Leukemogenesis caused by dysfunction of hematopoietic GATA factors

2012 Fiscal Year Final Research Report

• Project/Area Number: 21390288
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Tohoku University
• Principal Investigator: SHIMIZU Ritsuko 東北大学, 大学院・医学系研究科, 教授 (40226262)
• Project Period (FY): 2009 – 2012
• Keywords: 血液腫瘍学 / 転写因子

Research Abstract

GATA1 is a transcription factor essential for erythroid/megakaryocytic cell differentiation. We found that three elements within promoter-proximal enhancer differentially contribute to spatio-temporal expression of the Gata1 gene in vivo. In addition, we found that loss of the GATA1-FOG1 interaction causes a unique combination of membrane protein deficiency, leading to the hemolysis. We also found that GATA1 has two independent transactivation domains, N-TAD and C-TAD, and both retain redundant as well as specific activities for proper hematopoiesis in vivo.

Research Products

• [Journal Article] Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome (2013)
  • Author(s): Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Yamamoto M, Shimizu R, Ito E.
  • Journal Title: Blood Volume: 121(16) Pages: 3181-3184
  • DOI: doi:10.1182/blood-2012-01-405746
  • Peer Reviewed
• [Journal Article] Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling (2013)
  • Author(s): Guiu J, Shimizu R. D'Altri T,Fraser ST, Hatakeyama J, Bresnick EH, Kageyama R, Dzierzak E, Yamamoto M, Espinosa L, Bigas A.
  • Journal Title: J Exp Med Volume: 210(1) Pages: 71-84
  • DOI: DOI:10.1084/jem.20120993
  • Peer Reviewed
• [Journal Article] N- and C-terminal transactivation domains of GATA1 protein coordinate hematopoietic program (2012)
  • Author(s): Kaneko H, Kobayashi E, Yamamoto M, Shimizu R
  • Journal Title: J Biol Chem Volume: 287(25) Pages: 21439-21449
  • DOI: doi:10.1074/jbc.M112.370437
  • Peer Reviewed
• [Journal Article] UG4 enhancer-driven GATA-2 and BMP4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice (2012)
  • Author(s): Ainoya K, Moriguchi T, Ohmori S, Souma, T. Takai J, Morita M, Chandler KJ, Mortlock DP, Shimizu R, Lim, KC, Engel JD, Yamamoto M
  • Journal Title: Mol Cell Biol Volume: 32(12) Pages: 2312-2322
  • DOI: doi:10.1128/MCB.06699-11
  • Peer Reviewed
• [Journal Article] Mature erythrocyte membrane homeostasis is compromised by loss of the GATA1-FOG1 interaction (2012)
  • Author(s): Hasegawa A, Shimizu R, Mohandas N, Yamamoto M
  • Journal Title: Blood Volume: 119(11) Pages: 2615-2623
  • DOI: doi:10.1182/blood-2011-09-382473
  • Peer Reviewed
• [Journal Article] The contribution of GATA1 dysfunction to multi-step leukemogenesis (2012)
  • Author(s): Shimizu R, Yamamoto M
  • Journal Title: Cancer Sci Volume: 103(12) Pages: 2039-2044
  • DOI: DOI:10.1111/cas.12007
  • Peer Reviewed
• [Journal Article] Protective role of Nrf2 inage-related hearing loss and gentamicin ototoxicity (2011)
  • Author(s): Hoshino T, Tabuchi K, Nishimura B, Tanaka S, Nakayama M, Ishii T, Warabi E,Yanagawa T, Shimizu R, Yamamoto M, Hara A
  • Journal Title: Biochem Biophys Res Commun Volume: 415(1) Pages: 94-98
  • DOI: doi:10.1016/j.bbrc.2011.10.019
  • Peer Reviewed
• [Journal Article] The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice (2011)
  • Author(s): Tatsumi K, Yamamoto-Mukai H, Shimizu R, Waguri S, Sou YS, Sakamoto A, Taya C, Shitara H, Hara T, Chung CH, Tanaka K, Yamamoto M, Komatsu M.
