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2011 Fiscal Year Final Research Report

Functional analysis of NLRR family genes in neuroblastoma

Research Project

  • PDF
Project/Area Number 21390317
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionChiba Cancer Center (Research Institute)

Principal Investigator

NAKAGAWARA Akira  千葉県がんセンター(研究所), 研究局, センター長 (50117181)

Co-Investigator(Kenkyū-buntansha) TAKATORI Atsushi  千葉県がんセンター(研究所), 研究局, 研究員 (40455390)
Co-Investigator(Renkei-kenkyūsha) NAKAMURA Yohko  千葉県がんセンター(研究所), 研究局, 主席研究員 (60260254)
Project Period (FY) 2009 – 2011
KeywordsNLLRR1 / NLRR2 / NLRR3 / Neuroblastoma / 細胞増殖
Research Abstract

The novel human NLRR family genes, which were previously cloned from our cDNA project, were functionally analyzed. NLRR1 was found to enhance cell growth to promote progression of neuroblastoma. The knockout mice we generated proved that NLRR1 suppresses the cell growth signals through the function of lipid raft. We have successfully generated anti-NLRR1 monoclonal antibodies which can be developed to be therapeutic use. NLRR2 regulated the cell survival signals through induction of ER stress. NLRR3 induced cellular differentiation and was negatively transcribed by MYCN. Thus, NLRR family molecules were found to share their roles to regulate cell functions and to contribute to the clinical behavior of human neuroblastoma.

  • Research Products

    (52 results)

All 2012 2011 2010 2009

All Journal Article (52 results) (of which Peer Reviewed: 51 results)

  • [Journal Article] Inhibitory role of E2F-1 in the regulation of tumor suppressor p53 during DNA damage response2012

    • Author(s)
      Yoshihara Y, Wu D, Kubo N, Sang M, Nakagawara A, Ozaki T
    • Journal Title

      Biochem Biophys Res Commun

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2012.03.108

    • Peer Reviewed
  • [Journal Article] ALK fusion gene positive lung cancer and 3 cases treated with an inhibitor for ALK kinase activity2012

    • Author(s)
      Kimura H, Nakajima T, Takeuchi K, Soda M, Mano H, Iizasa T, Matsui Y, Yoshino M, Shingyoji M, Itakura M, Itami M, Ikebe D, Yokoi S, Kageyama H, Ohira M, Nakagawara A
    • Journal Title

      Lung Cancer

      Volume: 75 Pages: 66-72

    • URL

      http://dx.doi.org/10.1016/j.lungcan.2011.05.027

    • Peer Reviewed
  • [Journal Article] Calreticulin Mediates Nerve Growth Factor-Induced Neuronal Differentiation2011

    • Author(s)
      Shih YY, Nakagawara A, Lee H, Juan HF, Jeng YM, Lin DT, Yang YL, Tsay YG, Huang MC, Pan CY, Hsu WM, Liao YF
    • Journal Title

      J Mol Neurosci

    • DOI

      DOI:10.1007/s12031-011-9683-3

    • Peer Reviewed
  • [Journal Article] Expression of NLRR3 orphan receptor gene is negatively regulated by MYCN and Miz-1, and its down-regulation is associated with unfavorable outcome in neuroblastoma2011

    • Author(s)
      Akter J, Takatori A, Hossain S, Ozaki T, Nakazawa A, Ohira M, Suenaga Y, Nakagawara A
    • Journal Title

      Clin Cancer Res

      Volume: 17 Pages: 6681-6692

    • DOI

      DOI:10.1158/1078-0432.CCR-11-0313

    • Peer Reviewed
  • [Journal Article] A novel role of RUNX3 in the regulation of p53-mediated apoptosis in response to DNA damage2011

    • Author(s)
      Ozaki T, Yamada C, Nakagawara A
    • Journal Title

      Seikagaku

      Volume: 83 Pages: 751-754

    • Peer Reviewed
  • [Journal Article] Prognostic Value of the Stage 4S Metastatic Pattern and Tumor Biology in Patients With Metastatic Neuroblastoma Diagnosed Between Birth and 18 Months of Age2011

