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2011 Fiscal Year Final Research Report

A translational research for promotion of multimodality therapy combined with proton beam therapy

Research Project

  • PDF
Project/Area Number 21390338
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionUniversity of Tsukuba

Principal Investigator

SAKURAI Hideyuki  筑波大学, 医学医療系, 教授 (50235222)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Hideki  福井大学, 高エネルぎ-医学研究センター, 准教授 (40142377)
OHNO Tatsuya  群馬大学, 重粒子医学研究センター, 准教授 (10344061)
MORITAKE Takashi  筑波大学, 医学医療系, 講師 (50450432)
MIZUMOTO Masashi  筑波大学, 医学医療系, 講師 (20512388)
OKUMURA Toshiyuki  筑波大学, 医学医療系, 准教授 (50241815)
HASHIMOTO Takayuki  筑波大学, 医学医療系, 講師 (60400678)
Project Period (FY) 2009 – 2011
Keywords陽子線治療 / 集学的治療 / 化学放射線療法 / 抗腫瘍効果 / 併用療法
Research Abstract

The aim of this study is to promote translational research for multimodality therapy combined with proton beam therapy (PBT). We found increasing radiobiological effect on late phase of bragg peak, and also detected apoptosis in the crypt cells irradiated with very low dose of proton. For normal tissue reaction, dose-volume relationship was clearly found both in rib fracture on PBT for liver cancer and in pneumonistis on PBT combined with chemotherapy for advanced lung cancer. Finally, from these translational researches, we have started clinical trials for advanced lung cancer and pediatric cancer as a multimodality therapy combined with PBT.

  • Research Products

    (55 results)

All 2012 2011 2010 2009 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (34 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Prospective multi-institutional study of definitive radiotherapy with high-dose-rate intracavitary brachytherapy in patients with nonbulky (<4-cm) stage I and II uterine cervical cancer (JAROG0401/JROSG04-2).2012

    • Author(s)
      Toita T, Kato S, 他18名
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 82(1) Pages: e49-56

    • DOI

      DOI:10.1016/j.ijrobp.2011.01.022

    • Peer Reviewed
  • [Journal Article] Influence of secondary neutrons induced by proton radiotherapy for cancer patients with implantable cardioverter defibrillators.2012

    • Author(s)
      Hashimoto T, Isobe T, 他8名
    • Journal Title

      Radiat Oncol

      Volume: 7 Pages: 10

    • DOI

      DOI:10.1186/1748-717X-7-10

    • Peer Reviewed
  • [Journal Article] Results of Proton Beam Therapy without Concurrent Chemotherapy for Patients with Unresectable Stage III Non-small Cell Lung Cancer2012

    • Author(s)
      Oshiro Y, Mizumoto M, 他10名
    • Journal Title

      J Thorac Oncol

      Volume: 7 Pages: 370-375

    • DOI

      DOI:10.1097/JTO.0b013e31823c485f

    • Peer Reviewed
  • [Journal Article] Evaluation of liver function after proton beam therapy for hepatocellular carcinoma2012

    • Author(s)
      Mizumoto M, Okumura T, 他15名
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 82 Pages: e529-535

    • DOI

      DOI:S0360-3016(11)02803-3[pii]10.1016/j.ijrobp.2011.05.056

    • Peer Reviewed
  • [Journal Article] Proton beam therapy for hepatocellular carcinoma located adjacent to the alimentary tract.2012

    • Author(s)
      Nakayama H, Sugahara S, 他7名
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 80 Pages: 992-995

    • DOI

      DOI:S0360-3016(10)00420-7[pii]10.1016/j.ijrobp.2010.03.015

    • Peer Reviewed
  • [Journal Article] Proton Beam Therapy of Stage II and III NonSmall-Cell Lung Cancer.2011

    • Author(s)
      Nakayama H, Satoh H, 他6名
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 81 Pages: 979-984

