2011 Fiscal Year Final Research Report
Elucidation of the influence that degradation of renal function with aging gives to bone metabolism and periodontal disease
| Project/Area Number |
21390558
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Hideo 新潟大学, 医歯学系, 教授 (00157629)
ITO Kayoko 新潟大学, 医歯学総合病院, 助教 (80401735)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 含公衆衛生学 / 栄養学 |
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| Research Abstract |
This study examined whether low renal function is associated with the bone metabolism and contributing to periodontal disease among community-dwelling elderly Japanese. We selected 674 subjects aged from 55 to 74 years old. Serum cystatin C level was used to assess renal dysfunction. There were significant relationship between serum systatin C level at baseline and the number of remaining teeth or between serum systatin C longitudinal change and the number of missing teeth. In addition, multiple regression analysis showed that the percentage of sites with> 4mm or> 6mm clinical attachment levels was significantly associated with serum osteocalcin levels. Low renal function and reduction of renal function were associated with periodontal disease including tooth loss.
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