2011 Fiscal Year Final Research Report
MicroRNAs as biomarkers for drug-induced liver injury
| Project/Area Number |
21390174
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKAMI Tatsuki 金沢大学, 薬学系, 助教 (00532300)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 薬物誘導性肝障害 / マイクロRNA / チトクロムP450 / 転写因子 |
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| Research Abstract |
Because of the significant adverse drug reactions associated with hepatotoxicity, several drugs have been removed from the pharmaceutical market. In most cases, the mechanisms of the hepatotoxicity are unknown and predictive experimental animal models are lacking. Thus, experimental animal models of drug-induced liver injury will enable to perform comprehensive analyses for predictive toxicity studies. The miRNA research in the metabolism of xenobiotics and endobiotics and in toxicology has only recently been established. We performed studies with the following titles,(1) Establishment of halothane-induced liver injury in mice and involvement of miRNA on early onset of liver injury.(2) Involvement of immune-related factors and miRNA in the mouse model of diclofenac-induced liver injury.(3) Establishment of the mouse model of flucloxacillin-induced liver injury.(4) Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis.(5) Peroxisome proliferator-activator receptor. is regulated by miR-21 and miR-27b in human liver
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[Presentation] Human PPARa is regulated by miR-212010
Author(s)
Katsuhiko Kida, Miki Nakajima, Takuya Mohri, Yuki Oda, Shingo Tagagi, Tatsuki Fukami, and Tsuyoshi Yokoi
Organizer
9th International ISSX Meeting
Place of Presentation
Istanbul Conventin & Exihition Center, Istanbul-Tukey
Year and Date
20100904-08
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