  • Journal Title: Nat Commun 2 Article number Volume: 181
  • DOI: doi:10.1038/ncomms1182
  • Peer Reviewed
• [Journal Article] Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia (2011)
  • Author(s): Kawatani Y, Suzuki T, Shimizu R, Kelly V, Yamamoto M
  • Journal Title: Blood Volume: 117(3) Pages: 986-996
  • DOI: doi:10.1182/blood-2011-09-382473
  • Peer Reviewed
• [Journal Article] Transcriptional regulation by GATA1 and GATA2 during erythropoiesis (2011)
  • Author(s): Suzuki M, Shimizu R, Yamamoto M.
  • Journal Title: Int J Hematol Volume: 93(2) Pages: 150-155
  • DOI: doi:10.1007/s12185-011-0770-6
  • Peer Reviewed
• [Journal Article] GATA1転写因子の機能異常と白血病 (2011)
  • Author(s): 清水律子
  • Journal Title: 臨床血液 Volume: 52(8) Pages: 695-702
  • Peer Reviewed
• [Journal Article] Dual-color luciferase mouse directly demonstrates coupled expression of two clock genes (2010)
  • Author(s): Noguchi T, Michihata T, Nakamura W, Takumi T, Shimizu R, Yamamoto M, Ikeda M, Ohmiya Y, Nakajima Y.
  • Journal Title: Biochemistry Volume: 49(37) Pages: 8053-8061
  • DOI: DOI:10.1021/bi100545h
  • Peer Reviewed
• [Journal Article] Loss of the Gata1 gene IE exon leads to variant transcript expression and the production of a GATA1 protein lacking the N-terminal domain (2010)
  • Author(s): Kobayashi E, Shimizu R, Kikuchi Y, Takahashi S, Yamamoto M.
  • Journal Title: J Biol Chem Volume: 285(1) Pages: 773-783
  • DOI: doi:10.1074/jbc.M109.030726
  • Peer Reviewed
• [Journal Article] GATA Factor switching during erythroid differentiation (2010)
  • Author(s): Kaneko H, Shimizu R, Yamamoto M.
  • Journal Title: Curr Opin Hematol Volume: 17(3) Pages: 163-168
  • DOI: doi:10.1097/MOH.0b013e32833800b8
  • Peer Reviewed
• [Journal Article] Induction of hyperproliferative fetal megakaryopoiesis by an N-terminally truncated GATA1 mutant (2009)
  • Author(s): Shimizu R, Kobayashi E, Engel JD, Yamamoto M.
  • Journal Title: Gene Cells Volume: 14(9) Pages: 1119-1131
  • DOI: doi:10.1111/j.1365-2443.2009.01338.x
  • Peer Reviewed
• [Journal Article] Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis (2009)
  • Author(s): Kadri Z, Shimizu R, Ohneda O, Maouche-Chretien L, Gisselbrecht S, Yamamoto M, Romeo PH, Leboulch P, Chretien S.
  • Journal Title: PLoS Biol Volume: 7(6) Pages: e1000123
  • DOI: doi:10.1371/journal.pbio.1000123
  • Peer Reviewed
• [Journal Article] Leukemia-related transcription factor TEL/ETV6 expands erythroid precursors and stimulates hemoglobin synthesis (2009)
  • Author(s): Eguchi-Ishimae M, Eguchi M, Maki K, Porcher C, Shimizu R, Yamamoto M, Mitani K.
  • Journal Title: Cancer Sci Volume: 100(4) Pages: 689-697
  • DOI: doi:10.1111/j.1349-7006.2009.01097.x
  • Peer Reviewed
• [Journal Article] Stem cells of GATA1-related leukemia undergo pernicious changes after 5-fluorouracil treatment. (2009)
  • Author(s): Abe K. Shimizu R. Pan X, Hamada, H, Yoshikawa H, Yamamoto M.
