2011 Fiscal Year Final Research Report
Tissue engineering of tooth root with periodontium generated from cells in adult teeth.
| Project/Area Number |
21390528
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
HONDA Masaki 日本大学, 歯学部, 准教授 (70361623)
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| Co-Investigator(Kenkyū-buntansha) |
ISOKAWA Keitaro 日本大学, 歯学部, 教授 (50168283)
YUGUCHI Maki 日本大学, 歯学部, 助手 (00256885)
MIKAMI Yoshikazu 日本大学, 歯学部, 助教 (80434075)
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Nobukazu 東京大学, 医科学研究所, 准教授 (10334278)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 再生歯学 |
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| Research Abstract |
We performed a series of experiment for a development of method to generate a tooth-root with periodontium in the limited three years. In the first years, we developed the method to isolate and culture the dental follicle-derived cells, human periodontal ligament-derived, and human pulp-derived mesenchymal cells. In the second year, the suitable scaffolds to generate dentin tissues were examined using dental pulp-derived mesenchymal cells. In the last year, we create the bone trunk and implanted the mimic tooth germ including enamel organ-derived, dental pulp-derived, and dental follicle-derived cells in the bone trunk. After implantation, periodontal ligament-like tissue on the surface of cementum-like tissues was observed in the bone trunk.
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[Journal Article] Oral bacterial extracts facilitate early osteogenic/dentinogenic differentiation in human dental pulp-derived cells2010
Author(s)
Abe S, Imaizumi M, Mikami Y, Wada Y, Satomura K, Ishihara K, Honda MJ
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Journal Title
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Volume: 109
Pages: 149-154
Peer Reviewed
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