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2012 Fiscal Year Final Research Report

Development of hybrid therapy of myocardial regenerative medicine and ventricular assist circulation to improve prognosis of heart transplant candidate

Research Project

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Project/Area Number 21390398
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

TAKEWA Yoshiaki  独立行政法人国立循環器病研究センター, 研究所, 室長 (20332405)

Co-Investigator(Kenkyū-buntansha) TAENAKA Yoshiyuki  独立行政法人国立循環器病研究センター, 研究所, 副所長 (00142183)
TATSUMI Eisuke  独立行政法人国立循環器病研究センター, 研究所, 部長 (00216996)
Co-Investigator(Renkei-kenkyūsha) HONMA Akihiko  独立行政法人国立循環器病研究センター, 研究所, 室長 (20287428)
SUMIKURA Hirohito  独立行政法人国立循環器病研究センター, 研究所, 研究員 (20433998)
OHNUMA Kentarou  独立行政法人国立循環器病研究センター, 研究所, 研究員 (50527992)
HANADA Shigeru  独立行政法人国立循環器病研究センター, 研究所, 研究員 (90514547)
KAKUTA Yukihide  独立行政法人国立循環器病研究センター, 研究所, 研究員 (30443485)
FUJII Yutaka  独立行政法人国立循環器病研究センター, 研究所, 研究員 (20589303)
TAKAKI Miyako  奈良県立医科大学, 医学部, 教授 (00033358)
MIZUGUCHI Hiroyuki  大阪大学, 薬学研究科, 教授 (50311387)
Project Period (FY) 2009 – 2012
Keywords心臓大血管外科学
Research Abstract

We created a heart failure model of large animals (adult goats), conducted a continuous flow left ventricular assist circulation, transferred SERCA2a gene, which can increase the myocardial contractility, and investigated whether this hybrid therapy could improve and recover the cardiac function. In terms of assist circulation, a synchronized alteration of rotational speed of a continuous flow pump was effective to accelerate the myocardial recovery. Additional gene therapy could increase the myocardial contractility. The synergistic effect of ventricular assist and myocardial regenerative medicine showed the potential to improve prognosis of heart failure patients such as heart transplant candidates

  • Research Products

    (33 results)

All 2013 2012 2011 2010 2009

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (17 results)

  • [Journal Article] Development of a novel drive mode to prevent aortic insufficiency during continuous-flow LVAD support by synchronizing rotational speed with heartbeat.2013

    • Author(s)
      Kishimoto Y, Takewa Y, Arakawa M, Umeki A, Ando M, NishimuraT, Fujii Y, Mizuno T, Nishimura M, Tatsumi E.
    • Journal Title

      J Artif Organs

      Volume: (Epubのみ頁未定)

    • Peer Reviewed
  • [Journal Article] Change in myocardial oxygen consumption employing continuous-flow LVAD with cardiac beat synchronizing system, in acute ischemic heart failure models.2013

    • Author(s)
      Umeki A, Nishimura T, Takewa Y, Ando M, Arakawa M, Kishimoto Y, Tsukiya T, Mizuno T, Kyo S, Ono M, Taenaka Y, Tatsumi E.
    • Journal Title

      J Artif Organs

      Volume: (Epub のみ頁未定)

    • Peer Reviewed
  • [Journal Article] Change of coronary flow by continuous-flow left ventricular assist device with cardiac beat synchronizing system (native heart load control system) in acute ischemic heart failure model.2012

    • Author(s)
      Umeki A, Nishimura T, Ando M, Takewa Y, Yamazaki K, Kyo S, Ono M, Tsukiya T, Mizuno T, Taenaka Y, Tatsumi E.
    • Journal Title

      Circ J

      Volume: 77 Pages: 995-1000

    • DOI

      DOI:10.1111/j.1525-1594.2012.01535.x

    • Peer Reviewed
  • [Journal Article] Creating an ideal "off-test mode" for rotary left ventricular assist devices : establishing a safe and appropriate weaning protocol after myocardial recovery.2012

    • Author(s)
      Ando M, Nishimura T, Takewa Y, Kyo S, Ono M, Taenaka Y, Tatsumi E.
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 143 Pages: 1176-1185

    • DOI

      DOI:10.1016/j.jtcvs.2011.07.065

    • Peer Reviewed
  • [Journal Article] Alteration of LV end-diastolic volume by controlling the power of the continuous-flow LVAD, so it is synchronized with cardiac beat : development of a native heart load control system (NHLCS).2012

    • Author(s)
      Umeki A, NishimuraT, Ando M, Takewa Y, Yamazaki K, Kyo S, Ono M, Tsukiya T, Mizuno T, Taenaka Y, Tatsumi E.
    • Journal Title

