Mechanism of sensory dysfunction of swallowing in elderly people and its applied regenerative therapy

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390219
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: EBIHARA Satoru 東北大学, 病院, 講師 (90323013)
• Co-Investigator(Renkei-kenkyūsha): WAKAMORI Minoru 東北大学, 歯学研究科, 教授 (50222401)
• Project Period (FY): 2009 – 2011
• Keywords: 嚥下反射障害 / 抗誤嚥薬 / 温度感受性TRP受容体

Research Abstract

We found that dysphagia in elderly is mainly due to dysfunction of thermosensing TRP channels. In order to regenerate the function of thermosensing TRP channels, we developed methods to regenerate TRPV1 response using capsiate, non-pungent TRPV1 agonist, and red wine polyphenols, a TRPV1 modulator. By combining methods to regenerate thermosensing TRP channels, we developed a protocol to start eating more efficiently and safely in fasted patients with aspiration pneumonia. Using this protocol, the incidence of pneumonia and the number of febrile days for 1 mont h from the start of oral intake were significantly reduced.

Research Products

• [Journal Article] Urge-to-cough and dyspnea conceal perception of pain in healthy adults (2012)
  • Author(s): Gui P, Ebihara S, Ebihara T, Kanezaki M, Kashiwazaki N, Ito K, Kohzuki M
  • Journal Title: Respir Physiol Neurobiol Volume: 181 Pages: 214-219
  • Peer Reviewed
• [Journal Article] Effect of cigarette smoking on cough reflex induced by TRPV1 and TRPA1 stimulations (2012)
  • Author(s): Kanezaki M, Ebihara S, Gui P, Ebihara T, Kohzuki M
  • Journal Title: Respir Med Volume: 106 Pages: 406-12
  • Peer Reviewed
• [Journal Article] Adiponectin Pathway Attenuates Malignant Mesothelioma Cell Growth (2012)
  • Author(s): Niu K, Asada M, Okazaki T, Yamanda S, Ebihara T, Guo H, Zhang D, Nagatomi R, Arai H, Kohzuki M, Ebihara S
  • Journal Title: Am J Respir Cell Mol Biol Volume: 46 Pages: 515-23
  • Peer Reviewed
• [Journal Article] Effect of Aging on Cough and Swallowing Reflexes : Implications for Preventing Aspiration Pneumonia (2011)
  • Author(s): Ebihara S, Ebihara T, Kohzuki M
  • Journal Title: Lung Volume: 190 Pages: 29-33
  • Peer Reviewed
• [Journal Article] Stimulating oral and nasal chemoreceptors for preventing aspiration pneumonia in the elderly (2011)
  • Author(s): Ebihara S, Ebihara T, Yamasaki M, Kohzuki M
  • Journal Title: Yakugaku Zasshi Volume: 131 Pages: 1677-81
  • Peer Reviewed
• [Journal Article] Sensory stimulation to improve swallowing reflex and prevent aspiration pneumonia in elderly dysphagic people (2011)
  • Author(s): Ebihara S, Kohzuki M, Sumi Y, Ebihara T
  • Journal Title: J Pharmacol Sci Volume: 115 Pages: 99-104
  • Peer Reviewed
• [Journal Article] Cough in the elderly : a novel strategy for preventing aspiration pneumonia (2011)
  • Author(s): Ebihara S, Ebihara T
  • Journal Title: Pulm Pharmacol Ther Volume: 24 Pages: 318-323
  • Peer Reviewed
• [Journal Article] Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers (2011)
  • Author(s): Ebihara S, Ebihara T, Kanezaki M, Gui P, Yamasaki M, Arai H, Kohzuki M
  • Journal Title: Cough Volume: 7 Pages: 3
  • Peer Reviewed
• [Journal Article] Impact of physical activity and performance on medical care costs among the Japanese elderly (2011)