  • Journal Title: Exp Hematol Volume: 37(4) Pages: 435-445
  • DOI: doi:10.1016/j.exphem.2008.12.004
  • Peer Reviewed
• [Journal Article] 相補レスキュー法を用いた GATA1 転写因子の機能解析- 東北大医保健 (2009)
  • Author(s): 清水 律子
  • Journal Title: 学科紀要 Volume: 18 Pages: 75-81
• [Journal Article] GATA1 関連白血病 (2009)
  • Author(s): 清水 律子
  • Journal Title: 東北医学雑誌 Volume: 121(2) Pages: 165-170
• [Presentation] 転写因子GATA1の機能異常と多段階白血病発症 (2013)
  • Author(s): 清水律子
  • Organizer: 鳥取大学染色体工学研究センターセミナー
  • Place of Presentation: 鳥取大学
  • Year and Date: 2013-02-22
• [Presentation] DNA binding diversity achieved through the interaction of GATA1 N-finger and GATA motif is important for embryonic erythropoiesis (2012)
  • Author(s): Hasegawa A, Shimizu R, Kurokawa H, Yamamoto M.
  • Organizer: 54th ASH Annual Meeting and Exposition, Georgia World Congress Center
  • Place of Presentation: Atlanta,GA, USA
  • Year and Date: 20121008-11
• [Presentation] シス配列多様性に依存したGATA1-DNA結合親和性修飾機構の生理機能解析 (2012)
  • Author(s): 長谷川敦史,清水律子,金子寛,黒河博文,山本雅之
  • Organizer: 平成24年度「転写代謝システム」領域班会議
  • Place of Presentation: つくばグランドホテル、つくば
  • Year and Date: 20120702-04
• [Presentation] Amino- and Carboxyl- terminal transactivation domains of GATA1 coordinate the hematopoietic program (2012)
  • Author(s): Kaneko H, Eri Kobayashi, Shimizu R, Yamamoto M.
  • Organizer: The 18th Conference on Hemoglobin Switching, Asiloma Conference Grounds
  • Place of Presentation: CA, USA
  • Year and Date: 20120608-10
• [Presentation] シス配列多様性に依存した GATA1-DNA 結合親和性修飾機構の生理機能解析 (2012)
  • Author(s): 長谷川敦史, 清水律子 , 金子寛, 黒河博文, 山本雅之
  • Organizer: BIA Symposium 2012 (GE Healthcare)
  • Place of Presentation: 明治記念館、東京
  • Year and Date: 2012-07-20
• [Presentation] 多段階白血病発症に関与する転写因子GATA1の機能解析 (2012)
  • Author(s): 清水律子
  • Organizer: 第4回お茶の水セミナー
  • Place of Presentation: 東京ドームホテル、東京
  • Year and Date: 2012-04-18
• [Presentation] アミノ末端側亜鉛フィンガーによるGATA1-DNA結合親和性修飾機構の解析 (2012)
  • Author(s): 長谷川敦史,清水律子,金子寛,黒河博文,山本雅之
  • Organizer: 東北大学大学院医学系研究科ルネサンス計画事業第5回リトリート大学院生研究発表会東北大学片平キャンパスさくらホール
  • Place of Presentation: 仙台
  • Year and Date: 2012-01-21
• [Presentation] 3q21q26染色体転座モデルマウスを用いた原がん遺伝子Evi1活性化と白血病発症の分子機構の解析 (2011)
  • Author(s): 山嵜博未、鈴木未来子、清水律子、山本雅之
  • Organizer: 第34回日本分子生物学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 20111213-16
• [Presentation] GATA1 mutations lacking Rb-binding motif observed in transient abnormal myelopoiesis in Down Syndrome (2011)
  • Author(s): Toki T, Kobayashi E, Kanezaki R, Wang R, Terui K, Kanezane H, Maeda M, Koike Y, Endo M, Adachi S, Hayashi Y, Shimizu R, Yamamoto M, Ito E.
  • Organizer: The 53rd ASH Annual Meeting,Convention Center
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 20111209-13
• [Presentation] Two distinct transactivation domain of GATA1 contribute megakaryopoiesis (2011)
  • Author(s): Kaneko H, Kobayashi E, Shimizu R, Yamamoto M.