    • Author(s)
      Taggart DR, De Bernardi B, Ambros PF, Pearson AD, Cohn SL, Matthay KK London WB, Schmidt ML, Dubois SG, Monclair TF, Nakagawara A
    • Journal Title

      J. Clin. Oncol

      Volume: 29 Pages: 4358-4364

    • DOI

      DOI:10.1200/JCO.2011.35.9570

    • Peer Reviewed
  • [Journal Article] Nuclear GRP75 Binds Retinoic Acid Receptors to Promote Neuronal Differentiation of Neuroblastoma2011

    • Author(s)
      Shih YY, Lee H, Nakagawara A, Juan HF, Jeng YM, Tsay YG, Lin DT, Hsieh FJ, Pan CY, Hsu WM, Liao YF
    • Journal Title

      PLoS One

      Volume: 6(10) Pages: e26236

    • DOI

      DOI:10.1371/journal.pone.0026236

    • Peer Reviewed
  • [Journal Article] The 7th Asia Cancer Forum : from the perspective of human security, how can we collaborate as Asians in order to place cancer on the global health agenda? How can we fill in the gaps that exist among us2011

    • Author(s)
      Kawahara N, Roh JK, Akaza H, Inoue H, Shibuya K, Iwasaki M, Tsuji T, Nishiyama M, Nakagawara A, Watanabe K, Nozaki S, Inoue M, Sugimura H, Miyake J, Li F
    • Journal Title

      Jpn. J. Clin. Oncol

      Volume: 41 Pages: 825-831

    • DOI

      DOI:10.1093/jjco/hyr052

    • Peer Reviewed
  • [Journal Article] Multi-gene mutation analysis of metastatic lymph nodes in non-small cell lung cancer diagnosed by EBUS-TBNA2011

    • Author(s)
      Nakajima T, Yasufuku K, Nakagawara A, Kimura H, Yoshino I
    • Journal Title

      Chest

      Volume: 140 Pages: 1319-1324

    • DOI

      DOI:10.1378/chest.10-3186

    • Peer Reviewed
  • [Journal Article] Clinical and Biologic Features Predictive of Survival After Relapse of Neuroblastoma : A Report From the International Neuroblastoma Risk Group Project2011

    • Author(s)
      London WB, Castel V, Monclair T, Ambros PF, Pearson AD, Cohn SL, Berthold F, Nakagawara A, Ladenstein RL, Iehara T, Matthay KK
    • Journal Title

      J. Clin. Oncol

      Volume: 29 Pages: 3286-3292

    • DOI

      DOI:10.1200/JCO.2010.34.3392

    • Peer Reviewed
  • [Journal Article] Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash12011

    • Author(s)
      Isogai E, Ohira M, Ozaki T, Oba S, Nakamura Y, Nakagawara A
    • Journal Title

      PLoS ONE

      Volume: 6(5) Pages: e19297

    • DOI

      DOI:10.1371/journal.pone.0019297

    • Peer Reviewed
  • [Journal Article] A novel potent tumour promoter aberrantly overexpressed in most human cancers2011

    • Author(s)
      Takahashi A, Tokita H, Takahashi K, Takeoka T, Murayama K, Tomotsune D, Ohira M, Iwamatsu A, Ohara K, Yazaki K, Koda T, Nakagawara A, Tani K
    • Journal Title

      Scientific Reports

      Volume: 1(15) Pages: 06

    • DOI

      DOI:10.1038/srep00015

    • Peer Reviewed
  • [Journal Article] Role of p53 in cell death and human cancers2011

    • Author(s)
      Ozaki T, Nakagawara A
    • Journal Title

      Cancers

      Volume: 3 Pages: 994-1013

    • Peer Reviewed
  • [Journal Article] The 6th Asia Cancer Forum : What Should We Do to Place Cancer on the Global Health Agenda? Sharing Information Leads to Human Security2011

    • Author(s)
      Kawahara N, Sugimura H, Nakagawara A, Masui T, Miyake J, Akiyama M, Wahid IA, Hao X, Akaza H
    • Journal Title

