2011 Fiscal Year Final Research Report
Elucidation of development mechanism and molecular targets in neuroblastoma and hepatoblastoma using genomics and cellomics
| Project/Area Number |
21390474
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
HIYAMA Eiso 広島大学, 自然科学研究支援開発センター, 教授 (00218744)
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| Co-Investigator(Kenkyū-buntansha) |
MASUJIMA Tsutomu 広島大学, 医歯薬学総合研究科, 教授 (10136054)
SOTOMARU Yusuke 広島大学, 自然科学研究支援開発センタ, 教授 (90309352)
KAMIMATSUSE Arata 広島大学, 病院, 病院助教 (90569881)
YAMAOKA Hiroaki 広島大学, 病院, 講師 (90311810)
HIYAMA Keiko 広島大学, 原爆放射線医科学研究所, 准教 (60253069)
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| Co-Investigator(Renkei-kenkyūsha) |
00TAKI Megu 広島大学, 原爆放射線医科学研究所, 教授 (20110463)
NAKAGAWARA Akira 千葉県がんセンター(研究所), 研究局, 局長 (50117181)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 癌 / ゲノム / 細胞・組織 / 発生・分化 / トランスレーショナルリサーチ |
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| Research Abstract |
In childhood cancers, the tumors derived from abnormal differentiation show favorable outcomes, while highly malignant tumors contain cancer stem cells and have a high frequency of relapse. In the present study, we isolated cancer stem cells from neuroblastoma and hepatoblastoma samples and analyzed their characteristics using genomics and one cell proteomics(Cellomics). In these cancer stem cells, neurodifferentiative pathway and glutamate metabolism were inhibited but several molecules including Bim-1 and Notch-1 were up-regulated. Among these molecules, we identified the molecule which was elevated in serum of the cases with unfavorable outcomes. This molecule is considered as a useful candidate for detecting cancer stem cells in childhood cancer patients
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[Journal Article] Outcome of hepatob lastomas treated using the Japanese St udy Group for Pediatric Liver Tumor(J PLT) protocol-2 : report from the JPLT2011
Author(s)
Hishiki T, Matsunaga, Watana be K, Oue T, Tajiri T, Kamimatsuse A, Ohnuma N, Hiyama E. T, Sasaki F, Y ano M, Ida K, Horie H, Kondo S.
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Journal Title
Pediatric Surgery International
Volume: 27(1)
Pages: 1-8
DOI
Peer Reviewed
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[Journal Article] Genome-wide analysis of allelic imbalances reveals 4q deletions a s a poor prognostic factor and MDM4 amplification at 1q32. 1 in hepatoblastoma2010
Author(s)
Arai Y, Honda S, Haruta M, Kasai F, Fujiwara Y, Ohshima J, Sasaki F, Nakagawara A, Horie H, Yamaoka H, Hiyama E, Kaneko Y.
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Journal Title
Genes Chromosomes Cancer.
Volume: 49(7)
Pages: 596-609
DOI
Peer Reviewed
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[Journal Article] Preimpla ntati on development of somatic cell clo ned embryos in the common marmoset(Calli thrix jacchus)2009
Author(s)
Sotomaru Y, Hirakawa R, Shimada A, Shiozawa S, Sugawara A, Oiwa R, Nob ukiyo A, Okano H, Tamaoki N, No mura T, Hiyama E, Sasaki E.
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Journal Title
Cloning Stem Cells
Volume: 11(4)
Pages: 575-583
DOI
Peer Reviewed
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