2011 Fiscal Year Final Research Report
General overview of research on diagnosis of pancreatic cancer using molecular makersinpancreaticjuiccandclinicalapPlicationofmolecularmakersondiagnosisofIPMNsubtype
| Project/Area Number |
21390380
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Junji 九州大学, 大学病院, 助教 (90529801)
TOMA Hroki 九州大学, 大学病院, 講師 (80437780)
SATO Norihro 九州大学, 大学院・医学研究院, 共同研究員 (20423527)
OHOHDA Denoki 九州大学, 大学院・医学研究院, 講師 (20452708)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 膵臓外科学 / 膵癌 / mRNA/microRNA / IPMN |
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| Research Abstract |
We showed that LMO2 was more frequently detected in high-grade PanIN lesions and the LMO2 messenger RNA levels were significantly higher in invasive ductal carcinoma cells. Expression of claudin-4 anSiooA4A4 mRNA is diagnostic and poor prognostic markers in PDCAMircoRNA-2l21, microRNA-li-sp5pmicroRNA-2os0MircoRNA-2l21 expression were new poor prognostic markers of PDCA. High expression omicroRNA-li-sp5pmicroRNA-2os03 modulates biological functions of pancreatic cancer cells including their proliferation, invasion and chemoresistanceMicroRNA-2ooc0c was an independent better prognostic maker in PDCA. AnmicroRNA-2l21 anmicroRNA-lss55 expression analyses in preoperative juice samples of PDCA. Expression of Reg-4 and claudin-4 were promising makers for prediction of the intestinal type in IPMN. The patients with high expression ohENT-l-1 and dCK mRNA and low expression oRRMlM1 and RRM2 and the patients with low EGFR mRNA expression were predicted for better outcome in pancreatic cancer after gemcitabine-based adjuvant chemotherapy. And high expression omicroRNA-l42-sp5p anmicroRNA-2o404 were also predictive markers for gemcitabine response after surgical resection of pancreatic cancer.
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[Journal Article] High EGFR mRNA expression is a prognostic factor for reduced survival in pancreaticcancer after gemcitabine-based adjuvant chemotherapy2011
Author(s)
Fujita H, Ohuchida K, Mizumoto K, Itaba S, Ita T, Nakata K, Yu J, Kayashima T, Hayashi A, Souzaki R, Tajiri T, Onimaru M, Manabe T, Ohtsuka T, Tanaka M.
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Journal Title
International journal of oncology
Volume: 38(3)
Pages: 629-641
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[Journal Article] Gene expression levels as predictive markers of outcome in pancreatic cancer after gemcitabine-based adjuvant chemotherapy2010
Author(s)
Fujita H, Ohuchida K, Mizumoto K, Itaba S, Ita T, Nakata K, Yu J, Kayashima T, Souzaki R, Tajiri T, Manabe T, Ohtsuka T and Tanaka M
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Journal Title
Neoplasia
Volume: 12
Pages: 807-817
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[Journal Article] LMO2 is a novel predictive marker for a better prognosis in pancreatic cancer2009
Author(s)
0 Nakata K, Ohuchida K, Nagai E, Hayashi A, Miyasaka Y, Kayashima T, Yu J, Aishima S, Oda Y, Mizumoto K, Tanaka M and Tsuneyoshi M
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Journal Title
Neoplasia
Volume: 11
Pages: 712-719
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