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2012 Fiscal Year Final Research Report

Study for preventing epidemic of viral zoonoses in Japan and theAmerican Continents

Research Project

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Project/Area Number 21405035
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Applied veterinary science
Research InstitutionHokkaido University

Principal Investigator

KARIWA Hiroaki  北海道大学, 大学院・獣医学研究科, 准教授 (70224714)

Co-Investigator(Kenkyū-buntansha) ARIKAWA Jiro  北海道大学, 大学院・医学研究科, 教授 (10142704)
YOSHII Kentaro  北海道大学, 大学院・獣医学研究科, 助教 (50421988)
MORIMATSU Kumiko  北海道大学, 大学院・医学研究科, 准教授 (90220722)
Project Period (FY) 2009 – 2012
Keywords人獣共通感染症 / ハンタウイルス / ウエストナイルウイルス / げっ歯類 / 鳥類
Research Abstract

Three novel hantaviruses were detected in Mexican rodents. The antibody detection method for various hantavirus infections was developed. Five of six monoclonal antibodies to nucleocapsid protein (NP) of Mexican hantavirus were broadly reacted with NPs of rodent-borne hantaviruses. Glycosylation of West Nile virus E protein made great influence in the pathogenesis in chicks infected with West Nile virus.

  • Research Products

    (43 results)

All 2012 2011 2010 2009

All Journal Article (25 results) (of which Peer Reviewed: 20 results) Presentation (15 results) Book (3 results)

  • [Journal Article] Infection of Hantaan virus strain AA57 leading to pulmonary disease in laboratory mice2012

    • Author(s)
      Seto T, Yoshii K, Kariwa H.
    • Journal Title

      Virus Res

      Volume: 163 Pages: 284-290

    • Peer Reviewed
  • [Journal Article] Genetic diversity of hantaviruses inMexico: Identification of three novel hantaviruses from Neotominae rodents2012

    • Author(s)
      Kariwa H, Yoshii K, Yoshimatsu K, Arikawa J
    • Journal Title

      Virus Res

      Volume: 163 Pages: 486-494

    • Peer Reviewed
  • [Journal Article] Isolation and characterization of hantaviruses in far East Russia and etiology of hemorrhagic Fever with renal syndrome in the region2012

    • Author(s)
      Kariwa H, Yoshimatsu K, Arikawa J, Yoshii K
    • Journal Title

      Am J Trop Med Hyg

      Volume: 86 Pages: 545-553

    • Peer Reviewed
  • [Journal Article] The Conserved Region in the PrM Protein Is a Critical Determinant in the Assembly of Flavivirus Particles2012

    • Author(s)
      Yoshii K, Kariwa H, Takashima I
    • Journal Title

      J Gen Virol

      Volume: 93 Pages: 27-38

    • Peer Reviewed
  • [Journal Article] The N-terminus of the Montano virus nucleocapsid protein possesses broadly cross-reactive conformation- dependent epitopes conserved in rodent- borne hantaviruses2012

    • Author(s)
      Saasa N, Yoshii K, Yoshimatsu K, ArikawaJ, Kariwa H
    • Journal Title

      Virology

      Volume: 428 Pages: 48-57

    • Peer Reviewed
  • [Journal Article] Ecology of hantaviruses inMexico: Genetic identification of rodent host species and spillover infection2012

    • Author(s)
      Saasa N, Yoshii K, Yoshimatsu K, ArikawaJ, Kariwa H
    • Journal Title

      Virus Res

      Volume: 168 Pages: 88-96

    • Peer Reviewed
  • [Journal Article] Development of a diagnostic method applicable to various serotypes of hantavirus infection in rodents2012

    • Author(s)
      Sanada T, Kariwa H, Yoshimatsu K, Arikawa J, Yoshii K
    • Journal Title