      J Artif Organs

      Volume: 15(2) Pages: 128-133

    • DOI

      DOI:10.1007/s10047-011-0615-3

    • Peer Reviewed
  • [Journal Article] Coronary vascular resistance increases under full bypass support of centrifugal pumps-relation between myocardial perfusion and ventricular workload during pump support.2012

    • Author(s)
      Ando M, Takewa Y, Nishimura T, Yamazaki K, Kyo S, Ono M, Tsukiya T, Mizuno T, Taenaka Y, Tatsumi E.
    • Journal Title

      Artif Organs

      Volume: 36 Pages: 105-110

    • DOI

      DOI:10.1111/j.1525-1594.2011.01298.x

    • Peer Reviewed
  • [Journal Article] Electrocardiogram-synchronized rotational speed change mode in rotary pumps could improve pulsatility.2011

    • Author(s)
      Ando M, Nishimura T, Takewa Y, YamazakiK, Kyo S, Ono M, Tsukiya T, Mizuno T, Taenaka Y, Tatsumi E.
    • Journal Title

      Artif Organs

      Volume: 35 Pages: 941-947

    • DOI

      DOI:10.1111/j.1525-1594.2011.01205.x

    • Peer Reviewed
  • [Journal Article] A novel counterpulsation mode of rotary left ventricular assist devices can enhance myocardial perfusion.2011

    • Author(s)
      Ando M, Takewa Y, Nishimura T, Yamazaki K, Kyo S, Ono M, Tsukiya T, Mizuno T, Taenaka Y, Tatsumi E.
    • Journal Title

      J Artif Organs

      Volume: 14 Pages: 185-191

    • DOI

      DOI:10.1007/s10047-011-0573-9

    • Peer Reviewed
  • [Journal Article] What is the ideal off-test trial for continuous-flow ventricular-assist-device explantation? Intracircuit back-flow analysis in a mock circulation model.2011

    • Author(s)
      Ando M, Nishimura T, Takewa Y, Ogawa D, Yamazaki K, Kashiwa K, Kyo S, Ono M, Taenaka Y, Tatsumi E.
    • Journal Title

      J Artif Organs

      Volume: 14 Pages: 70-73

    • DOI

      DOI:10.1007/s10047-010-0543-7

    • Peer Reviewed
  • [Journal Article] A novel couterpulse drive mode of continuous-flow left ventricular assist devices can minimize intracircuit backward flow during pump weaning.2011

    • Author(s)
      Ando M, Nishimura T, TakewaY, OgawaD, Yamazaki K, Kashiwa K, Kyo S, Ono M, Taenaka Y, Tatsumi E.
    • Journal Title

      J Artif Organs

      Volume: 14 Pages: 74-79

    • DOI

      DOI:10.1007/s10047-010-0544-6

    • Peer Reviewed
  • [Journal Article] Development and Hydrodynamic Evaluation of a novel inflow cannula in a mechanical circulatory support system for bridge to decision.2011

    • Author(s)
      Sumikura H, Toda K, Takewa Y, Tsukiya T, Ohnuma K, Sasagawa M, Watanabe F, Ugawa J, Taenaka Y, Tatsumi E.
    • Journal Title

      Artif Organs

      Volume: 35 Pages: 7516-764

    • DOI

      DOI:10.1111/j.1525-1594.2011.01319.x

    • Peer Reviewed
  • [Journal Article] Development of a preclinical model of ischemic cardiomyopathy in swine.2011

    • Author(s)
      Ishikawa K, Ladage D, Takewa Y, Yaniz E, Chen J, Tilemann L, Sakata S, Badimon JJ, Hajjar RJ, Kawase Y.
    • Journal Title

      Am J Physiol-Heart C

      Volume: 301 Pages: H530-H537

    • DOI

      DOI:10.1152/ajpheart.01103.2010

    • Peer Reviewed
  • [Journal Article] Computational fluid dynamic analysis of the flow field in the newly developed inflow cannula for a bridge-to-decision mechanical circulatory support.2011

    • Author(s)
      Tsukiya T, Toda K, Sumikura H, Takewa Y, Watanabe F, Taenaka Y, Tatsumi E.
    • Journal Title

      J Artif Organs

      Volume: 14 Pages: 381-384

    • DOI

      DOI:10.1007/s10047-011-0599-z.

