2011 Fiscal Year Final Research Report
Characterization of mouse models for glaucoma
| Project/Area Number |
21390471
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | 独立行政法人国立病院機構東京医療センター(臨床研究センター) (2011)
独立行政法人国立病院機構(東京医療センター臨床研究センター) (2009-2010) |
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Principal Investigator |
IWATA Takeshi 独立行政法人国立病院機構東京医療センター(臨床研究センター), 分子細胞生物学研究部, 部長 (90374157)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZOTA Atsushi 帝京大学, 眼科学講座, 教授 (10239262)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 緑内障 / オプチニュリン / WDR36 / Vav2 / Vav3 / トランスジェニックマウス |
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| Research Abstract |
Glaucoma is a multifactorial disease influenced by genetic and environment factors. The molecular mechanism of the glaucoma onset still remains unclear. In this study we focused on 4 genes, optineurin, WDR36, vav2, and vav3 to develop and characterize the mouse model for glaucoma.
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[Journal Article] Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice2010
Author(s)
Chi Z-L, Akahori, A, Obazawa M, Minami M, Noda T, Nakaya N, Tomarev S, Kawase K, Yamamoto T, Noda S, Sasaoka M, Shimazaki A, Takada Y, and Iwata T.
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Journal Title
Human Molecular Genetics
Volume: 19
Pages: 2605-2615
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[Presentation] Overexpression of mutant OPTN and WDR36 leads to a progressive retinal degeneration in mice2010
Author(s)
Chi ZL. Akahori M, Obazawa M, Minami M, Noda T, Nakaya N, Tomarev S, Kawase K, Yamamoto T, Noda S, Sasaoka M, Shimazaki A, Sergeev Y, Takada Y, Iwata T.
Organizer
50th American Society for Cell Biology
Year and Date
20101100
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