2011 Fiscal Year Final Research Report
Comprehensive Study on Experimental Proof of Fetal Origins of Adult Diseases Hypothesis and its Clinical Application
| Project/Area Number |
21390451
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Mie University |
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Principal Investigator |
SAGAWA Norimasa 三重大学, 大学院・医学系研究科, リサーチアソシエイト (00162321)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIYAMA Takashi 三重大学, 医学部附属病院, 准教授 (10263005)
UMEKAWA Takashi 三重大学, 医学部附属病院, 助教 (80422864)
KAMIMOTO Yuki 三重大学, 医学部附属病院, 助教 (90422865)
MURABAYASHI Nao 三重大学, 医学部附属病院, 助教 (10378416)
MIZOGUCHI Akira 三重大学, 大学院・医学系研究科, 教授 (90181916)
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| Co-Investigator(Renkei-kenkyūsha) |
YURA Shigeo 京都大学, 大学院・医学研究科, 講師 (60335289)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 妊娠 / 子宮内環境 / 胎児プログラミング / 成人病 / 糖脂質代謝 / インスリン抵抗性 / 高血圧 / 脂肪組織の慢性炎症 |
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| Research Abstract |
The aim of this study was to confirm the fetal origins of adult disease hypothesis and to explore a tool to prevent adult diseases of fetal origins. We found that hypertension in the offspring exposed to under nutrition in utero was closely related to activation of cardiac angiotensin system and that development of hypertension in these offspring was blocked by feeding high protein diet or branched chain amino acid to the pregnant mother. Maternal obesity is another cause of perinatal morbidity such as gestational diabetes and pregnancy-induced hypertension. Therefore, we also examined the effect of maternal high-fat diet on both mother and fetus. We found that high fat diet caused not only maternal obesity and impaired glucose tolerance but also hypertension and impaired glucose tolerance in the next generation through chronic inflammation of fat tissue of the fetus.
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[Journal Article] Transgenic mice overproducing human thioredoxin-1, an antioxidative and anti-apoptotic protein, prevents diabetic embryopathy2010
Author(s)
Yuki Kamimoto, Takashi Sugiyama, Tomohisa Kihira, Lingyun Zhang, Nao Murabayashi, Takashi Umekawa, Kenji Nagao, Ning Ma, Nagayasu Toyoda, Junji Yodoi, Norimasa Sagawa
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Journal Title
Diabetologia
Volume: 53
Pages: 2046-2055
Peer Reviewed
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[Journal Article] Isocaloric high-protein diet ameliorates systolic blood pressure increase and cardiac remodeling caused by maternal caloric restriction in adult mouse offspring.2009
Author(s)
Makoto Kawamura, Hiroaki Itoh, Shigeo Yura, Hirota Mogami, Tsuyoshi Fujii, Hisashi Makino, Yoshihiro Miyamoto, Yasunao Yoshimasa, Seiichiro Aoe, Yoshihiro Ogawa, Norimasa Sagawa, Norio Kanayama, Ikuo Konishi
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Journal Title
Endocrine J
Volume: 56(5)
Pages: 679-689
Peer Reviewed
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