      J Vet Med Sci

      Volume: 74 Pages: 1237-1242

    • Peer Reviewed
  • [Journal Article] Isolation of Hokkaido virus, genus Hantavirus, using a newlyestablished cell line derived from the kidney of the grey red-backed vole (Myodes rufocanus bedfordiae)2012

    • Author(s)
      Sanada T, Yoshimatsu K, Arikawa J, Yoshii K, Kariwa H
    • Journal Title

      J Gen Virol

      Volume: 93 Pages: 2237-2246

    • Peer Reviewed
  • [Journal Article] 2008年北海道におけるダニ媒介性脳炎ウイルスの分離と性状解析2012

    • Author(s)
      好井健太朗, 山崎翔子, 持舘景太, 苅和宏明, 高島郁夫
    • Journal Title

      獣医畜産新報

      Volume: 65 Pages: 377-378

  • [Journal Article] Construction of an infectious cDNA clone for Omsk hemorrhagic fever virus, and characterization of mutations in NS2A and NS52011

    • Author(s)
      Yoshii K, IKariwa H, Takashima I
    • Journal Title

      Virus Res

      Volume: 155 Pages: 61-68

    • Peer Reviewed
  • [Journal Article] Epizootiological Study of Tick-Borne Encephalitis Virus Infection in Japan2011

    • Author(s)
      Yoshii K, Kariwa H, Takashima I
    • Journal Title

      J Vet Med Sci

      Volume: 73 Pages: 409-412

    • Peer Reviewed
  • [Journal Article] An Efficient in vivo Method for the Isolation OF Puumala Virus in Syrian Hamsters and the Characterization of the isolates from Russia2011

    • Author(s)
      Seto T, Yoshii K, Yoshimatsu K, Arikawa J, Kariwa H
    • Journal Title

      J Virol Methods

      Volume: 173 Pages: 17-23

    • Peer Reviewed
  • [Journal Article] Development of ELISA system for tick-borne encephalitis virusinfection in rodents2011

    • Author(s)
      Ikawa-Yoshida A, Yoshii K, Kariwa H
    • Journal Title

      Microbiol Immunol

      Volume: 55 Pages: 100-107

    • Peer Reviewed
  • [Journal Article] Seroprevalence of West Nile Virus in Wild Birds in Far Eastern Russia Using a Focus Reduction Neutralization Test.2011

    • Author(s)
      Murata R, Yoshii K, Kariwa H
    • Journal Title

      Am J Trop Med Hyg

      Volume: 84 Pages: 461-465

    • Peer Reviewed
  • [Journal Article] Puumala virus infection in Syrian hamsters (Mesocricetus auratus)resembling hantavirus infection in natural rodent hosts2011

    • Author(s)
      Sanada T, Kariwa H, Yoshimatsu K, Arikawa J, Yoshii K
    • Journal Title

      Virus Res

      Volume: 160 Pages: 108-119

    • Peer Reviewed
  • [Journal Article] Construction of a replicon and an infectious cDNA clone of the Sofjin strain of the Far-Eastern subtype of tick-borne encephalitis virus2011

    • Author(s)
      Takano A, Yoshii K, Kariwa H
    • Journal Title

      Arch Virol

      Volume: 156 Pages: 1931-1941

    • Peer Reviewed
  • [Journal Article] Glycosylation of the Envelope Protein of West Nile Virus Affects Its Replication in Chicks2011

    • Author(s)
      Totani M, Yoshii K, Kariwa H and Takashima I
    • Journal Title

      Avian Diseases

      Volume: 55 Pages: 561-568

    • Peer Reviewed
  • [Journal Article] Needle-free jet injection of DNA and protein vaccine of the Far-Eastern subtype of Tick-borne encephalitis virus induced protective immunity in mice2011