    • Peer Reviewed
  • [Journal Article] In vivo myocardial distribution of multipotent progenitor cells following intracoronary delivery in a swine model of myocardial infarction.2009

    • Author(s)
      Ly HQ, Hoshino K, Pomerantseva I, Kawase Y, Yoneyama R, Takewa Y, Fortier A, Gibbs-Strauss SL, Vooght C, Frangioni JV, Hajjar RJ.
    • Journal Title

      Eur Heart J.

      Volume: 30(23) Pages: 2861-2868

    • DOI

      DOI:10.1093/eurheartj/ehp322

    • Peer Reviewed
  • [Journal Article] Impact of molecular weight in four-branched star vectors with narrow molecular weight distribution on gene delivery efficiency.2009

    • Author(s)
      Nemoto Y, Borovkov A, Zhou YM, Takewa Y, Tatsumi E, Nakayama Y.
    • Journal Title

      Bioconjug Chem.

      Volume: 20 Pages: 2293-2299

    • DOI

      DOI:10.1021/bc900283h

    • Peer Reviewed
  • [Journal Article] Mechanical work and energetic analysis of eccentric cardiac remodeling in a volume overload heart failure in rats.2009

    • Author(s)
      Takewa Y, Chemaly ER, Takaki M, Liang LF,Jin H, Karakikes I, Morel C, Taenaka Y, Tatsumi E, Hajjar RJ.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 296 Pages: H1117-H1124

    • DOI

      DOI:10.1152/ajpheart.01120.2008

    • Peer Reviewed
  • [Presentation] Optimization of the coronary flow by a novel cardiac cycle-synchronized rotation control model in a continuous-flow LVAD in chronic heart failure model.2012

    • Author(s)
      Arakawa M, Takewa Y, Nishimura T, Umeki A, Ando M, Kishimoto Y, Mizuno T, Tsukiya T, Kyo S, Adachi H, Tatsumi E
    • Organizer
      European Society for Artificial Organs
    • Place of Presentation
      Rostock (Germany)
    • Year and Date
      20120926-20120929
  • [Presentation] Development of a novel drive mode for preventing aortic insufficiency during continuous-flow LVAD support by electrocardiogram-synchronized rotational speed change.2012

    • Author(s)
      Kishimoto Y, Arakawa M, Umeki A, Ando M, Nishimura T, Takewa Y, Niashimura M, Tatsumi E.
    • Organizer
      European Society for Artificial Organs
    • Place of Presentation
      Rostock (Germany)
    • Year and Date
      20120926-20120929
  • [Presentation] Electrocardiogram-synchronized rotational speed change mode in rotary pumps could improve pulsatility for long time use.2012

    • Author(s)
      Arakawa M, Takewa Y, Nishimura T, Kishimoto Y, Umeki A, Ando M, Kyo S, Adachi H, Tatsumi E.
    • Organizer
      International Society for Rotary Blood Pumps
    • Place of Presentation
      Istanbul (turkey)
    • Year and Date
      20120920-20120922
  • [Presentation] How to set up rotational speeds in rotary LVADs weaning-estimation of heart work by pump work calculation called "W pump".2012

    • Author(s)
      Ando M, Nishimura T, Takewa Y, Tsukiya T, Mizuno T, Yamazaki K, Kyo S, Ono M, Taenaka Y, Tatsumi E.
    • Organizer
      International Society for Rotary Blood Pumps
    • Place of Presentation
      Istanbul (turkey)
    • Year and Date
      20120920-20120922
  • [Presentation] The continuous flow LVAD with native heart load control system (NHLCS) may have more chance to recover the ventricular contractility.2012

    • Author(s)
      Umeki A, Nishimura T, Takewa Y, Ando M, Mizuno T, Tsukiya T, Kyo S, Taenaka Y, Ono M, Tatsumi E.
    • Organizer
      International Society for Rotary Blood Pumps
    • Place of Presentation
      Istanbul (turkey)
    • Year and Date
      20120920-20120922
  • [Presentation] A novel drive mode of continuous-flow LVAD with cardiac cycle-synchronized rotation control for preventing aortic insufficiency during long-term support, evaluation in chronic heart failure animal model.2012

    • Author(s)
      Kishimoto Y, Arakawa M, Umeki A, Ando M, Nishimura T, Takewa Y, Nishimura M, Tatsumi E.
    • Organizer
      International Society for Rotary Blood Pumps
    • Place of Presentation
      Istanbul (turkey)
    • Year and Date
      20120920-20120920
  • [Presentation] Prevention of aortic insufficiency in a continuous flow LVAD by changing rotation speed in synchronization with the cardiac beat.2012

    • Author(s)
      Kishimoto Y, Arakawa M, Umeki A, Ando M, Nishimura T, Takewa Y, Nishimura M, Tatsumi E.
    • Organizer
      American Society for Artificial Internal Organs
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      20120613-20120616
  • [Presentation] Ventricular septum shift by continuous-flow LVAD pumping and its correction by beat to beat rotational speed control.2012

