Aiming at a new development of the postmortem diagnosis of the drug-related cadaver : Investigation of genetic background

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390218
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Fukuoka University
• Principal Investigator: KUBO Shin-ichi 福岡大学, 医学部, 教授 (10205122)
• Co-Investigator(Kenkyū-buntansha): HARA Kenji 福岡大学, 医学部, 講師 (00090738) ; KASHIWAGI Masayuki 福岡大学, 医学部, 助教 (70301687) ; MATSUSUE Aya 福岡大学, 医学部, 助教 (70309920) ; WATERS Brian 福岡大学, 医学部, 助教 (00609480)
• Project Period (FY): 2009 – 2011
• Keywords: 法医学 / 覚醒剤 / 死因 / 横紋筋融解症 / 遺伝子 / 変異

Research Abstract

There is a possibility that rhabdomyolysis related to drug can be caused by genetic background. We analyzed potential rhabdomyolysis-susceptibility genes in autopsy cases of drug poisoning such as methamphetamine. Some mutations were found, then, using algorithms analysis, several mutation were considered potentially to impact on protein function. These results reveal the possibility that the onset of rhabdomyolysis is associated with both the mutation in the rhabdomyolysis-susceptibility gene and the concentration of methamphetamine or the hyperthermia induced by methamphetamine. A lot more autopsy cases of rhabdomyolysis were required and investigation of other rhabdomyolysis-susceptibility genes helps to clear association between rhabdomyolysis and genetic background.

Research Products

• [Journal Article] Genetic analysis of the rhabdomyolysis-associated genes in forensic autopsy cases of methamphetamine abusers (2011)
  • Author(s): Matsusue A, Hara K, Kashiwagi M, Kageura M, Sugimura T, Kubo S.
  • Journal Title: Leg Med Volume: 13(1) Pages: 7-11
  • Peer Reviewed
• [Journal Article] An autopsy case of rhabdomyolysis related to vegetamin and genetic analysis of the rhabdomyolysis-associated genes (2010)
  • Author(s): Matsusue A, Hara K, Kageura M, Kashiwagi M, Wang L, Ishigami A, Gotohda T, Tokunaga I, Nisimura A, Sugimura T, Kubo S.
  • Journal Title: J Forensic Leg Med Volume: 17(1) Pages: 46-9
  • Peer Reviewed
• [Journal Article] Genetic analysis of ryanodine receptor 1 gene and carnitine palmitoyltransferase II gene : An autopsy case of neuroleptic malignant syndrome related to vegetamin (2009)
  • Author(s): Matsusue A, Hara K, Kageura M, Kashiwagi M, Wang L, Ishigami A, Gotohda T, Tokunaga I, Nisimura A, Sugimura T, Kubo S.
  • Journal Title: Leg Med Volume: 11 Pages: S507-2
  • Peer Reviewed
• [Presentation] Investigation of amphetamines induced rhabdomyolysis and its genetic background (2011)
  • Author(s): Kubo S.
  • Organizer: 8th International Symposium Advances in Legal Medicine
  • Place of Presentation: Frankfurt am Main, Germany
  • Year and Date: 2011-09-27
• [Presentation] Genetic analysis of the four rhabdomyolysis-associated genes in 18 forensic autopsy cases of methamphetamine abusers (2011)
  • Author(s): Matsusue A, Hara K, Kashiwagi M, Waters B, Sugimura T, Kubo S.
  • Organizer: 8th International Symposium Advances in Legal Medicine
  • Place of Presentation: Frankfurt am Main, Germany
  • Year and Date: 2011-09-27
• [Presentation] Genetic analysis of the rhabdomyolysis-associated genes and immunohistochemical study of myoglobin in the kidney in autopsy cases of methamphetamine abusers (2010)
  • Author(s): Matsusue A, Hara K, Kashiwagi M, Kageura M, Sugimura T, Kubo S.
  • Organizer: 48th TIAFT
  • Place of Presentation: Bonn
  • Year and Date: 2010-09-01
• [Presentation] Genetic analysis of ryanodine receptor 1 gene and carnitine palmitoyltransferase II gene. An autopsy case of neuroleptic malignant syndrome related to vegetamin (2009)
  • Author(s): Matsusue A, Hara K, Kageura M, Kashiwagi M, Wang L, Ishigami A, Gotohda T, Tokunaga I, Sugimura T, Kubo S.
  • Organizer: 7th International Symposium on Advances in Legal Medicine
  • Place of Presentation: Lisbon
  • Year and Date: 2009-05-28