    • DOI

      DOI:S0360-3016(10)00873-4[pii]10.1016/j.ijrobp.2010.06.024

    • Peer Reviewed
  • [Journal Article] Hyperfractionated Concomitant Boost Proton Beam Therapy for Esophageal Carcinoma.2011

    • Author(s)
      Mizumoto M, Sugahara S, 他8名
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 81 Pages: e601-606

    • DOI

      DOI:S0360-3016(11)00361-0[pii]10.1016/j.ijrobp.2011.02.041

    • Peer Reviewed
  • [Journal Article] Proton Beam Therapy for Hepatocellular Carcinoma: A Comparison of Three Treatment Protocols.2011

    • Author(s)
      Mizumoto M, Okumura T, 他15名
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 81 Pages: 1039-1045

    • DOI

      DOI:S0360-3016(10)00943-0[pii]10.1016/j.ijrobp.2010.07.015

    • Peer Reviewed
  • [Journal Article] Nitric oxide is a key molecule serving as a bridge between radiationinduced bystander and adaptive responses2011

    • Author(s)
      Matsumoto H, Tomita M, Otsuka K, Hatashita M, Hamada N
    • Journal Title

      Curr.Mol.Pharmacol

      Volume: 4 Pages: 126-134

    • DOI

      DOI:10.2174/1874467211104020126

    • Peer Reviewed
  • [Journal Article] Costeffactiveness of carbon ion radiation therapy for locally recurrent rectal cancer2010

    • Author(s)
      Mobaraki A, Ohno T, 他3名
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 1834-1839

    • DOI

      DOI:10.1111/j.1349-7006.2010.01604.x

    • Peer Reviewed
  • [Journal Article] Phase I/II trial of hyperfractionated concomitant boost proton radiotherapy for supratentorial glioblastoma multiforme2010

    • Author(s)
      Mizumoto M, Tsuboi K, 他12名
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 77 Pages: 98-105

    • DOI

      DOI:S0360-3016(09)00653-1[pii]10.1016/j.ijrobp.2009.04.054

    • Peer Reviewed
  • [Journal Article] Clinical results of proton-beam therapy for locoregionally advanced esophageal cancer.2010

    • Author(s)
      Mizumoto M, Sugahara S, 他8名
    • Journal Title

      Strahlenther Onkol

      Volume: 186 Pages: 482-488

    • DOI

      DOI:10.1007/s00066-010-2079-4

    • Peer Reviewed
  • [Journal Article] Multi-institutional phase II clinical study of concurrent chemoradiotherapy for locally advanced cervical cancer in east and southeast Asia.2010

    • Author(s)
      Kato S, Ohno T, Thephamongkhol K, Chansilpa Y, Yuxing Y, Devi CR, Bustam AZ, Calaguas MJ, de Los Reyes RH, Cho CK, Dung TA, Supriana N, Mizuno H, Nakano T, Tsujii H
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 77 Pages: 751-757

    • DOI

      DOI:10.1016/j.ijrobp.2009.06.011

    • Peer Reviewed
  • [Journal Article] Proton beam therapy for hepatocellular carcinoma: the University of Tsukuba experience2009

    • Author(s)
      Nakayama H, Sugahara S, 他8名
    • Journal Title

      Cancer

      Volume: 115 Pages: 5499-5506

    • DOI

      DOI:10.1002/cncr.24619

    • Peer Reviewed
  • [Journal Article] Outcome of T4 (International Union Against Cancer Staging System, 7th edition) or Recurrent Nasal Cavity and Paranasal Sinus Carcinoma Treated with Proton Beam

    • Author(s)
      Fukumitsu N, Okumura T, 他12名
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: (in press)

    • DOI

      DOI:10.1016/j.ijrobp.2011.07.032

    • Peer Reviewed
  • [Journal Article] Verification of beam delivery using fibrosis after proton beam irradiation to the lung tumor.