      Jpn. J. Clin. Oncol

      Volume: 1 Pages: 723-729

    • DOI

      DOI:10.1093/jjco/hyr036

    • Peer Reviewed
  • [Journal Article] Bmi1 regulates cell fate via tumor suppressor WWOX repression in small cell lung cancer cells2011

    • Author(s)
      Kimura M, Takenobu H, Akita N, Nakazawa A, Ochiai H, Shimozato O, Fujimura YI, Koseki H, Yoshino I, Kimura H, Nakagawara A, Kamijo T
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 983-990

    • DOI

      DOI:10.1111/j.1349-7006.2011.01891.x

    • Peer Reviewed
  • [Journal Article] CREB represses p53-dependent transactivation of MDM2 through the complex formation with p53 and contributes to p53-mediated apoptosis in response to glucose deprivation2011

    • Author(s)
      Okoshi R, Kubo N, Nakashima K, Shimozato O, Nakagawara A, Ozaki T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 406 Pages: 79-84

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2011.01.114

    • Peer Reviewed
  • [Journal Article] p53 : the attractive tumor suppressor in the cancer research field2011

    • Author(s)
      Ozaki T, Nakagawara A
    • Journal Title

      J. Biomed. Biotechnol

      Volume: 2011 Pages: 603925

    • DOI

      DOI:10.1155/2011/603925

    • Peer Reviewed
  • [Journal Article] The benchmark analysis of gastric, colorectal and rectal cancer pathways : toward establishing standardized clinical pathway in the cancer care2011

    • Author(s)
      Ryu M, Hamano M, Nakagawara A, Shinoda M, Shimizu H, Miura T, Yoshida I, Nemoto A, Yoshikawa A
    • Journal Title

      Jpn. J. Clin. Oncol

      Volume: 41 Pages: 2-9

    • DOI

      DOI:10.1093/jjco/hyq211

    • Peer Reviewed
  • [Journal Article] Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues2011

    • Author(s)
      Iwama E, Tsuchimoto D, Iyama T, Sakumi K, Nakagawara A, Takayama K, Nakanishi Y, Nakabeppu Y
    • Journal Title

      J. Mol. Neurosci

      Volume: 44 Pages: 103-114

    • DOI

      DOI:10.1007/s12031-010-9490-2

    • Peer Reviewed
  • [Journal Article] Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice2011

    • Author(s)
      Zhang L, Haraguchi S, Koda T, Hashimoto K, Nakagawara A
    • Journal Title

      J Biomed. Biotechnol

      Volume: 2011 Pages: 831092

    • DOI

      DOI:10.1155/2011/831092

    • Peer Reviewed
  • [Journal Article] CD133 suppresses neuroblastoma cell differentiation via signal pathway modification2011

    • Author(s)
      Takenobu H, Shimozato O, Nakamura T, Ochiai H, Yamaguchi Y, Ohira M, Nakagawara A, Kamijo T
    • Journal Title

      Oncogene

      Volume: 30 Pages: 97-105

    • DOI

      DOI:10.1038/onc.2010.383

    • Peer Reviewed
  • [Journal Article] p73-binding partners and their functional significance2010

    • Author(s)
      Ozaki T, Kubo N, Nakagawara A
    • Journal Title

      Int. J. Proteomics

    • DOI

      DOI:10.1155/2010/283863

    • Peer Reviewed
  • [Journal Article] A novel molecular mechanism behind p53-dependent apoptosis in response to energetic stress2010

    • Author(s)
      Rintaro O, Kubo N, Kizaki H, Nakagawara A, Ozaki T
    • Journal Title

      Seikagaku

      Volume: 82 Pages: 1117-1120

    • Peer Reviewed
  • [Journal Article] Concordance for neuroblastoma in monozygotic twins : Case report and review of the literature2010

    • Author(s)
      Tajiri T, Souzaki R, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Hara T, Kohashi K, Oda Y, Masumoto K, Ohira M, Nakagawara A, Taguchi T
    • Journal Title