    • Author(s)
      Omori-Urabe Y, Yoshii K, Kariwa H
    • Journal Title

      Microbiol Immunol

      Volume: 55 Pages: 893-897

    • Peer Reviewed
  • [Journal Article] ダニ媒介性脳炎2011

    • Author(s)
      苅和宏明、好井健太朗、高島郁夫
    • Journal Title

      公衆衛生

      Volume: 75 Pages: 36-38

  • [Journal Article] 日本国内におけるダニ媒介性脳炎の血清疫学調査2011

    • Author(s)
      好井健太朗、持舘景太、 苅和宏明、高島郁夫
    • Journal Title

      獣医畜産新報

      Volume: 64 Pages: 801-803

  • [Journal Article] Glycosylation of the West Nile Virus envelope protein increases in vivo and in vitro viral multiplication in birds2010

    • Author(s)
      Murata R, Yoshii K, Kariwa H
    • Journal Title

      Am J Trop Med Hyg

      Volume: 82 Pages: 696-704

    • Peer Reviewed
  • [Journal Article] ダニ媒介性脳炎2010

    • Author(s)
      好井健太朗、苅和宏明、高島郁
    • Journal Title

      北海道獣医師会雑誌4

      Volume: 54 Pages: 2-7

  • [Journal Article] ウエストナイルウイルスの鳥類における増 殖性と極東ロシアでの抗体調査2010

    • Author(s)
      村田亮、好井健太朗、苅和宏明、高島郁夫
    • Journal Title

      獣医畜産新報

      Volume: 63 Pages: 208-209

  • [Journal Article] Epidemiological study of hantavirus infection in the Samara Region ofEuropean Russia2009

    • Author(s)
      Kariwa H, Yoshii K, Yoshimatsu K, Arikawa J
    • Journal Title

      J Vet Med Sci

      Volume: 71 Pages: 1569-1578

    • Peer Reviewed
  • [Journal Article] Establishment of a neutralization test involving reporter gene-expressing virus-like particles of tick-borne encephalitis virus2009

    • Author(s)
      Yoshii K, Kariwa H, Takashima I
    • Journal Title

      J. Virol. Methods.

      Volume: 161 Pages: 173-176

    • Peer Reviewed
  • [Presentation] ダニ媒介性フラビウイルスの病態発現機序2012

    • Author(s)
      好井健太朗
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      グランキューブ 大阪(大阪)
    • Year and Date
      2012-11-13
  • [Presentation] ダニ媒介性フラビウイルスによる中枢神経系障害に関わるウイルス因子の同定2012

    • Author(s)
      好井健太朗ら
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学(盛岡)
    • Year and Date
      2012-09-15
  • [Presentation] Epidemiology of Hantavirus Infection in Russia and the Establishment of Animal Model for Hantavirus Infection2012

    • Author(s)
      Kariwa H, et al.
    • Organizer
      Mini-symposium on Emerging and Re-emerging Viral Diseases in Asia
    • Place of Presentation
      B-ConPlaza (Beppu)
    • Year and Date
      2012-06-20
  • [Presentation] Critical Determinant of Neurologic Disease of Tick-borne Flaviviruses2012

    • Author(s)
      Yoshii K. et al.
    • Organizer
      46th Joint Working Conference on Viral Diseases, The Japan-United States Cooperative Medical Science Program
    • Place of Presentation
      B-ConPlaza (Beppu)
    • Year and Date
      2012-06-20
  • [Presentation] Isolation and characterization of hantaviruses from wild rodents and epidemiology of hemorrhagic fever with renal syndrome in Russia2012

    • Author(s)
      Kariwa H, et al.
    • Organizer
      THE 9th JAPAN-CHINA INTERNATIONAL CONFERENCE OF VIROLOGY
    • Place of Presentation
      Hokkaido University(Sapporo)
    • Year and Date
      2012-06-13
  • [Presentation] 野生マウス由来 Oas 遺伝子座導入コンジェニックマウスにおけるダニ媒介性脳炎ウイルスの神経病原性の解 析2011

