Development of nocturnal triggered blood pressure monitor and international research for its clinical application

2013 Fiscal Year Final Research Report

• Project/Area Number: 21390247
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Jichi Medical University
• Principal Investigator: KARIO KAZUOMI 自治医科大学, 医学部, 教授 (60285773)
• Co-Investigator(Kenkyū-buntansha): HOSHIDE Satoshi 自治医科大学, 医学部, 准教授 (90326851) ; SHIMPO Masahisa 自治医科大学, 医学部, 准教授 (70406049) ; EGUCHI Kazuo 自治医科大学, 医学部, 講師 (80364503) ; KABUTOYA Tomoyuki 自治医科大学, 医学部, 助教 (00458291) ; ISHIKAWA Shizukiyo 自治医科大学, 医学部, 准教授 (70306140)
• Research Collaborator: NAGAI Michiaki 自治医科大学, 医学部, 病院助教 (30719696) ; SHIRASAKI Osamu オムロンヘルスケア株式会社 (80619023) ; KUWABARA Mitsuo オムロンヘルスケア株式会社 (40721973)
• Project Period (FY): 2009-04-01 – 2014-03-31
• Keywords: トリガー血圧計 / 家庭血圧計 / 睡眠時無呼吸症候群 / 夜間低酸素 / 夜間高血圧 / 基底血圧

Research Abstract

We have been trying to develop the blood pressure monitor which detects blood pressure surges induced by sleep apnea episodes in obstructive sleep apnea syndromes. Until now, we have developed the IT-based nocturnal blood pressure monitoring system which detects blood pressure surges by using the signals of oxygen desaturation falls and transmits the data to the data server and analyze and displays these data automatically. By using this system, we have started multi-center clinical research aimed to reveal the relationship between blood pressure surge and cardiovascular risks. Until now, the number of recruiting patients is over 520. Furthermore, we revealed the nighttime dosing of both vasodilating and sympatholytic antihypertensive drugs is effective to reduce blood pressure surge significantly.
And we have also developed the algorithm which detects nocturnal basal blood pressure by using the signals of low heart rate and have started its performance verification.

Research Products

• [Journal Article] Proposal of a new strategy for ambulatory blood pressure profile-based management of resistant hypertension in the era of renal denervation (2013)
  • Author(s): Kario K.
  • Journal Title: Hypertens Res Volume: 36(6) Pages: 478-84
  • DOI: 10.1038/hr.2013.19
  • Peer Reviewed
• [Journal Article] Orthostatic hypertension-a new haemodynamic cardiovascular risk factor (2013)
  • Author(s): Kario K.
  • Journal Title: Nat Rev Nephrol Volume: 9 Pages: 726-738
  • DOI: 10.1038/nrneph.2013.224
  • Peer Reviewed
• [Journal Article] Sleep duration and insomnia in the elderly : Associations with blood pressure variability and carotid artery remodeling (2013)
  • Author(s): Nagai M, Hoshide S, Nishikawa M, Shimada K, Kario K
  • Journal Title: Am J Hypertens Volume: 26 Pages: 981-989
  • DOI: 10.1093/ajh/hpt070
  • Peer Reviewed
• [Journal Article] Masked hypertension defined by home blood pressure monitoring is associated with impaired flow-mediated vasodilatation in patients with cardiovascular risk factors (2013)
  • Author(s): Kabutoya T, Hoshide S, Ogata Y, Eguchi K, Kario K
  • Journal Title: J Clin Hypertens (Greenwich) Volume: 15 Pages: 630-636
  • DOI: 10.1111/jch.12155
  • Peer Reviewed
• [Journal Article] Nighttime home blood pressure and the risk of hypertensive target organ damage (2012)
  • Author(s): Ishikawa J, Hoshide S, Eguchi K, Ishikawa S, Shimada K, Kario K
  • Journal Title: Hypertension Volume: 60 Pages: 921-928
  • URL: http://hyper.ahajournals.org/content/60/4/921.long
  • Peer Reviewed
• [Journal Article] Short sleep duration and type 2 diabetes enhance the risk of cardiovascular events in hypertensive patients (2012)
  • Author(s): Eguchi K, Hoshide S, Ishikawa S, Shimada K, Kario K
  • Journal Title: Diabetes Res Clin Pract Volume: 98 Pages: 518-523
  • DOI: 10.1016/j.diabres.2012.09.014
  • Peer Reviewed
• [Journal Article] Visit-to-visit blood pressure variations : new independent determinants for cognitive function in the elderly at high risk of cardiovascular disease (2012)
  • Author(s): Nagai M, Hoshide S, Ishikawa J, Shimada K, Kario K
  • Journal Title: J Hypertens Volume: 30 Pages: 1556-1563
  • DOI: 10.1097/HJH.0b013e3283552735
  • Peer Reviewed
• [Journal Article] Development and clinical application of a new technique for detecting 'sleep blood pressure surges' in sleep apnea patients based on a variable desaturation threshold (2011)
  • Author(s): Shirasaki O, Kuwabara M, Saito M, Tagami K, Washiya S, Kario K
  • Journal Title: Hypertens Res Volume: 34(8) Pages: 922-8
  • DOI: 10.1038/hr.2011.52
  • Peer Reviewed
• [Presentation] Poster Session : Hypertension: Clinical - Drug treatment, measurement and blood pressure " Effects of nighttime single-dose administration of vasodilating vs sympatholytic antihypertensives on sleep blood pressure in hypertensives with sleep apnea syndrome -a crossover study-" (2013)
  • Author(s): Kario K.
  • Organizer: American Heart Association, Scientif ic Sessions 2013
  • Place of Presentation: Dallas, Texas
  • Year and Date: 2013-11-19
• [Presentation] Breakfast Workshop: Morning blood pressure rise revisited Morning blood pressure surge : methodological and clinical aspects (2009)
  • Author(s): Kario K.
  • Organizer: 19th European Meeting on Hypertension
  • Place of Presentation: Milan
  • Year and Date: 2009-06-13
• [Presentation] ESH Working Group Symposium : Working Group on Hypertension in Diabetes Effects on ambulatory BP and diabetes on target organ damage and CV disease (2009)
  • Author(s): Kario K.
  • Organizer: 19th European Meeting on Hypertension
  • Place of Presentation: Milan
  • Year and Date: 2009-06-13
• [Patent(Industrial Property Rights)] 心血管リスク評価装置 (2011)
  • Inventor(s): 白崎 修, 桑原 光巨, 苅尾 七臣
  • Industrial Property Rights Holder: 自治医科大学, オムロンヘルスケア株式会社
  • Industrial Property Rights Type: 特許権
  • Industrial Property Number: 特願2011-115845
  • Filing Date: 2011-05-24
• [Patent(Industrial Property Rights)] 血圧測定装置 (2011)
  • Inventor(s): 白崎 修, 渡邉 孝史, 桑原光巨, 苅尾 七臣
  • Industrial Property Rights Holder: 自治医科大学, オムロンヘルスケア株式会社
  • Industrial Property Rights Type: 特許権
  • Industrial Property Number: 特願2011-115846
  • Filing Date: 2011-05-24