2011 Fiscal Year Final Research Report
Analysis of usefulness of the susceptible mouse strain in higher functional toxicity evaluation of environmental chemicals
| Project/Area Number |
21390198
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | National Institute for Environmental Studies |
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Principal Investigator |
FUJIMAKI Hidekazu 独立行政法人国立環境研究所, 環境リスク研究センター, 主席研究員 (00124355)
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| Co-Investigator(Kenkyū-buntansha) |
TIN-TIN Win-shwe 独立行政法人国立環境研究所, 環境健康研究センター, 研究員 (00391128)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 産業衛生 |
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| Research Abstract |
Using the animal model developed by exposure research of volatile organic compounds, the effects of different chemical on inflammatory response in higher functions were investigated and compared to toluene for verification the usefulness of elucidation of hypersensitivity and searching new biomarkers. It was the same as that of the result of toluene exposure, diazinon exposure during neonatal period affects the nervous and immune functions in later life. Furthermore, the present study showed a new finding indicating that a different pattern of higher functions was found in neonatal diazinon exposure.
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