Development and the safety test of next-generation self and balloon expandable drugs eluting stent

2012 Fiscal Year Final Research Report

• Project/Area Number: 21390337
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: ISHIBASHI Tadashi 東北大学, 大学院・医学系研究科, 教授 (40151401)
• Co-Investigator(Kenkyū-buntansha): SUTOU Yuji 東北大学, 大学院・工学研究科, 准教授 (80375196)
• Project Period (FY): 2009 – 2012
• Keywords: 画像診断学(含放射線診断学)IVR / ステント治療

Research Abstract

Fundamental research of the next-generation stent was done. The treatment method of intimal hyperplasia in the amputation stump section was examined. The procedure of changing the form of an end piece, the method of changing the Nitinol pipe thickness, the procedure of carrying out polishing strong only against the limb section, the method of changing the memory by heat treatment, etc. were proposed. Using niobium as stent material cannot perform a safety test in the living body, but the identification of itis impossible at present. Furthermore, the metal material and the treatment procedure of having taken safety into consideration are under examination.

Research Products

• [Journal Article] Ti-Ni-Nb合金製ステントの力学的および電気化学的特性 (2012)
  • Author(s): 高木隆光、森田真史、須藤祐司、鈴木正夫、貝沼亮介、山内清
  • Journal Title: 材料の科学と工学 Volume: 49(3) Pages: 139-143
  • URL: http://www.mssj.gr.jp/zk.htm
  • Peer Reviewed
• [Journal Article] Effect of Nitrogen Content on the Microstructure and Mechanical Properties of Ti-Mo-N Coating Films (2011)
  • Author(s): S. Komiyama, Y. Sutou and J. Koike
  • Journal Title: Metallurgical and Materials Transactions Volume: 42A(11) Pages: 3310-3315
  • DOI: doi:10.1007/s11661-010-0522-x
  • Peer Reviewed
• [Journal Article] Difficult-to-control hypertension due to bilateral aldosterone-producing adrenocortical microadenomas associated with a cortisol-producing adrenal adenoma. J Hum (2011)
  • Author(s): Morimoto R, Kudo M, Murakami O, Takase K, Ishidoya S, Nakamura Y, Ishibashi T, Takahashi S, Arai Y, Suzuki T, Sasano H, Satoh F.
  • Journal Title: Hypertens Volume: 25(2) Pages: 114-121
  • DOI: DOI:10.1038/jhh.2010.35
  • Peer Reviewed
• [Journal Article] The fatal risk in hepatic artery embolization for hemostasisafter pancreatic and hepatic surgery: importance of collateral arterial pathways (2011)
  • Author(s): Sato A, Yamada T, Takase K, Matsuhashi T, Higano S, Kaneda T, Egawa S, Takeda K, Ishibashi T, Takahashi S.
  • Journal Title: J Vasc Interv Radiol Volume: 22(3) Pages: 287-293
  • DOI: doi:10.1016/j.jvir.2010.11.023
  • Peer Reviewed
• [Journal Article] Single-center Outcome of Laparoscopic Unilateral Adrenalectomy for Patients With Primary Aldosteronism: Lateralizing Disease Using Results of Adrenal Venous Sampling (2010)
  • Author(s): Ishidoya S, Kaiho Y, Ito A, Morimoto R, Satoh F, Ito S, Ishibashi T, Nakamura Y, Sasano H, Arai Y.
  • Journal Title: Urology Volume: 78(1) Pages: 68-73
  • DOI: doi:10.1016/j.urology.2010.12.042
  • Peer Reviewed
• [Journal Article] Radiation dose and radiationprotection for patients and physicians during interventional procedure (2010)
  • Author(s): Chida K, Kato M, Kagaya Y, Zuguchi M, Saito H, Ishibashi T, Takahashi S, Yamada S, Takai, Y.
  • Journal Title: J Radiat Res Volume: 51(2) Pages: 97-105
  • DOI: DOI:org/10.1269/jrr.09112
  • Peer Reviewed
• [Journal Article] Effect of Heat Treatment on the Hardness of Ti-Mo-N Films Deposited by RF Reactive Magnetron Sputtering (2010)
  • Author(s): S. Komiyama, Y. Sutou and J. Koike
  • Journal Title: Materials Transactions Volume: 51(8) Pages: 1467-1473
  • DOI: doi:10.2320/matertrans.M2010119
  • Peer Reviewed
• [Journal Article] Optimizing patient radiation dose in intervention procedure (2010)
  • Author(s): Chida K, Kato M, Saito H, Ishibashi T, Takahashi S, Kohzuki M, Zuguchi M.
  • Journal Title: Acta Radiol Volume: 51(1) Pages: 33-39
  • DOI: doi:10.3109/02841850903229141
  • Peer Reviewed