      J. Pediatr, Surg

      Volume: 45 Pages: 2312-2316

    • URL

      http://dx.doi.org/10.1016/j.jpedsurg.2010.08.025

    • Peer Reviewed
  • [Journal Article] Reevaluation of trkA expression as a biological marker of neuroblastoma by high-sensitivity expression analysis-a study of 106 primary neuroblastomas treated in a single institute2010

    • Author(s)
      Hishiki T, Saito T, Terui K, Sato Y, Takenouchi A, Yahata E, Ono S, Nakagawara A, Kamijo T, Nakamura Y, Matsunaga T, Yoshida H
    • Journal Title

      JP ediatr Surg

      Volume: 45 Pages: 2293-2298

    • URL

      http://dx.doi.org/10.1016/j.jpedsurg.2010.08.021

    • Peer Reviewed
  • [Journal Article] MDM2 promotes the proteasomal degradation of p73 through the interaction with Itch in HeLa cells2010

    • Author(s)
      Kubo N, Okoshi R, Nakashima K, Shimozato O, Nakagawara A, Ozaki T
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 403 Pages: 405-411

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2010.11.043

    • Peer Reviewed
  • [Journal Article] Global genomic and RNA profiles for novel risk stratification of neuroblastoma2010

    • Author(s)
      Ohira M, Nakagawara A
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 2295-2301

    • DOI

      DOI:10.1111/j.1349-7006.2010.01681.x

    • Peer Reviewed
  • [Journal Article] Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification2010

    • Author(s)
      De Brouwer S, De Preter K, Kumps C, Zabrocki P, Porcu M, Westerhout EM, Lakeman A, Vandesompele J, Hoebeeck J, Van Maerken T, De Paepe A, Laureys G, Schulte JH, Schramm A, Van Den Broecke C, Vermeulen J, Van Roy N, Beiske K, Renard M, Noguera R, Delattre O, Janoueix-Lerosey I, Kogner P, Martinsson T, Nakagawara A, Ohira M, Caron H, Eggert A, Cools J, Versteeg R, Speleman F
    • Journal Title

      Clin. Cancer Res

      Volume: 16 Pages: 4353-4362

    • DOI

      DOI:10.1158/1078-0432.

    • Peer Reviewed
  • [Journal Article] HDM2 impairs Noxa transcription and affects apoptotic cell death in a p53/p73-dependent manner in neuroblastoma2010

    • Author(s)
      Shi Y, Takenobu H, Kurata K, Yamaguchi Y, Yanagisawa R, Ohira M, Koike K, Nakagawara A, Jiang LL, Kamijo T
    • Journal Title

      Eur. J. Cancer

      Volume: 46 Pages: 2324-2334

    • URL

      http://dx.doi.org/10.1016/j.ejca.2010.05.026

    • Peer Reviewed
  • [Journal Article] Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma2010

    • Author(s)
      Iwata S, Takenobu H, Kageyama H, Koseki H, Ishii T, Nakazawa A, Tatezaki S, Nakagawara A, Kamijo T
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 1646-1652

    • DOI

      DOI:10.1111/j.1349-7006.2010.01586.

    • Peer Reviewed
  • [Journal Article] NFBD1/MDC1 participates in the regulation of G2/M transition in mammalian cells2010

    • Author(s)
      Bu Y, Suenaga Y, Okoshi R, Sang M, Kubo N, Song F, Nakagawara A, Ozaki T
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 397 Pages: 157-162

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2010.05.063

    • Peer Reviewed
  • [Journal Article] Genome-wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and MDM4 amplification at 1q32.1 in hepatoblastoma2010

    • Author(s)
      Arai Y, Honda S, Haruta M, Kasai F, Fujiwara Y, Ohshima J, Sasaki F, Nakagawara A, Horie H, Yamaoka H, Hiyama E, Kaneko Y
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 49 Pages: 596-609

    • DOI

      DOI:10.1002/gcc.20770

    • Peer Reviewed
  • [Journal Article] LMO3 interacts with p53 and inhibits its transcriptional activity2010