  • Organizer: The 53rd ASH Annual Meeting, Convention Center
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 20111209-13
• [Presentation] Transcription Factor GATA2 Regulates the Differentiation of Mesenchymal Stem Cells (2011)
  • Author(s): Mayumi Kamata, Yoko Okitsu, Tohru Fujiwara, Rie Ohba, Yuna Katsuoka, Noriko Fukuhara, Katura Kohata, Hiroto Ohguchi, Yasushi Onishi, Joji Yamamoto, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae
  • Organizer: 第73回日本血 液学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 20111014-16
• [Presentation] Novel GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome (2011)
  • Author(s): Tsutomu Toki, Eri Kobayashi, Rika Kanezaki, Runan Wang, Kiminori Terui, Hirokazu Kanezane, Miho Maeda, Yakayoshi, Koike, Mikiya Endo, Souichi, Adachi, Yasuhide Hayashi, Ritsuko Shimizu, Masayuki Yamamoto, Etsuro Ito
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 20111014-16
• [Presentation] GATA1 N-terminal zinc finger plays essential roles in hematopoietic development by modifying GATA1-DNA binding (2011)
  • Author(s): 長谷川敦史, 清水 律子 , 金子 寛, 黒河博文, 山本雅之
  • Organizer: 第84回日本生 化学会大会、国立京都国際会館
  • Year and Date: 20110921-24
• [Presentation] Identification and analysis of novel transactivation domain of transcription factor GATA1 (2011)
  • Author(s): 金子寛、小林枝里、清水律子、山本雅之. 平成 23 年度 かん若手研究者ワークショップ
  • Organizer: アートランドホテル蓼科、長野県蓼科
  • Year and Date: 20110831-0903
• [Presentation] ダウン症候群随伴巨核芽球性白血病の分子基盤 (2011)
  • Author(s): 清水律子
  • Organizer: 第58回東北小児白血病研究会、ホテルコムズ仙台
  • Place of Presentation: 仙台
  • Year and Date: 2011-06-04
• [Presentation] 長谷川敦史,清水律子,山本雅之 (2011)
  • Author(s): DNA結合親和性に寄与するGATA1N末端側亜鉛フィンガーの生理的機能解析
  • Organizer: 東北大学大学院医学系研究科ルネサンス計画事業第4回リトリート大学院生研究発表会、東北大学片平キャンパスさくらホール
  • Year and Date: 2011-01-15
• [Presentation] Roles of GATA1/Rb interaction in control of megakaryocyte proliferation (2010)
  • Author(s): Kobayashi E, Shimizu R, Toki T, Ito E, Yamamoto M
  • Organizer: The 5th International Symposium on GATA factors at Tohoku University
  • Place of Presentation: Sendai
  • Year and Date: 20101217-19
• [Presentation] Identification and analysis of novel transactivation domain of transcription factor GATA1 (2010)
  • Author(s): Kaneko H, Kawatani Y, Shimizu R, Yamamoto M
  • Organizer: The 5th International Symposium on GATA factors at Tohoku University
  • Place of Presentation: Sendai
  • Year and Date: 20101217-19
• [Presentation] GATA2 in Urogenital development (2010)
  • Author(s): Moriguchi T, Ainoya K, Ohmori S, Morita M, Chandler KJ, Mortlock DP, Shimizu R, Lim K-C, Engel JD, Yamamoto M.
  • Organizer: The 5th International Symposium on GATA factors at Tohoku University
  • Place of Presentation: Sendai
  • Year and Date: 20101217-19
• [Presentation] Multi-step leukemogenesis caused by N-terminally truncated GATA1 mutants (2010)
  • Author(s): Shimizu R, Kobayashi E, Engel, JD, Yamamoto M.
  • Organizer: The 5th International Symposium on GATA factors at Tohoku University
  • Place of Presentation: Sendai
  • Year and Date: 20101217-19
• [Presentation] Regulation of Gata1 gene in vivo with the cis-acting functional motifs and GATA factor switching (2010)
  • Author(s): Takai J, Moriguchi T, Suzuki M, Ohneda K, Shimizu R, Yamamoto M.
