Development of amyloid^<13> C-MR imaging of the brain at 7T

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390349
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: HIRAI Toshinori 熊本大学, 大学院・生命科学研究部, 准教授 (40274724)
• Co-Investigator(Kenkyū-buntansha): IRIGUCHI Norio 熊本大学, 総合情報基盤センター, 教授 (00347006) ; KUNIYASU Akihiko 崇城大学, 薬学部, 教授 (90241348) ; IKEDA Tsuyoshi 崇城大学, 薬学部, 教授 (80295138) ; YAMAGATA Kazuya 熊本大学, 大学院・生命科学研究部, 教授 (70324770) ; TERASAWA Hiroaki 熊本大学, 大学院・生命科学研究部, 教授 (10300956) ; SAKASHITA Naomi 熊本大学, 大学院・生命科学研究部, 准教授 (90284752) ; KOMOHARA Yoshihiro 熊本大学, 大学院・生命科学研究部, 講師 (40449921)
• Co-Investigator(Renkei-kenkyūsha): ARAKI Norie 熊本大学, 大学院・生命科学研究部, 准教授 (80253722)
• Project Period (FY): 2009 – 2011
• Keywords: 脳・神経 / 認知症 / 神経科学 / MRI

Research Abstract

The purpose of this study was to explore the feasibility of carbon-13(^<13> C) magnetic resonance imaging(^<13> C-MRI) to depict^<13> C-labeled amyloid-binding materials in model mice for Alzheimer dementia at 7T. Although we succeeded in producing^<13> C-labeled amyloid-binding materials, water solubility of the materials was low. We tried to solve the materials. After administration of the materials to the model mice, C-13 MR imaging of the brain was performed. Although the area of high signal in the brain was observed, there were some discrepancies between the MR and histopathologic findings. Further investigation is needed to clarify the feasibility of^<13> C-MRI.