 (2010)
  • Author(s): 肥田重明、瀧伸介
  • Journal Title: 炎症と免疫 Volume: 18 Pages: 9-13
• [Journal Article] STAT6 signalling is important in CD8+T-cell activation and defence against Toxoplasma gondii infection in the brain. (2009)
  • Author(s): Jin D, Takamoto M, Hu T, Taki S, Sugane K
  • Journal Title: Immunology Volume: 127 Pages: 187-195
  • DOI: DOI:10.1111/j.1365-2567.2008.02935.x
  • Peer Reviewed
• [Journal Article] Distinct response in maintenance of human naive and memory B cells via IL-21 receptor and TCL1/Akt pathways (2009)
  • Author(s): Nagumo H, Abe J, Kano H, Taki S, Yamazaki K, Yamazaki T, Kobayashi N, Koike K, Sugane K, Saito H, Agematsu K
  • Journal Title: Cell. Immunol. Volume: 256 Pages: 56-63
  • DOI: DOI:10.1016/j.cellimm.2009.01.005
  • Peer Reviewed
• [Journal Article] Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. (2009)
  • Author(s): Hida S. Yamasaki S, Sakamoto Y, Takamoto M, Obata K, Takai T, Karasuyama H, Sugane K, Saito T, Taki S
  • Journal Title: Nature Immunol Volume: 10 Pages: 214-222
  • DOI: DOI:10.1038/ni.1686
  • Peer Reviewed