• [Journal Article] Effects of ageing on bainiticand thermally induced martensitic transformations in ductile Cu-Al-Mn-based shape memory alloys (2009)
  • Author(s): Y. Sutou, N. Koeda, T. Omori, R. Kainuma,K. Ishida
  • Journal Title: Acta Materialia Volume: 57 (19) Pages: 5748-5758
  • DOI: doi:org/10.1016/j.actamat.2009.08.003
  • Peer Reviewed
• [Journal Article] Effects of aging on stress-induced martensitic transformation in ductile Cu-Al-Mn-based shape memory alloys (2009)
  • Author(s): Y. Sutou, N. Koeda, T. Omori, R. Kainuma, K. Ishida
  • Journal Title: Acta Materialia Volume: 57 (19) Pages: 5759-5770
  • DOI: doi:org/10.1016/j.actamat.2009.08.011
  • Peer Reviewed
• [Journal Article] Elastic and Superelastic Properties of NiFeCoGa Fibers Grown by Micro-Pulling-Down Method (2009)
  • Author(s): K. Oikawa, R. Saito, K. Anzai, H. Ishikawa, Y. Sutou, T. Omori, A. Yoshikawa, VA. Chernenko, S. Besseghini, A.Gambardella, R. Kainuma, K. Ishida
  • Journal Title: Materials Transactions Volume: 50(4) Pages: 934-937
  • DOI: doi:10.2320/matertrans.M2009013
  • Peer Reviewed
• [Journal Article] Evaluation of Self-Expandable, FK506-Coated, Covered Stents in Carine Animal Model (2009)
  • Author(s): S.Sato, Y.Nakayama, T.Matsuhashi, K.Seiji, K.Matsunaga, C.Takazawa, T.Ishibashi, Y.Zhou, H.Ishibashi-Ueda, Y.Okamoto, H.Asano, S.Takahashi
  • Journal Title: J Biomed Mater Res B Appl Biomater Pages: 647-652
  • DOI: doi:10.1002/jbm.b.31330
  • Peer Reviewed
• [Journal Article] Treatment of In-Stent Restenosis with Beraprost Sodium: An Experimental Study of Short- And Intermediate-Term Effects in Dogs (2009)
  • Author(s): Seiji K, Tsuda M, Matsuhashi T, Takase K, Miyachi H, Yamada T, Ishibashi T, Higano S, Takahashi S.
  • Journal Title: Clin Exp Pharmacol Physiol Volume: 36(12) Pages: 1164-1169
  • DOI: doi:10.1111/j.1440-1681.2009.05209.x
  • Peer Reviewed
• [Journal Article] Evaluation of patient radiation dose during cardiac interventional procedures: what is the most effective method? (2009)
  • Author(s): Chida K, Kagaya Y, Saito H, Ishibashi T, Takahashi S, Zuguchi M.
  • Journal Title: Acta Radiol Volume: 50(5) Pages: 474-481
  • DOI: doi:10.3109/02841850903229141
  • Peer Reviewed
• [Journal Article] Radiation dose of interventional radiology system using a flat-panel detector (2009)
  • Author(s): Chida K, Inaba Y, Saito H, Ishibashi T, Takahashi S, Kohzuki M, Zuguchi M.
  • Journal Title: AJR Am J Roentgenol Volume: 193(6) Pages: 1680-1685
  • DOI: doi:10.2214/AJR.09.2747
  • Peer Reviewed
• [Presentation] 医療用形状記憶合金ワイヤーの生体適合性 (2011)
  • Author(s): 高木隆光三木将仁森田真史須藤祐司鈴木正夫古川明久貝沼亮介山内清
  • Organizer: 第148回日本金属学会春期大会
  • Place of Presentation: 東京
  • Year and Date: 20110325-20110327
• [Presentation] Retreval of a ruptured pacemaker lead severely fixed in the right ventricle Cardiovascular Interventional Society in Europe (2010)
  • Author(s): A. Sato, T. Ishibashi, et al
  • Place of Presentation: Valencia, Spain
  • Year and Date: 20101002-20101006
• [Presentation] Balloon-occluded retrograde transvenous obliteration of high flow arteriovenous malformation: repeated injection method with ethanolamine oleate (2009)
  • Author(s): A.Sato, H.Rikimaru, K.Majima, T.Ishibashi
  • Organizer: CIRSE
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 20090919-20090923
• [Presentation] Ductile Cu-Al-Mn-based shape memory alloys (2009)
  • Author(s): Y. Sutou, T. Omori, R. Kainuma, K. Ishida, K. Yamauchi
  • Organizer: Thermec 09
  • Place of Presentation: ベルリ ン、ドイツ(招待講演)
  • Year and Date: 20090824-20090828
• [Book] 知らなかった技術のすべてー文光堂 (2013)
  • Author(s): 石橋忠司, ほか
  • Total Pages: 194-207,298
  • Publisher: 考えるCT撮影技術-知ってるつもりで
• [Book] 腎臓リハビリテーション (2012)
  • Author(s): 上月正博編著、石橋忠司, ほか
  • Total Pages: 84-86,491
  • Publisher: 医歯薬出版株式会社
• [Book] コメディカルのための疾患・画像ファイル (2010)
  • Author(s): 鈴木正行、石橋忠司, ほか
  • Total Pages: 224-245,288
  • Publisher: 文光堂