    • Author(s)
      Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 392 Pages: 252-257

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2009.12.010

    • Peer Reviewed
  • [Journal Article] RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a Co-activator for p532010

    • Author(s)
      Yamada C, Ozaki T, Ando K, Suenaga Y, Inoue K, Ito Y, Okoshi R, Kageyama H, Kimura H, Miyazaki M, Nakagawara A
    • Journal Title

      J. Biol. Chem

      Volume: 285 Pages: 16693-16703

    • DOI

      DOI:10.1074/jbc.M109.055525

    • Peer Reviewed
  • [Journal Article] Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma2010

    • Author(s)
      Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T
    • Journal Title

      Oncogene

      Volume: 29 Pages: 2681-2690

    • DOI

      DOI:10.1038/onc.2010.22

    • Peer Reviewed
  • [Journal Article] MCL-1V, a novel mouse antiapoptotic MCL-I variant, generated by RNA splicing at a non-canonical splicing pair2010

    • Author(s)
      Kojima S, Hyakutake A, Koshikawa N, Nakagawara A, Takenaga K
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 391 Pages: 492-497

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2009.11.086

    • Peer Reviewed
  • [Journal Article] Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature2010

    • Author(s)
      De Katleen P, Vermeulen J, Brors B, Delattre O, Eggert A, Fischer M, Janoueix-Lerosey I, Lavarino C, Maris JM, Mora J, Nakagawara A, Oberthuer A, Ohira M, Schleiermacher G, Schramm A, Schulte JH, Wang Q, Westermann F, Speleman F, Vandesompele J
    • Journal Title

      Clin. Cancer Res

      Volume: 16 Pages: 1532-1541

    • DOI

      DOI:10.1158/1078-0432.

    • Peer Reviewed
  • [Journal Article] TATA-binding protein(TBP)-like protein is engaged in etoposide-induced apoptosis through transcriptional activation of human TAp63 gene2009

    • Author(s)
      Suenaga Y, Ozaki T, Tanaka Y, Bu Y, Kamijo T, Tokuhisa T, Nakagawara A, Tamura T
    • Journal Title

      J. Biol. Chem

      Volume: 284 Pages: 35433-35440

    • DOI

      DOI:10.1074/jbc.M109.050047

    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of tumor suppressor p53 by cAMP-responsive element-binding protein/AMP-activated protein kinase complex in response to glucose deprivation2009

    • Author(s)
      Okoshi R, Ando K, Suenaga Y, Sang M, Kubo N, Kizaki H, Nakagawara A, Ozaki T
    • Journal Title

      Genes Cells

      Volume: 14 Pages: 1429-1440

    • DOI

      DOI:10.1111/j.1365-2443.2009.01359

    • Peer Reviewed
  • [Journal Article] Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1agene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway2009

    • Author(s)
      Koshikawa N, Hayashi J-I, Nakagawara A, Takenaga K
    • Journal Title

      J. Biol. Chem

      Volume: 284 Pages: 33185-33194

    • DOI

      DOI:10.1074/jbc.M109.054221

    • Peer Reviewed
  • [Journal Article] Dysregulation of platelet-derived growth factorβ-receptor expression byΔNp73 in neuroblastoma2009

    • Author(s)
      Wetterskog D, Moshiri A, Ozaki T, Uramoto H, Nakagawara A, Funa K
    • Journal Title

      Mol. Cancer Res

      Volume: 7 Pages: 2031-2039

    • DOI

      DOI:10.1158/1541-7786.MCR-08-0501

    • Peer Reviewed
  • [Journal Article] Positive auto-regulation of MYCN in human neuroblastoma2009

    • Author(s)
      Suenaga Y, Kaneko Y, Matsumoto D, Hossain MS, Ozaki T, Nakagawara A
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 390 Pages: 21-26

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2009.09.044

    • Peer Reviewed
  • [Journal Article] A simple PCR method for rapid genotype analysis of the TH-MYCN transgenic mouse2009

