2011 Fiscal Year Final Research Report
Epoch-making approach for tooth root regeneration using human iPS cells
| Project/Area Number |
21390546
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Meikai University (2010-2011)
Tokyo Medical and Dental University (2009) |
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Principal Investigator |
SUDA Naoto 明海大学, 歯学部, 教授 (90302885)
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| Co-Investigator(Kenkyū-buntansha) |
ISEKI Sachiko 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (80251544)
OHTA Masato 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (70313228)
MATSUI Shigeyuki 明海大学, 歯学部, 准教授 (40190392)
YOSHIKAWA Masayoshi 明海大学, 歯学部, 講師 (80200963)
MANO Mikiko 明海大学, 歯学部, 講師 (00333005)
SAKURAI Yousuke 明海大学, 歯学部, 助教 (20529630)
SASAKI Au 明海大学, 歯学部, 助教 (60580230)
KOUHARA Manabu 明海大学, 歯学部, 助教 (40602529)
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| Project Period (FY) |
2009 – 2011
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| Keywords | iPS細胞 / 歯根 / 組織再生 / 3次元構築 |
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| Research Abstract |
The human specific TaqMan probes for DSPP and GAPDH which were not recognized by mouse sequences were designed. To test the appropriate feeder cells for the differentiation of iPS cells to DSPP expressing cells, mouse embryonic fibroblasts were found to be most potent. More than 10 growth factors and cytokines were tested for the differentiation, and TGF-ss was the most effective molecule. An analyzing system for the three-dimensional tooth root structure using DICOM data was also established.
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[Journal Article] Dental and maxillofacial characteristics in six Japanese individuals with ectrodactyly-ectodermal dysplasia-clefting(EEC) syndrome2012
Author(s)
Okamura E, Suda N, Baba Y, Fukuoka H, Ogawa T, Ohkuma M, Ahiko N, Yasue A, Tengan T, Shiga M, Tsuji M, Moriyama K
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Journal Title
Cleft Palate Craniofac J
Volume: (印刷中)
DOI
Peer Reviewed
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[Journal Article] ADAMTSL6ss rescues fibrillin-1 microfibril disorder in Marfan syndrome mouse model through the promotion of fibrillin-1 assembly2011
Author(s)
Saito M, Kurokawa M, Oda M, Oshima M, Tsutsui K, Kosaka K, Nakao K, Ogawa M, Manabe RI, Suda N, Ganjargal G, Hada Y, Noguchi T, Teranaka T, Sekiguchi K, Yoneda T, Tsuji T
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Journal Title
J Biol Chem
Volume: 286
Pages: 38602-13
DOI
Peer Reviewed
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[Presentation] 顔面非対称を伴う線維性骨異形成症の1例2011
Author(s)
藤田昌樹, 吉川紀之, 平池正人, 永山英恵, 三上早奈英, 西野広人, 江川里沙, 吉川正芳, 打矢五月, 森一将, 嶋田淳, 須田直人
Organizer
第70回東京矯正歯科学会
Place of Presentation
東京
Year and Date
20110720-21
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