2011 Fiscal Year Final Research Report
Analysis of cancer metastasis using circulating tumor cells purified by micro-fluidics techniques
| Project/Area Number |
21390257
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Maozumi 名古屋大学, 医学部附属病院, 助教 (30378020)
KONDO Masashi 名古屋大学, 医学部附属病院, 講師 (00378077)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 循環血液中癌細胞 / マイクロフルイディクス / 肺癌 / 上皮間葉系細胞転換 |
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| Research Abstract |
To investigate the mechanisms and the search of the molecular targets for lung cancer metastasis, we developed the methods for purifying the circulating tumor cells(CTC) from peripheral blood, and we created the prototype device using the nanopillar technique. We also investigated the genetic profiles of CTC, and selected the genes, which were characteristic for CTC. EMT regulatory molecules of ZEB1 and Twist will become molecular targets for lung cancer metastasis.
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