    • Author(s)
      Fukumitsu N, Oshiro Y, 他7名
    • Journal Title

      Lung Cancer

      Volume: (in press)

    • DOI

      DOI:S0169-5002(12)00017-7[pii]10.1016/j.lungcan.2012.01.007

    • Peer Reviewed
  • [Presentation] Roles and problems of proton beam radiation therapy for the treatment of pediatric cancer.2012

    • Author(s)
      Sakurai H, et al
    • Organizer
      Second International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
    • Place of Presentation
      Kyoto
    • Year and Date
      20120216-17
  • [Presentation] Proton beam therapy at PMRC in University of Tsukuba2012

    • Author(s)
      Sakurai H
    • Organizer
      Workshop"Modern Particle Therapy"
    • Place of Presentation
      Essen,Germany
    • Year and Date
      2012-02-28
  • [Presentation] Results of proton beams radiotherapy without concurrent chemotherapy for patients with unresectable stage III non-small cell lung cancer2011

    • Author(s)
      Oshiro Y, et al
    • Organizer
      ASTRO 53 Annual Meeting
    • Place of Presentation
      Philadlphia,USA
    • Year and Date
      20111002-06
  • [Presentation] Proton beam therapy for metastatic liver cancer2011

    • Author(s)
      Hashimoto T, et al
    • Organizer
      ASTRO 53 Annual Meeting
    • Place of Presentation
      Miami,USA
    • Year and Date
      20111002-06
  • [Presentation] Nitric oxide is a key molecule serving as a bridge between radiation-induced bystander and adaptive responses.2011

    • Author(s)
      Matsumoto H, et al
    • Organizer
      The 14th International Congress of Radiation Research
    • Place of Presentation
      Warsaw,Poland
    • Year and Date
      20110828-0901
  • [Presentation] Proton beam therapy for patient with liver metastasis from breast carcinoma.2011

    • Author(s)
      Kanemoto A, et al
    • Organizer
      PTCOG 50
    • Place of Presentation
      Phladelphia,USA
    • Year and Date
      20110508-14
  • [Presentation] A role of radiosurgery for functional preservation: from personal experiences of 4500 patients treated with microsurgery, Gamma Knife and Cyberknife radiosurgery.2011

    • Author(s)
      Inoue H,et al
    • Organizer
      10th Biennial Congress and Exhibition of the ISRS
    • Place of Presentation
      Paris,France
    • Year and Date
      20110508-12
  • [Presentation] Considerable difficulty in rcts with proton beamtherapy -which cancer status is appropriate?-2011

    • Author(s)
      Sakurai H
    • Organizer
      ESTRO Anniversary/ Radiotherapy & Oncology
    • Place of Presentation
      London, UK
    • Year and Date
      20110508-12
  • [Presentation] Proton beam therapy at University of Tsukuba.2011

    • Author(s)
      Sakurai H, et al
    • Organizer
      First Inernational Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
    • Place of Presentation
      Kyoto,Japan
    • Year and Date
      20110203-04
  • [Presentation] Cost effectiveness of carbon ion radiotherapy: comparison with other treatments2011

    • Author(s)
      Ohno T, et al
    • Organizer
      10th Heavy Ion Charged Particle Therapy Symposium/International Symposium on Heavy Ion Radiotherapy and Advanced Technology
    • Place of Presentation
      Tokyo,Japan
    • Year and Date
      20110112-13
  • [Presentation] Efficacy and limitation of radiation therapy for hepatocellular carcinoma complicated with liver cirrhosis.2011

    • Author(s)
      Abei M, et al
    • Organizer
      2nd AsiaPacific Primary Liver Cancer Expert Meeting. Workshop "Radiotherapy of HCC"
    • Place of Presentation
      Osaka,Japan
    • Year and Date
      2011-07-03
  • [Presentation] Influence of Neutron Generated in 10 MV-X-ray Irradiation and Proton Beam on Implatable Cardioverter Defibrillators (ICDs).2010

    • Author(s)
      Isobe T, et al
    • Organizer
      Chicago,USA
    • Place of Presentation
      (RSNA)96th Scientific Assembly and Annual Meeting
    • Year and Date
      20101128-1203
  • [Presentation] Influence of particle therapy on implantable cardiac devices:An experimental study.2010

