2011 Fiscal Year Final Research Report
Development of an innovative drug targeting th e ileal mucosa to promote intestinal adaptation and to treat pouchitis
| Project/Area Number |
21390370
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 回腸嚢炎 / 潰瘍性大腸炎 / intestinal adaptation |
|---|
| Research Abstract |
Drug delivery system is defined as the method which enables to efficiently bring drugs to target tissues or cells, resulting in therapeutic effects at most and side effects at least. Poly lactic/glycolic acids are harmless and available as a drug carrier. We established the methods to evaluate distribution of drug-incorporated PLGA particles, release of drugs, and effects of drugs on target and non-target cells. Because oral administration of PLGA particles failed to be absorbed in GI mucosa, modif ication of the particle surface may be required.
|
