2011 Fiscal Year Final Research Report
Study of the correlation between disseminated cancer cells and host factors in establishment of recurrence and metastasis of hepatocellular carcinoma
| Project/Area Number |
21390369
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
KAMIYAMA Toshiya 北海道大学, 大学院・医学研究科, 准教授 (80322816)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Kazuaki 北海道大学, 大学院・医学研究科, 特任助教 (80374338)
YOKOO Hideki 北海道大学, 北海道大学病院, 医員 (70399947)
TAHARA Munenori 北海道大学, 北海道大学病院, 医員 (30306576)
TODO Satoru 北海道大学, 大学院・医学研究科, 特任教授 (60136463)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 遊離癌細胞 / 癌幹細胞 / CD133 / 肝細胞癌 / 大腸癌 / AFPmRNA / VEGFR1mRNA |
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| Research Abstract |
Cytoplasmic expression of CD133 in HCC is associated with elevated serum AFP level, histologically high-grade tumor, and tumor invasion to the major branch of the portal vein. Positive cytoplasmic expression of CD133 represented the risk of poor prognosis. CD133 overexpression was an independent prognostic factor for PS of colorectal cancer (CRC) patients. Evaluation of the frequency and pattern of CD133 expression is useful for predicting prognosis, recurrence, and chemosensitivity in CRC patients. We found a significant tendency for patients who were positive for BM-AFP mRNA to experience recurrence within 1 year after surgery compared to those negative for BM-AFP mRNA. The BM-VEGFR-1 mRNA level of all HCC patients was higher than that of normal controls and the PH-VEGFR-1 mRNA level of almost all patients was higher that of normal controls. The classification by BM-VEGFR-1 mRNA/BM-AFP mRNA was a significant risk factor for recurrence within 1 year after surgery. The importance of the coexistence of disseminated cancer cells and VEGFR-1-positive hematopoietic bone marrow progenitor cells was also proved because the DFS curve of patients negative for BM-AFP mRNA and BM-VEGFR-1 mRNA ; low was better in the other 3 groups. The evaluation of BM-AFP and BM-VEGFR-1 mRNA in patients with HCC may be a valuable predictor of disease recurrence following curative resection.
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[Journal Article] Co-expression of Mesothelin and CA125 Correlates with Unfavorable Patient Outcome in Pancreatic Ductal Adenocarcinoma2011
Author(s)
Einama T, Kamachi H, Nishihara H, Homma S, Kanno H, Takahashi K, Sasaki A, Tahara M, Okada K, Muraoka S, Kamiyama T, matsuno Y, Ozaki M, Todo S
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Journal Title
Pancreas
Volume: 40(8)
Pages: 1276-82
DOI
Peer Reviewed
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[Journal Article] Relationship Between Diffusion-Weighted Magnetic Resonance Imaging and Histolog ical Tumor Grading of Hepatocellular Carcinoma2011
Author(s)
Nakanishi M, Chuma M, Hige S, Omatsu T, Yokoo H, Nakanishi K, Kamiyama T, Kubota K, Haga H, Matsuno Y, Onodera Y, Kato M, Asaka M
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Journal Title
Ann Surg Oncol
Volume: 17
DOI
Peer Reviewed
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[Journal Article] The influence of hepatitis B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma2009
Author(s)
Chuma M, Hige S, Kamiyama T, Meguro T, Nagasaka A, Nakanishi K, Yamamoto Y, Nakanishi M, Kohara T, Sho T, Yamamoto K, Horimoto H, Kobayashi T, Yokoo H, Matsushita M, Todo S, Asaka M
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Journal Title
J Gastroenterol
Volume: 44(9)
Pages: 991-9
DOI
Peer Reviewed
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[Presentation] 発現頻度・発現パターンから見た大腸癌における癌幹細胞マーカーCD133の臨床的意義についての検討2010
Author(s)
高橋周作,神山俊哉,島田信吾,工藤岳秋,廣瀬邦弘,佐治裕,崎浜秀康,尾崎倫孝,外丸詩野,石津明洋,藤堂省
Organizer
日本外科学会
Place of Presentation
名古屋国際会議場
Year and Date
20100300
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