2011 Fiscal Year Final Research Report
Elucidation of neuronal regenerative mechanism after ischemia and its modulation therapy
| Project/Area Number |
21390413
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脳虚血 / 神経細胞死 / 神経再生 / 線条体 |
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| Research Abstract |
Here we explored whether neuronal regeneration can be augmented by administration of exogenous growth factors by using rat global ischemia model, which induced selective neuronal death in the striatum. As a result, neuronal density in the striatum decreased to 1% by 2 days after ischemia, that was finally increased to 12-15% by the growth factor treatment. When dividing neural progenitors were labeled by BrdU, the progeny of these cells were distributed in the striatum, differentiated into region specific projection and inter-neurons. In addition, these cells maturated electrophysiologically after 20 weeks of ischemia. Motor performance also improved significantly. Collective, these results suggested that the modulation of endogenous neuronal regeneration can be potentiated by the treatment, and finally leads to functional recovery.
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