  • Organizer: The 5th International Symposium on GATA factors at Tohoku University
  • Place of Presentation: Sendai
  • Year and Date: 20101217-19
• [Presentation] Spehrocytic hemolytic anemia cased by disruption of GATA1-FOG1 interaction (2010)
  • Author(s): Hasegawa A, Shimizu R, Yamamoto M.
  • Organizer: The 5th International Symposium on GATA factors at Tohoku University
  • Place of Presentation: Sendai
  • Year and Date: 20101117-19
• [Presentation] SUMO-conjugated GATA1 and GATA FactorSwitching (2010)
  • Author(s): Shimizu R, Ohmori S, Hasegawa A, KanekoH, Moriguchi T, Yamamoto M.
  • Organizer: The 17th Conference onHemoglobin Switching at St John's College
  • Place of Presentation: Oxford, UK
  • Year and Date: 20100901-05
• [Presentation] Spherocytic hemolytic anemia caused by disruption of GATA1-FOG1 interaction (2010)
  • Author(s): Shimizu R, Hasegawa A, Yamamoto M.
  • Organizer: The 17th Conference on Hemoglobin Switching at St John's College
  • Place of Presentation: Oxford, UK
  • Year and Date: 20100901-05
• [Presentation] GATA1関連白血病 (2010)
  • Author(s): 清水律子,小林枝里,山本雅之
  • Organizer: 第72回日本血液学会学術集会、シンポジウム
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 20100901-04
• [Presentation] Analysis of the molecular mechanism forleukemogenesis caused by GATA1 mutationon acute megakaryoblastic leukemia (2010)
  • Author(s): 小林枝里、 清水律子 、山本雅之
  • Organizer: 平成22年度がん若手ワークショップ アートランドホテル蓼科
  • Year and Date: 20100901-04
• [Presentation] Spherocytic Hemolytic Anemia Caused by Disruption of GATA1-FOG1 Interaction (2010)
  • Author(s): Hasegawa A, Shimizu R and Yamamoto M.
  • Organizer: JSH International Symposium 2010 in Akita, Akita University
  • Place of Presentation: Akita, Japan
  • Year and Date: 20100716-17
• [Presentation] Compound Deficiency of Nrf2 and Selenoproteins in Hematopoietic Cells Leads to Severe Defects in Erythroid and Lymphoid Lineage Development (2010)
  • Author(s): Kawatani Y, Suzuki T, Shimizu R, Kelly VP, Yamamoto M.
  • Organizer: 9th International Symposium on Selenium in Biology and Medicine
  • Place of Presentation: Kyoto
  • Year and Date: 20100531-0604
• [Presentation] GATA1関連白血病 (2010)
  • Author(s): 清水律子
  • Organizer: 平成22年度造血器腫瘍研究会
  • Place of Presentation: 奈良
  • Year and Date: 20100211-12
• [Presentation] Identification and analysis of novel transactivation domain of transcription factor GATA1 (2010)
  • Author(s): Kaneko H, Kawatani Y, Shimizu R, Yamamoto M.