  • Author(s): Yang G, Niu K, Fujita K, Hozawa A, Ohmori-Matsuda K, Kuriyama S, Nakaya N, Ebihara S, Okazaki T, Guo H, Miura C, Takahashi H, Arai H, Tsuji I, Nagatomi R
  • Journal Title: Geriatr Gerontol Int Volume: 11 Pages: 157-65
  • Peer Reviewed
• [Journal Article] Infectious disease in the aging (2011)
  • Author(s): Ebihara S
  • Journal Title: Lancet Infect Dis Volume: 11 Pages: 271
• [Journal Article] Missing centenarians in Japan : a new ageism (2010)
  • Author(s): Ebihara S, Freeman S, Ebihara T, Kohzuki M
  • Journal Title: Lancet Volume: 376 Pages: 1739
  • Peer Reviewed
• [Journal Article] Low serum 1, 25-dihydroxyvitamin D level and risk of respiratory infections in institutionalized older people (2010)
  • Author(s): Asamura T, Ohrui T, Nakayama K, He M, Yamasaki M, Ebihara T, Ebihara S, Furukawa K, Arai H
  • Journal Title: Gerontology Volume: 56 Pages: 542-543
  • Peer Reviewed
• [Journal Article] Red wine polyphenols and swallowing reflex in dysphagia (2010)
  • Author(s): Ebihara S, Maruyama Y, Ebihara T, Ohshiro T, Kohzuki M
  • Journal Title: Geriatr Gerontol Int Volume: 10 Pages: 329-330
  • Peer Reviewed
• [Journal Article] Bacteriology of aspiration pneumonia due to delayed triggering of the swallowing reflex in elderly patients (2010)
  • Author(s): Yamanda Y, Ebihara S, Ebihara T, Yamasaki M, Arai H, Kohzuki M
  • Journal Title: J Hosp Infect Volume: 74 Pages: 399-401
  • Peer Reviewed
• [Journal Article] Taste disturbance by angiotensin-converting enzyme inhibitor/angiotensin-2 receptor blocker (2010)
  • Author(s): Ebihara S, Kohzuki M
  • Journal Title: Kidney Int Volume: 77 Pages: 649-650
  • Peer Reviewed
• [Journal Article] Intensive stepwise method for oral intake using a combination of transient receptor potential stimulation and olfactory stimulation inhibits the incidence of pneumonia in the dysphagic elderly (2010)
  • Author(s): Ebihara T, Ebihara S, Yamazaki M, Asada M, Yamanda S, and Arai H
  • Journal Title: J Am Geriatr Soc Volume: 58 Pages: 196-198
  • Peer Reviewed
• [Journal Article] Relationship between Peripheral Arterial Disease and Incident Disability among Japanese Elderly : the Tsurugaya Project (2010)
  • Author(s): Nitta A, Hozawa A, Kuriyama S, Nakaya N, Ohmori-Matsuda K, Sone T, Kakizaki M, Ebihara S, Ichiki M, Arai H, Tsuji I
  • Journal Title: J Atheroscler Thrombo Volume: 17 Pages: 1290-1296
  • Peer Reviewed
• [Journal Article] Gender difference in perceptions of urge-to-cough induced by citric acid and dyspnea in healthy never-smokers (2010)
  • Author(s): Gui P, Ebihara S, Kanezaki M, Suda C, Nikkuni E, Ebihara T, Yamasaki M, Kohzuki M
  • Journal Title: Chest Volume: 138 Pages: 1166-1172
  • Peer Reviewed
• [Journal Article] Impact of Nocturia on Bone Fracture and Mortality in Older Individuals : A Japanese Longitudinal Cohort Study (2010)
  • Author(s): Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K, Nakaya N, Kuriyama S, Ebihara S, Nagatomi R, Tsuji I, Arai Y
  • Journal Title: J Urol Volume: 184 Pages: 1413-1418
  • Peer Reviewed
• [Journal Article] Dietary patterns associated with fall-related fracture in elderly Japanese : a population based prospective study (2010)