    • Author(s)
      Hashimoto T, et al
    • Organizer
      ASTRO 52nd Annual Meeting
    • Place of Presentation
      San Diego,USA
    • Year and Date
      20101031-1104
  • [Presentation] Proton beam therapy for intrahepatic cholangio carcinoma2010

    • Author(s)
      Ohkawa A, et al
    • Organizer
      ASTRO 52nd Annual Meeting
    • Place of Presentation
      San Diego,USA
    • Year and Date
      20101031-1104
  • [Presentation] Influence of high-energy photon beam irradiation on implantable cardioverter -defibrillators (ICDs)- experimental comparison of two present- day models2010

    • Author(s)
      Hashii H, et al
    • Organizer
      ASTRO 52nd Annual Meeting
    • Place of Presentation
      San Diego,USA
    • Year and Date
      20101031-1104
  • [Presentation] Radioadaptiveresponse can be induced even after priming irradiation of a limited number of cells with charged heavy particles.2010

    • Author(s)
      Matsumoto H, et al
    • Organizer
      The 56th Annual Meeting of Radiation Research Society
    • Place of Presentation
      Maui,Hawaii,USA
    • Year and Date
      20100925-29
  • [Presentation] Radiation-induced rib fracture after hypofractionated proton beam therapy for hepatocellular carcinoma2010

    • Author(s)
      Kanemoto A, et al
    • Organizer
      ESTRO 29
    • Place of Presentation
      Barcelona,Spain
    • Year and Date
      20100912-16
  • [Presentation] A redox status of tumor microenvironment in cancer therapy2010

    • Author(s)
      Matsumoto H
    • Organizer
      5th(ACHO) The 27th(JCTM)
    • Place of Presentation
      Fukuoka
    • Year and Date
      20100910-11
  • [Presentation] Carbon ion radiotherapy at Gunma University2010

    • Author(s)
      Ohno T, et al
    • Organizer
      The 4th Japanese- European Joint Symposium on Ion Cancer Therapy
    • Place of Presentation
      Stockholm,Sweden
    • Year and Date
      20100909-11
  • [Presentation] Carbon ion radiotherapy at Gunma University: Currently indicated cancer and estimation of need2010

    • Author(s)
      Ohno T, et al
    • Organizer
      CAARI 2010
    • Place of Presentation
      Texas,USA
    • Year and Date
      20100805-10
  • [Presentation] Influence of particle therapy on cardiac implantable devices -An experimental study -2010

    • Author(s)
      Hashimoto T, et al
    • Organizer
      PTCOG 49
    • Place of Presentation
      Maebashi,Gunma
    • Year and Date
      20100520-22
  • [Presentation] Carbon ion radiotherapy project at Gunma University.2010

    • Author(s)
      Ohno T
    • Organizer
      PTCOG 49
    • Place of Presentation
      Maebashi,Gunma
    • Year and Date
      20100520-22
  • [Presentation] Proton beam radiotherapy for skull base chordoma/chondrosarcoma in Tsukuba2010

    • Author(s)
      Tsuboi K, et al
    • Organizer
      PTCOG 49
    • Place of Presentation
      Maebashi,Gunma
    • Year and Date
      20100520-22
  • [Presentation] Development of multiple regions tracking system to reduce inter and intra-fractional error for proton therapy.2010

    • Author(s)
      Terunuma T, et al
    • Organizer
      PTCOG 49
    • Place of Presentation
      Maebashi,Gunma
    • Year and Date
      20100520-22
  • [Presentation] Proton beam therapy for hepatocellular carcinoma. In: Datta N, Choudhury P, editors2010

    • Author(s)
      Sakurai H, et al
    • Organizer
      IX Annual International Cancer Conference (RGCON-2010)
    • Place of Presentation
      Delhi,India
    • Year and Date
      20100326-28
  • [Presentation] Proton and heaby ion therapy. In: Datta N, Choudhury P, editors.2010

