Social anthropological study for genotypes of oral Candida albicans from healthy people in Central Asia

2013 Fiscal Year Final Research Report

• Project/Area Number: 21405002
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Resource conservation science
• Research Institution: Chiba University
• Principal Investigator: TANAKA Reiko 千葉大学, 真菌医学研究センター, 助教 (60143319)
• Co-Investigator(Kenkyū-buntansha): KANBE Toshio 名古屋大学, 医学研究科, 講師 (50093018) ; YAGUCHI Takashi 千葉大学, 真菌医学研究センター, 准教授 (60361440) ; MATSUZAWA Tetsuhiro 千葉大学, 真菌医学研究センター, 技術職員 (40598702)
• Project Period (FY): 2009-04-01 – 2014-03-31
• Keywords: カンジダ・アルビカンス / 民族 / 常在性 / 遺伝子型 / 新疆ウイグル自治区 / トルコ

Research Abstract

Candida albicans are known to be one of normal oral resident microorganisms. We developed some tools for discrimination of C. albicans . We aim to know the relation between race and their genotypes of C. albicans. In old literature, Japanese people were originated from Central Asia (Mongolian). The Silk Road (from the ancient the Roman Empire to Japan through Turkey and Xinjiang) is very interesting route of people moving. We surveyed their genotypes in Japan, Xinjiang (Turpan, Ili, Kashgar) and Turkey (Adana).
The genotype common to all was found in comparison of the genotype for every area. Moreover, although characteristic main genotypes were found in every area, there was nothing in Kashgar. This result showed that genotypes were very various in Kashgar. In Adana (Turkey), the frequency of genotype D was very high, and the feature of this area was shown. As mentioned above, the feature peculiar to the area was able to be found out by comparison of the genotype.

Research Products

• [Journal Article] Genotypes of Candida albicans isolated from healthy individuals and their distribution in patients with oral candidiasis (2013)
  • Author(s): Takagi Y, Fukano H, Shimozato K, Tanaka R, Horii T, Kawamoto F, Kanbe T
  • Journal Title: J Infct Chemother Volume: 19 Pages: 1072-1079
  • DOI: 10.1007/s10156-013-0626-5
  • Peer Reviewed
• [Journal Article] Genotypes of Candia albicans involved in development of candidiasis and their distribution in oral cavity of no-candidiasis individuals (2011)
  • Author(s): Takagi Y, Hattori H, Adachi H, Takakura S, Horii T, Chindamporn A, Kitai H, Tanaka R, Yaguchi T, Fukano H, Kawamoto F, Shimozato K, Kanbe T
  • Journal Title: Med Mycol J Volume: 52 Pages: 315-324
  • DOI: 10.3314/mmj.52.315
  • Peer Reviewed
• [Journal Article] Microsatellite-based genotyping of Candida albicans isolated from patients with superficial candidiasis (2011)
  • Author(s): Shimizu K, Hattori H, Adachi H, Oshima R, Horii T, Tanaka R, Yaguchi T, Tomita Y, Akiyama M, Kawamoto F, Kanbe T
  • Journal Title: Med Mycol J Volume: 52 Pages: 129-138
  • DOI: 10.3314/jjmm.52.129
  • Peer Reviewed
• [Journal Article] Genotyping of fluconazole- resistant Candida albicans isolated from Uighurian living in Xinjiang (China), using ALTS/RFLP and μ-TGGE method (2010)
  • Author(s): Mijiti J, XM Pu, Erfan A, Yaguchi T, Chibana H, Tanaka R
  • Journal Title: Jpn J Med Mycol Volume: 51 Pages: 165-168
  • DOI: 10.3314/jjmm.51.165
  • Peer Reviewed
• [Journal Article] Genotyping of Candida albicans by fragment analysis of microsatellites combined with 25S rDNA and RPS-based strategies (2009)
  • Author(s): Adachi H, Shimizu K, Hattori H, Tanaka R, Chinbana H, Takagi Y, Tomita Y, Kanbe T
  • Journal Title: Jpn J Med Mycol Volume: 50 Pages: 167-174
  • DOI: 10.3314/jjmm.50.167
  • Peer Reviewed
• [Presentation] Genetic and phenotypic heterogeneity in clinical Candida albicans isoletes from Beijing, China (2011)
  • Author(s): Li HM, Imanishi Y, Tanaka R, Li RY, Yaguchi T
  • Organizer: IUMS 2011
  • Place of Presentation: Sapporo
  • Year and Date: 20110906-10
• [Presentation] Candida albicans 交配能に関わる現象の再検討 (2010)
  • Author(s): 今西由巳, 李 厚敏, 田中玲子, 李 若瑜, 矢口貴志
  • Organizer: 第55回日本医真菌学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20101021-22
• [Presentation] Microsatellite 解析に基づいたカンジダ症と Candida albicans genotype の関係 (2010)
  • Author(s): 高木雄基, 深野英夫, 田中玲子, 矢口貴志, 神戸俊夫
  • Organizer: 第55回日本医真菌学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20101021-22
• [Presentation] ヒト口腔内常在性Candida albicans のgenotype解析 (2010)
  • Author(s): 高木雄基, 服部尚生, 足立秀禎, 田中玲子, 深野英夫, 神戸俊夫
  • Organizer: 第54回日本医真菌学会総会
  • Place of Presentation: 東京
  • Year and Date: 20101016-17
• [Presentation] Genotyping of Candida albicans spp. Isolated from oral candidiasis of HIV/AIDS infected patients in Indonesia : A molecular epidemiological studies (2010)
  • Author(s): Khaedir Y, Tanaka R, Tarini A, Mijiti J, Gonoi T
  • Organizer: IMC9 : The Biology of Fungi
  • Place of Presentation: Edinburgh, UK
  • Year and Date: 20100801-06