2011 Fiscal Year Final Research Report

Analysis of optimal dose of anticancer drug in superselective intra-arterial infusion using computational fluid dynamics based on biomedical engineering

Research Project

Project/Area Number	21390542
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Surgical dentistry
Research Institution	Yokohama City University
Principal Investigator	TOHNAI Iwai 横浜市立大学, 医学研究科, 教授 (50172127)
Co-Investigator(Kenkyū-buntansha)	MITSUDOU Kenji 横浜市立大学, 医学部, 准教授 (70303641) IWAI Toshinori 横浜市立大学, 附属病院, 助教 (00468191)
Co-Investigator(Renkei-kenkyūsha)	OSHIMA Marie 東京大学, 情報学環, 教授 (40242127)
Project Period (FY)	2009 – 2011
Keywords	口腔癌 / 動注化学療法 / 流体解析 / 流体シミュレーション
Research Abstract	To clarify distribution of anticancer drug to tumor feeding artery or metastatic lymph node in intra-arterial infusion for oral cancer, we developed blood flow simulation of the external carotid artery and its branch using computational fluid dynamics. For accurate simulation, we applied 0D model with peripheral network and assessment of the simulation was performed using blood flow of the superficial temporal artery. The error of this simulation was about 5%, and the base of patient-specific blood flow simulation of the external carotid artery and its branch was established.

(1 results)