  • Author(s): Monma Y, Niu K, Iwasaki K, Tomita N, Nakaya N, Hozawa A, Kuriyama S, Takayama S, Seki T, Takeda T, Yaegashi N, Ebihara S, Arai H, Nagatomi R, Tsuji I
  • Journal Title: BMC Geriatr Volume: 10 Pages: 31
  • Peer Reviewed
• [Journal Article] Caregiving Burden for the Oldest Old : A Population Based Study of Centenarian Caregivers in Northern Japan (2010)
  • Author(s): Freeman S, Kurosawa H, Ebihara S, Kohzuki M
  • Journal Title: Arch Gerontol Geriatr Volume: 50 Pages: 282-291
  • Peer Reviewed
• [Journal Article] Perception of urge-to-cough and dyspnea in healthy smokers with decreased cough reflex sensitivity (2010)
  • Author(s): Kanezaki M, Ebihara S, Nikkuni E, Gui P, Suda C, Ebihara T, Yamasaki M, Kohzuki M
  • Journal Title: Cough Volume: 6 Pages: 1
  • Peer Reviewed
• [Journal Article] Effects of capsiate on the triggering of the swallowing reflex in elderly patients with aspiration pneumonia (2010)
  • Author(s): Yamasaki M, Ebihara S, Ebihara T, Yamanda S, Arai H, Kohzuki M
  • Journal Title: Geriatr Gerontol Int Volume: 10 Pages: 107-109
  • Peer Reviewed
• [Journal Article] Understanding the oldest old in northern Japan : An overview of the functional ability and characteristics of centenarians (2010)
  • Author(s): Freeman S, Kurosawa H, Ebihara S, Kohzuki M
  • Journal Title: Geriatr Gerontol Int Volume: 10 Pages: 78-84
  • Peer Reviewed
• [Journal Article] Green tea consumption is associated with depressive symptoms in the elderly (2009)
  • Author(s): Niu K, Hozawa A, Kuriyama S, Ebihara S, Guo H, Nakaya N, Ohmori-Matsuda K, Takahashi H, Masamune Y, Asada M, Sasaki S, Arai H, Awata S, Nagatomi R, and Tsuji I
  • Journal Title: Am J Clin Nutr Volume: 90 Pages: 1615-22
  • Peer Reviewed
• [Journal Article] Olfactory stimuli and enhanced postural stability in older adults, Role of ephrinB2 in non-productive angiogenesis induced by Delta-like 4 blockade (2009)
  • Author(s): Freeman S, Ebihara S, Ebihara T, Niu K, Kohzuki M, Arai H, Butler JP, Yamanda S, Ebihara S, Asada M, Okazaki T, Niu K, Ebihara T, Koyanagi A, Yamaguchi N, Yagita H, Arai H
  • Journal Title: Gait Posture, Blood Volume: 29 113 Pages: 658-660 3631-3639
  • Peer Reviewed
• [Journal Article] Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial NOS and ERK1/2 phosphorylation (2009)
  • Author(s): Asada M, Ebihara S, Yamanda S, Niu K, Okazaki T, Sora I and Arai H
  • Journal Title: Neoplasia Volume: 11 Pages: 408-41
  • Peer Reviewed
• [Presentation] Sex difference in perception of urge-to-cough and dyspnea in healthy never smokers (2011)
  • Author(s): Ebihara S, Ebihara T, Yamasaki M, Qui P, Kohzuki M
  • Organizer: Symposium 5 : Individual Differences in Dyspnea and Respiratory Sensation. 18^<th> Annual Meeting, 30^<th> Symposium on Respiratory Sensation
  • Place of Presentation: St. George Lycabettus Hotel, Athes, Greece
  • Year and Date: 20111002-03
• [Presentation] Effect of aging on cough and the swallowing reflex (2011)
  • Author(s): Ebihara S
  • Organizer: 3^<rd> American Cough Conference
  • Place of Presentation: Affinia Manhattan Hotel, New York, USA
  • Year and Date: 20110610-11
• [Presentation] Aspiration pneumonia in the Elderly (2010)
  • Author(s): Ebihara S