    • Author(s)
      Haraguchi S, Nakagawara A
    • Journal Title

      PLoSONE

      Volume: 4 Pages: e6902

    • DOI

      DOI:10.1371/journal.pone.0006902

    • Peer Reviewed
  • [Journal Article] Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation2009

    • Author(s)
      Sang M, Ando K, Okoshi R, Koida N, Li Y, Zhu Y, Shimozato O, Geng C, Shan B, Nakagawara A, Ozaki T
    • Journal Title

      Genes Cells

      Volume: 14 Pages: 775-788

    • DOI

      DOI:10.1111/j.1365-2443.2009.01309.x

    • Peer Reviewed
  • [Journal Article] Deregulated expression of E2F1 promotes proteolytic degradation of tumor suppressor p73 and inhibits its transcriptional activity2009

    • Author(s)
      Ozaki T, Okoshi R, Ono S, Kubo N, Nakagawara A
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 387 Pages: 143-148

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2009.06.141

    • Peer Reviewed
  • [Journal Article] Acetylation status of E2F-1 has an important role in the regulation of E2F-1-mediated transactivation of tumor suppressor p732009

    • Author(s)
      Ozaki T, Okoshi R, Sang M, Kubo N, Nakagawara A
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 386 Pages: 207-211

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2009.06.035

    • Peer Reviewed
  • [Journal Article] Plk1 regulates liver tumor cell death by phosphorylation of TAp632009

    • Author(s)
      Komatsu S, Takenobu H, Ozaki T, Ando K, Koida N, Suenaga Y, Ichikawa T, Hishiki T, Chiba T, Iwama A, Yoshida H, Ohnuma N, Nakagawara A, Kamijo T
    • Journal Title

      Oncogene

      Volume: 28 Pages: 3631-3641

    • DOI

      DOI:10.1038/onc.2009.216

    • Peer Reviewed
  • [Journal Article] Netrin-1 acts as a survival factor for aggressive neuroblastoma2009

    • Author(s)
      Delloye-Bourgeois C, Fitamant J, Paradisi A, Cappellen D, Douc-Rasy S, Raquin MA, Stupack D, Nakagawara A, Rousseau R, Combaret V, Puisieux A, Valteau-Couanet D, Benard J, Bernet A, Mehlen P
    • Journal Title

      J. Exp. Med

      Volume: 206 Pages: 833-847

    • DOI

      DOI:10.1084/jem.20082299

    • Peer Reviewed
  • [Journal Article] International consensus for neuroblastoma molecular diagnostics : Report from the international neuroblastoma risk group(INRG) biology committee2009

    • Author(s)
      Ambros PF, Ambros IM, Brodeur GM, Haber M, Khan J, Nakagawara A, Schleiermacher G, Speleman F, Spitz R, London WB, Cohn SL, Pearson ADJ, Maris JM
    • Journal Title

      Br. J. Cancer

      Volume: 100 Pages: 1471-1482

    • DOI

      DOI:10.1038/sj.bjc.6605014

    • Peer Reviewed
  • [Journal Article] Distinct role of ShcC docking protein in the differentiation of neuroblastoma2009

    • Author(s)
      Miyake I, Ohira M, Nakagawara A, Sakai R
    • Journal Title

      Oncogene

      Volume: 28 Pages: 662-673

    • DOI

      DOI:10.1038/onc.2008.413

    • Peer Reviewed
  • [Journal Article] High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma2009

    • Author(s)
      Yu M, Ohira M, Li Y, Niizuma H, Oo ML, Zhu Y, Ozaki T, Isogai E, Nakamura Y, Koda T, Oba S, Yu B, Nakagawara A
    • Journal Title

      Int. J. Oncol

      Volume: 34 Pages: 931-938

    • DOI

      DOI:10.3892/ijo_00000219

    • Peer Reviewed
  • [Journal Article] Clinicopathological relevance of UbcH10 in breast cancer2009

    • Author(s)
      Fujita T, Ikeda H, Kawasaki K, Taira N, Ogasawara Y, Nakagawara A, Doihara H
    • Journal Title

      Cancer Sci

      Volume: 100 Pages: 238-248

URL: 

Published: 2013-07-31  

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