    • Author(s)
      好井健太朗ら
    • Organizer
      第152回日本獣医学会
    • Place of Presentation
      大阪府立大学(堺)
    • Year and Date
      2011-09-19
  • [Presentation] Isolation and characterization of hantaviruses from wild rodents and epidemiology of hemorrhagic fever with renal syndrome in Russia2011

    • Author(s)
      Kariwa H, et al.
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      Sapporo Convention Center(Sapporo)
    • Year and Date
      2011-09-15
  • [Presentation] Construction and characterization of chimeric virus between tick-borne encephalitis virus and Omsk hemorrhagic fever virus2011

    • Author(s)
      Yoshii K, et al.
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      Sapporo Convention Center (Sapporo)
    • Year and Date
      2011-09-15
  • [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作 成と性状解析2010

    • Author(s)
      好井健太朗、寸田祐嗣、 苅和宏明、MichaelR. Holbrook、高島郁夫
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      阿波銀ホール(徳島)
    • Year and Date
      2010-11-07
  • [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作成と性状解析2010

    • Author(s)
      好井健太朗ら
    • Organizer
      第150回日本獣医学会
    • Place of Presentation
      帯広畜産大学(帯広)
    • Year and Date
      2010-09-16
  • [Presentation] Isolation of Amur and Hantaan viruses from wild rodents and the epidemiology of hemorrhagic fever with renal syndrome in Far East Russia2010

    • Author(s)
      Kariwa H, et al.
    • Organizer
      U.S.-Japan Cooperative Medical Science Program 44th Joint Working Conference on Viral Diseases
    • Place of Presentation
      Hokkaido University (Sapporo)
    • Year and Date
      2010-06-29
  • [Presentation] Isolation of Amur and Hantaan viruses from wild rodents and the epidemiology of hemorrhagic feverwith renal syndrome in Far East Russia2010

    • Author(s)
      Kariwa H, et al.
    • Organizer
      VIII International Conference on HFRS, HPS and Hantaviruses
    • Place of Presentation
      Divani Palace Acropolis, Athens (Greece)
    • Year and Date
      2010-05-21
  • [Presentation] オムスク出血熱ウイルスの感染性cDNAの構築2009

    • Author(s)
      好井健太朗ら
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      都市センターホテル(東京)
    • Year and Date
      2009-10-26
  • [Presentation] オムスク出血熱ウイルスの感染性cDNAの構築2009

    • Author(s)
      好井健太朗ら
    • Organizer
      148回日本獣医学会学術集会
    • Place of Presentation
      とりぎん文化会館(鳥取)
    • Year and Date
      2009-09-27
  • [Presentation] Development of diagnostic methods applicable to various serotypes of hanatavorus infections2009

    • Author(s)
      Kariwa H, et al.
    • Organizer
      43rd Joint Working Conference on Viral Diseases, US-Japan Cooperative medical Science Program
    • Place of Presentation
      Wistar Institute, Philadelphia, (Pennsylvania, USA)
    • Year and Date
      2009-07-21
  • [Book] In Animal Viruses edited by A. Maeda,Transworld Research Network, Karela, India2010

    • Author(s)
      Kariwa H, Yoshii K, Yoshimatsu K, Arikawa J
    • Total Pages
      23-45
    • Publisher
      Epidemiology of hantavirus infection: Hokkaido virus and its mode of infection among the gray red-backed vole, Myodes rufocanus
  • [Book] In Animal Viruses edited by Maeda A. Transworld Research Network, Karela, India2010

    • Author(s)
      Takashima I, Kariwa H, and Shirato K.
    • Total Pages
      67-74
    • Publisher
      West Nile fever
  • [Book] In Animal Viruses edited by Maeda A. Transworld Research Network, Karela, India2010

    • Author(s)
      Yoshii K, Kariwa H, and Takashima I
    • Total Pages
      75-87
    • Publisher
      Tick-borne encephalitis.

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Published: 2014-08-29  

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