  • Organizer: 第22回日本分子生物学会第83回日本生化 学会合同大会、神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] 血球分化に果たすGATA1カルボキシル末端領域の機能解析 (2010)
  • Author(s): 金子寛、川谷幸恵、清水律子、山本雅之
  • Organizer: 第76回日本生化学会東北支部会例会、コラッセふくし
  • Year and Date: 2010-05-08
• [Presentation] GATA1関連白血病 (2010)
  • Author(s): 清水律子
  • Organizer: 第33回仙台BMT懇話会
  • Place of Presentation: 特別講演、東北大学
  • Year and Date: 2010-01-18
• [Presentation] GATA1とFOG1の相互作用欠損は溶血性貧血を惹起する (2010)
  • Author(s): 長谷川敦史、清水律子、山本雅之
  • Organizer: 東北大学大学院医学系研究科ルネサンス計画事業第3回リトリート大学院生研究発表会、東北大学さくらホール
  • Place of Presentation: 仙台
  • Year and Date: 2010-01-09
• [Presentation] 転写因子GATA1の突然変異による急性巨核芽球性白血病の発症機序の解析 (2010)
  • Author(s): 小林枝里、清水律子、山本雅之
  • Organizer: 東北大学大学院医学系研究科ルネサンス計画事業第3回リトリート大学院生研究発表会、東北大学片平キャンパスさくらホー
  • Year and Date: 2010-01-09
• [Presentation] 血球分化に果たす転写因子GATA1 C末端領域の機能解析 (2010)
  • Author(s): 金子寛、川谷幸恵、清水律子、山本雅之
  • Organizer: 東北大学大学院医学系研究科ルネサンス計画事業第3回リトリート大学院生研究発表会、東北大学片平キャンパスさくらホール
  • Year and Date: 2010-01-09
• [Presentation] Spherocytic hemolytic anemia caused by disruption of GATA1-FOG1 interaction. (2009)
  • Author(s): Shimizu R, Hasegawa A, Yamamoto M.
  • Organizer: The 51th ASH Annual Meeting, Ernest N. Morial Convention Center
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 20091205-08
• [Presentation] Compound Deficiency of Nrf2 and Selenoproteins in Hematopoietic Cells Leads to Severe Defects in Erythroid and Lymphoid Development (2009)
  • Author(s): Kawatani Y, Suzuki T, Shimizu R, Kelly V, Yamamoto M.
  • Organizer: The 51th ASH Annual Meeting, Ernest N. Morial Convention Center
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 20091205-08
• [Presentation] Loss of the Gata1 Gene IE Exon Leads to Variant Transcript Expression and the Production of a GATA1 Protein Lacking the N-terminal Domain (2009)
  • Author(s): Kobayashi E, Shimizu R, Kikuchi Y, Takahashi S, Yamamoto M.
  • Organizer: The 51th ASH Annual Meeting, Ernest N. Morial Convention Center
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 20091205-08
• [Presentation] GATA1-FOG1相互作用の欠損は溶血性貧血を惹起する (2009)
  • Author(s): 長谷川敦史、清水律子、山本雅之
  • Organizer: 第82回日本生化学会大会、神戸ポートアイランド
  • Year and Date: 20091021-24
• [Presentation] GATA1発現制御における血球特異的第1エキソンの機能 (The function of the hematopoietic first exon in regulation of Gata1 gene expression) (2009)
  • Author(s): 小林枝里、清水律子、菊池優子、高橋智、山本雅之
  • Organizer: 第82回日本生化学会大会、神戸ポートアイランド
  • Year and Date: 20091021-24
• [Presentation] 造血及び白血病発症におけるヒストンアセチル化酵素MOZによる転写因子GATA1/2およびPU.1の制御 (2009)
  • Author(s): 高橋望、吉田尚美、相川祐規子、清水律子、山本雅之、北林一生
  • Organizer: 第68回日本癌学会学術総会、パシフィコ横浜
  • Year and Date: 20091001-03
• [Presentation] 胎児肝巨核球の異常増殖はN末端欠失型GATA1変異により誘導される (2009)
  • Author(s): 清水律子、山本雅之
  • Organizer: 第68回日本癌学会学術総会、パシフィコ横浜
  • Year and Date: 20091001-03
• [Presentation] 造血幹細胞の未分化性維持機構に関わる骨髄ニッチの役割 (2009)
  • Author(s): 清水律子
  • Organizer: 特定領域研究<細胞の運命と挙動を支配する細胞外環境のダイナミズム>京都国際会館
  • Place of Presentation: 京都
  • Year and Date: 20090915-16
• [Presentation] GATA factor switching during erythroid differentiation. Red cell Gordon Conference (2009)
  • Author(s): Yamamoto M, Moriguchi, T, Suzuki, M, and Shimizu R.
  • Organizer: University of New England, Biddeford
  • Place of Presentation: ME,USA
  • Year and Date: 20090628-0703