2011 Fiscal Year Final Research Report
Clarification of the genes involved in the hyperlipidemia and the application to the preventive medicine
| Project/Area Number |
21390188
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DOUMAE Sumiko 名古屋市立大学, 大学院・医学研究科, 准教授 (70227700)
EBOSHIDA Akira 広島大学, 大学院・医歯(薬)学総合研究科, 教授 (50168811)
FUJIMOTO Nariaki 広島大学, 原爆放射線医科学研究所, 准教授 (40243612)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 衛生 / 予防医学 / 脂質 / 高脂血症 / レステロール / ゲノム / 遺伝子 / ジーントラップ |
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| Research Abstract |
To clarify the genes involved in hypelipidemia (hypercholesterolemia), we conducted a functional genetic screening of the genes that play an important role in intra-cellular cholesterol transport and/or metabolism. So far we succeeded to isolate 188 mutants that defected the LDL-cholesterol uptake, intracellular cholesterol transport and/or metabolism from the large-scale gene-trap insertional mutants library of CHO cells, and to identify the 49 known genes and 32 genes of unidentified function.
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[Journal Article] The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor αchain gene between atopic dermatitis and Japanese cedar pollinosis2012
Author(s)
Tanaka T, Hitomi Y, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata S, SugimotoS, Hatta K, Eboshida A, Konoshita T, Nakamura H
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Journal Title
Allergol Int
Volume: 61巻
Pages: 57-63
DOI
Peer Reviewed
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[Journal Article] Pharmacological inhibition of ABC A1 degradation increases HDL biogenesis and exhibits antiatherogenesis2009
Author(s)
Arakawa R, Tsujita M, Iwamoto N, Ito-Ohsumi C, Lu R, Wu CA, Shimizu K, Aotsuka T, Kanazawa H, Abe-Dohmae S, Yokoyama S.
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Journal Title
J Lipid Res.
Volume: 50巻
Pages: 2299-2305
DOI
Peer Reviewed
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