    • Author(s)
      Arakawa M,Takewa Y, Nishimura T, Kishimoto Y, Umeki A, Ando M, Kyo S, Adachi H, Tatsumi E.
    • Organizer
      American Society for Artificial Internal Organs
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      20120613-20120616
  • [Presentation] Alternation of LV preload by continuous-flow LVAD with native heart load control system (NHLCS) in chronic heart failure model.2012

    • Author(s)
      Arakawa M, Takewa Y, Nishimura T, Umeki A, Ando M, Kishimoto Y, Kyo S, Adachi H, Tatsumi E.
    • Organizer
      American Society for Artificial Internal Organs
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      20120613-20120616
  • [Presentation] Electrocardiogram-synchronized rotational speed change mode in rotary pumps could improve pulsatility for long time use.2012

    • Author(s)
      Arakawa M, Takewa Y, Nishimura T, Kishimoto Y, Umeki A, Ando M, Kyo S, Adachi H, Tatsumi E.
    • Organizer
      American Society for Artificial Internal Organs
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      20120613-20120616
  • [Presentation] The continuous flow LVAD with native heart load control system (NHLCS) for bridge to recovery could control the coronary flow and myocardial oxygen consumption in acute heart failure model.2011

    • Author(s)
      Nishimura T, Umeki A, Takewa Y, Ando M, Mizuno T, Tsukiya T, Yamazaki K, Ono M, Kyo S, Taenaka Y, Tatsumi E.
    • Organizer
      Joint ESAO-IFAO Congress
    • Place of Presentation
      Porto (Portugal)
    • Year and Date
      20111009-20111012
  • [Presentation] Ideal Controlling mode (Off test mode) for evaluating the native heart function in time of wearing the LVAD : Controlling the power of continuous flow LVAD to decrease the reversal pump flow in diastolic phase.2011

    • Author(s)
      Umeki A, Takewa Y, Nishimura T, Ando M, Ono M, Kyo S, Tatsumi E.
    • Organizer
      Congress of the International Society for Rotary Blood Pumps
    • Place of Presentation
      Louisville (USA)
    • Year and Date
      20110908-20110910
  • [Presentation] The change of coronary flow by controlling the power of continuous-flow left ventricular assist device in acute heart failure : Counterpulse drive mode can increase the coronary flow.2011

    • Author(s)
      Umeki A, Takewa Y, Nishimura T, Ando M, Mizuno T, Tsukiya T, Ono M, Kyo S, Yamazaki K, Taenaka Y, Tatsumi E.
    • Organizer
      American Society for Artificial Internal Organs
    • Place of Presentation
      Washington D.C. (USA)
    • Year and Date
      20110610-20110612
  • [Presentation] The continuous-flow LVAD with native heart load control system(NHLCS) for bridge to recovery could control myocardial consumption of oxygen in acute heart failure model.2011

    • Author(s)
      Nishimura T, Umeki A, Takewa Y, Ando M, Tsukiya T, Mizuno T, Kyo S, Ono M, Yamazaki K, Taenaka Y, Tatsumi E.
    • Organizer
      American Society for Artificial Internal Organs
    • Place of Presentation
      Washington D.C. (USA)
    • Year and Date
      20110610-20110612
  • [Presentation] Pulsatility can be created in rotary pumps by ECG-synchronized rotation speed change mode.2010

    • Author(s)
      ndo M, Nishimura T, Takewa Y, Yamazaki K, Kyo S, Ono M, Tatsumi E.
    • Organizer
      International Society for Rotary Blood Pumps
    • Year and Date
      20101014-20101016
  • [Presentation] Full bypass by a continuous-flow left ventricular assist device can diminish coronary flow in normal goat hearts.2010

    • Author(s)
      Ando M, Nishimura T, Takewa Y, Yamazaki K, Kyo S, Ono M, Tatsumi E.
    • Organizer
      European Society for Artificial Organs
    • Year and Date
      20100908-20100911
  • [Presentation] A novel counterpulse drive mode in a continuous-flow left ventricular assist device effect on coronary circulation.2010

    • Author(s)
      Ando M, Takewa Y, Nishimura T, Yamazaki K, Kyo S, Ono M, Taenaka Y, Tatsumi E.
    • Organizer
      American Society for Artificial Internal Organs
    • Place of Presentation
      Baltimore (USA)
    • Year and Date
      20100527-20100529

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Published: 2014-08-29   Modified: 2014-09-05  

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