2012 Fiscal Year Final Research Report
Roles of cancer stem cells in the development and progression of cancer metastasis to bone
| Project/Area Number |
21390505
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
HIRAGA Toru 松本歯科大学, 歯学部, 准教授 (70322170)
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| Co-Investigator(Kenkyū-buntansha) |
HOSOYA Akihiro 松本歯科大学, 歯学部, 講師 (70350824)
NINOMIYA Tadashi 松本歯科大学, 総合歯科医学研究所, 講師 (00360222)
KOBAYASHI Yasuhiro 松本歯科大学, 総合歯科医学研究所, 准教授 (20264252)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 癌 / 癌幹細胞 / 骨転移 |
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| Research Abstract |
Bone is one of the most preferential sites for cancer metastasis; however, the precise mechanisms are still unclear. An increasing body of evidence suggests that cancers contain a small subset of their own stem-like cells called cancer stem cells (CSCs), which play critical roles in the initiation, maintenance and relapse of tumors. In this study, we studied the role of CSCs in cancer metastasis to bone. Flow cytometric analysis revealed the existence of CSC marker-positive cells in several kinds of cancer cell lines. Those cells exhibited some of the CSC-like properties in vitro and in vivo. However, the bone-metastatic potential of side population (SP) cells, which has been shown to enrich CSCs in several types of cancer, was similar to that of non-SP cells. Further studies are required to clarify the contribution of CSCs to cancer bone metastasis.
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[Journal Article] Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.2012
Author(s)
Maeda K, Kobayashi Y, Udagawa N, UeharaS, Ishihara A, Mizoguchi T, Kikuchi Y, Takada I, Kato S, Kani S, Nishita M, Marumo K, Martin TJ, Minami Y, Takahashi N.
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Journal Title
Nat Med
Volume: 18(3)
Pages: 405-12
DOI
Peer Reviewed
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[Journal Article] Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice.2010
Author(s)
Kobayashi Y, Hiraga T, Ueda A, Wang L, Matsumoto-Nakano M, Hata K, Yatani H, Yoneda T.
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Journal Title
J Bone Miner Metab
Volume: 28(2)
Pages: 165-75
DOI
Peer Reviewed
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[Journal Article] Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.2009
Author(s)
Mizoguchi T, Muto A, Udagawa N, Arai A, Yamashita T, Hosoya A, Ninomiya T, Nakamura H, Yamamoto Y, Kinugawa S, Nakamura M, Nakamichi Y, Kobayashi Y, Nagasawa S, Oda K, Tanaka H, Tagaya M, Penninger JM, Ito M, Takahashi N.
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Journal Title
J Cell Biol
Volume: 184(4)
Pages: 541-54
DOI
Peer Reviewed
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