  • Organizer: 7^<th> International Symposium on Respiratory Disease
  • Place of Presentation: Shanghai, China
  • Year and Date: 20101016-17
• [Presentation] Cough in the elderly (2010)
  • Author(s): Ebihara S
  • Organizer: Special lecture of 6^<th> International Cough Symposium 2010
  • Place of Presentation: at National Heart & Lung Institute, Imperial College London, U. K
  • Year and Date: 20100624-26
• [Book] 誤嚥性肺炎と嚥下機能健康長寿ハンドブック (2011)
  • Author(s): 海老原覚
  • Total Pages: 4
  • Publisher: メジカルビュー社
• [Book] 嚥下受容体活性化高齢者の肺炎-治療・リハビリテーション・予防 (2011)
  • Author(s): 海老原覚、海老原孝枝
  • Total Pages: 127-135
  • Publisher: 医薬ジャーナル
• [Book] ブラックペッパー芳香シートにより再誤嚥を予防しえた患者事例でわかる摂食・嚥下リハビリテーション (2011)
  • Author(s): 海老原覚
  • Total Pages: 141-142
  • Publisher: 中央法規
• [Book] 高齢者の口腔ケアと誤嚥の包括的管理臨床リハ (2011)
  • Author(s): 海老原覚
  • Total Pages: 1161-1164
  • Publisher: 医歯薬出版
• [Book] 嚥下困難と抗誤嚥薬内科 (2011)
  • Author(s): 海老原覚、海老原孝枝
  • Total Pages: 983-987
  • Publisher: 南江堂
• [Book] 摂食・嚥下障害日本臨床 (2011)
  • Author(s): 海老原覚、海老原孝枝
  • Total Pages: 517-521
  • Publisher: 日本臨床社
• [Book] 原始感覚賦活による誤嚥性肺炎予防医学のあゆみ (2011)
  • Author(s): 海老原覚
  • Total Pages: 480-485
  • Publisher: 医歯薬出版
• [Book] 誤嚥性肺炎臨床栄養 (2011)
  • Author(s): 海老原覚
  • Total Pages: 627-633
  • Publisher: 医歯薬出版
• [Book] 過換気症候群からだの科学 (2011)
  • Author(s): 海老原覚、海老原孝枝
  • Total Pages: 123-125
  • Publisher: 日本評論社
• [Book] 誤嚥性肺炎の診断と治療の組み立て方Geriatric Medicine (2010)
  • Author(s): 海老原覚、海老原孝枝
  • Total Pages: 1613-1616
  • Publisher: ライフサイエンス社
• [Book] 高次脳機能刺激による誤嚥予防及び誤嚥性肺炎予防Aging & Health (2010)
  • Author(s): 海老原覚
  • Total Pages: 25-27
• [Book] 誤嚥性肺炎高齢者の生活機能総合評価 (2010)
  • Author(s): 海老原覚、海老原孝枝
  • Total Pages: 127-135
  • Publisher: 新興医学出版社
• [Book] 咽頭から食道機能の加齢変化歯科衛生士のための摂食・嚥下リハビリテーション (2010)
  • Author(s): 海老原覚
  • Total Pages: 93-96
  • Publisher: 医歯薬出版株式会社
• [Book] 心臓リハビリ徹底攻略Q & A (2010)
  • Author(s): 海老原覚
  • Total Pages: 93-96
  • Publisher: 中外医学社
• [Book] 慢性閉塞性肺疾患(COPD)リハビリスタッフに求められる薬・栄養・運動の知識 (2010)
  • Author(s): 海老原覚
  • Total Pages: 98-104
  • Publisher: 南江堂
• [Book] 感覚刺激を介する誤嚥性肺炎予防と嚥下障害リハビリテーションリハ医とコメデイカルのための最新リハビリテーション医学 (2010)
  • Author(s): 海老原覚
  • Total Pages: 239-243
• [Book] 高齢者の肺炎と嚥下機能Geriatric Medicine (2010)
  • Author(s): 海老原覚
  • Total Pages: 43-48
  • Publisher: ライフサイエンス
• [Book] 肺炎日本医師会雑誌 (2009)
  • Author(s): 海老原覚
  • Total Pages: 158-160
  • Publisher: メジカルビュー
• [Book] 高齢者の嚥下機能改善に向けて-薬物療法の可能性難病と在宅ケア (2009)
  • Author(s): 海老原覚
  • Total Pages: 55-58
  • Publisher: 日本プランニングセンター
• [Book] 高齢者誤嚥性肺炎の治療法と予防法-感覚刺激を介する新しい概念化学療法の領域 (2009)
  • Author(s): 海老原覚、海老原孝枝
  • Total Pages: 1874-1881
  • Publisher: 医薬ジャーナル社
• [Book] 転倒のバイオメカニクスとそれに基づく予防アパラタスの開発Geriatric Medicine (2009)
  • Author(s): 海老原覚
  • Total Pages: 501-504
  • Publisher: ライフサイエンス
• [Book] 高齢者COPDにおける呼吸機能検査Geriatric Medicine (2009)
  • Author(s): 海老原覚
  • Total Pages: 155-158
  • Publisher: ライフサイエンス
• [Book] 老年医学からのアプローチー在宅ケアにおける現状と問題点 (2009)
  • Author(s): 大類孝, 山崎都, 何梅, 海老原覚, 海老原孝枝, 浅田成紀, 矢満田慎介, 浅村孝昭, 宇根かおり, 吉田元樹, 小坂陽一, 古川勝敏, 荒井啓行
  • Total Pages: 306-308
  • Publisher: 日老医誌
• [Book] 在宅酸素療法および持続的陽圧換気療法による慢性呼吸不全患者の在宅生活自立 (2009)
  • Author(s): 海老原覚
  • Total Pages: 1811-1812
  • Publisher: 第一法規
• [Remarks]
  • URL: http://www.naibu.med.tohoku.ac.jp/