2011 Fiscal Year Final Research Report
Elucidating molecular pathology of glial cells in amyotrophic lateral sclerosis
| Project/Area Number |
21390274
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YAMANAKA Koji 独立行政法人理化学研究所, 運動ニューロン変性研究チーム, チームリーダー (80446533)
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| Co-Investigator(Kenkyū-buntansha) |
MISAWA Hidemi 慶応義塾大学, 薬学部, 教授 (80219617)
KUROKAWA Yoichi 福井県立大学, 生物資源学部, 講師 (40326088)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Hirofumi 独立行政法人理化学研究所, 運動ニューロン変性研究チーム, 研究員 (60402913)
WATANABE Shoji 独立行政法人理化学研究所, 運動ニューロン変性研究チーム, 研究員 (80462745)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経変性疾患 / グリア / 筋萎縮性側索硬化症 |
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| Research Abstract |
In this research program, the role of the candidate genes linked to the glial pathology in amyotrophic lateral sclerosis mouse model was examined. Mice deficient ofα7-nAChR gene showed slowing late disease progression in ALS mice. Moreover, ES-derived motor neuron culture and plant-derived chemical library were established as tools for investigating glial pathology in vitro.
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