    • Author(s)
      Sakurai H, et al
    • Organizer
      IX Annual International Cancer Conference (RGCON-2010)
    • Place of Presentation
      Delhi,India
    • Year and Date
      20100326-28
  • [Presentation] Proton beam therapy at PMRC, University of Tsukuba -present and future2010

    • Author(s)
      Sakurai H, et al
    • Organizer
      Scientific Meeting, PTCOG 49
    • Place of Presentation
      Maebashi,Gunma
    • Year and Date
      2010-05-20
  • [Presentation] A phase I/II clinical trial of hyperfractionated concomitant boost proton radiotherapy forsupratentorial glioblastoma multiforme2009

    • Author(s)
      Tsuboi K, et al
    • Organizer
      ASTRO 51 Annual Meeting
    • Place of Presentation
      Chicago,USA
    • Year and Date
      20091101-05
  • [Presentation] The use of image analysis software system to evaluate the geometrical accuracy of proton beam irradiation in the liver2009

    • Author(s)
      Fukumitsu N, et al
    • Organizer
      ASTRO 51 Annual Meeting
    • Place of Presentation
      Chicago,USA
    • Year and Date
      20091101-05
  • [Presentation] A new paradigm in radioadaptive response developing from microbeam researches.2009

    • Author(s)
      Matsumoto H, et al
    • Organizer
      International Workshop on Radiation Biology and Radiation Protection
    • Place of Presentation
      Shanghai,China
    • Year and Date
      20091014-16
  • [Presentation] Hyperfractionated concomitant boost proton radiotherapy for supratentorial glioblastoma multiforme2009

    • Author(s)
      Tsuboi K, et al
    • Organizer
      PTCOG 48
    • Place of Presentation
      Heidelberg,Germany
    • Year and Date
      20090928-1003
  • [Presentation] Prototype of real-time tumor-tracking system without implanted fiducial marker for proton therapy2009

    • Author(s)
      Terunuma T, et al
    • Organizer
      PTCOG 48
    • Place of Presentation
      Heidelberg,Germany
    • Year and Date
      20090928-1003
  • [Presentation] Thermosensitization and heat-induced apoptosis by parthenolide, NF-κB inhibitor, in human lung cancer A549 cells2009

    • Author(s)
      Hayashi S, et al
    • Organizer
      The 25th Annual Meeting of the European Society for Hyperthermic Oncology
    • Place of Presentation
      Verona,Italy
    • Year and Date
      20090604-06
  • [Presentation] Multisession cyberknife radiosurgery for large brain metastases: The 14Gy-volumes and isonecrosis risk lines to avoid radiation necrosis.2009

    • Author(s)
      Inoue KH, et al
    • Organizer
      9th (ISRS)
    • Place of Presentation
      Seoul,Korea
    • Year and Date
      2009-06-07
  • [Book] Proton therapy for thoracoabdominal tumors. Ute Linz ed. Ion Beam Therapy. 1st edition2011

    • Author(s)
      Sakurai H, Okumura T, Sugahara S, Nakayama H, Tokuuye K
    • Total Pages
      207-222
    • Publisher
      Berlin Heidelberg,Germany: Springer-Verlag
  • [Book] Ion Beam Therapy for Gynecological Tumors. Ute Linz ed. Ion Beam Therapy.2011

    • Author(s)
      Ohno T, Kato S
    • Total Pages
      237-251
    • Publisher
      Berlin Heidelberg,Germany: Springer-Verlag
  • [Remarks]

    • URL

      http://www.pmrc.tsukuba.ac.jp/

  • [Remarks]

    • URL

      http://www3.pmrc.tsukuba.ac.jp/

  • [Patent(Industrial Property Rights)] 放射線障害防護剤2010

    • Inventor(s)
      松本英樹
    • Industrial Property Rights Holder
      福井大学
    • Industrial Property Number
      2010-079150
    • Filing Date
      2010-03-30

URL: 

Published: 2014-08-29  

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