Epidemiological study on environmental and genetic factor of trichlroetylene-induced hypersensitivity

2011 Fiscal Year Final Research Report

• Project/Area Number: 21406016
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Hygiene
• Research Institution: Nagoya University
• Principal Investigator: NASU Tamie 名古屋大学, 大学院・医学系研究科, 教授 (10020794)
• Co-Investigator(Kenkyū-buntansha): KAMIJIMA Michihiro 名古屋市立大学, 大学院・医学研究科, 教授 (80281070)
• Co-Investigator(Renkei-kenkyūsha): YANAGIBA Yukie 独立行政法人労働衛生研究所, 研究員 (90467283)
• Project Period (FY): 2009 – 2011
• Keywords: トリクロロエチレン / Hypersensitivity / HLA-B* 1301 / HHV6 / TNFα / IL10 / トリクロロ酢酸 / 疫学研究

Research Abstract

We investigated trichloroethylene exposure levels, HLA-B genotypes, human herpes virus 6(HHV6) reactivation and cytokine levels(TNFαand IL10) in 82 patients with hypersensitivity and 137 healthy controls who worked factory using trichloroethylene. Frequencies of HLA-B* 1301 genotype were 55 patients(67%) in the patients, while only 8 persons(6%) in the control workers. Of 38 patients, 27 patients(71%) had HLA-B : 1301 genotype, and urinary TCA levels of 22 patients(81. 5%) exceeded biological exposure index of trichloroethylene. However, all control workers with HLA-B : 1301 genotype estimated to work under biological exposure index of trichloroethylene. Frequencies of patients with HHV6 reactivation(85%), elevations of plasma TNFα(57%) and IL10(85. 3%) were significantly higher in the patients group than control workers(14. 5, 14. 5 and 3. 6%, respectively).

Research Products

• [Journal Article] Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARα-Humanized Mice (2010)
  • Author(s): Ramdhan DH, Kamijima M, Wang D, Ito Y, Naito H, Yanagiba Y, Hayashi Y, TanakaN, Aoyama T, Gonzalez FJ, Nakajima T.
  • Journal Title: Environ Health Perspect Volume: 118 Pages: 1557-1563
  • Peer Reviewed
• [Presentation] モルモットを用いたトリクロロエチレンによる皮膚・肝障害のメカニズム解析 (2012)
  • Author(s): 内藤久雄、日比野優衣、斉藤優、王棟、趙娜、宋向栄、王海蘭、上島通浩、那須民江
  • Organizer: 第85回日本産業衛生学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2012-05-31
• [Presentation] トリクロロエチレン曝露による免疫性肝障害に関する研究 (2012)
  • Author(s): 日比野優衣、内藤久雄、斉藤優、王棟、趙娜、宋向栄、王海蘭、上島通浩、那須民江.
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都、京都大学
  • Year and Date: 2012-03-25
• [Presentation] DIFFERENTIAL RESPONSE TOTRICHLOROETHYLENE-INDUCEDHEPATOSTEATOSIS IN WILD-TYPEAND PPARA-HUMANIZED MICE (2010)
  • Author(s): Ramdhan DH, Kamijima M, Wang D, Ito Y, Yanagiba Y, Hayashi Y, Naito H, Gonzalez FJ, Nakajima T.
  • Organizer: XII International Congress of Toxicology
  • Place of Presentation: Barcelona-Spain Palau de Congressosde Barcelona
  • Year and Date: 20100719-23
• [Presentation] トリクロロエチレン誘発性肝障害におけるPPARα活性の種差による影響について (2010)
  • Author(s): Ramdhan DH,上島通浩,王棟,伊藤由起,柳場由絵,林由美,内藤久雄, Gonzalez FJ,那須民江
  • Organizer: 第83回日本産業衛生学会総会
  • Place of Presentation: 福井、福井国際交流会館
  • Year and Date: 2010-05-28
• [Presentation] トリクロロエチレンによる全身性皮膚ー肝障害の背景 (2009)
  • Author(s): 那須民江
  • Organizer: 第79回日本衛生学会総会
  • Place of Presentation: 東京北里大学白金キャンパス
  • Year and Date: 2009-03-30
• [Presentation] トリクロロエチレンによる全身性皮膚肝障害ではヒトヘルペスウイルス6型が再活性化する (2009)
  • Author(s): 上島通浩
  • Organizer: 第79回日本衛生学会総会
  • Place of Presentation: 東京北里大学白金キャンパス
  • Year and Date: 2009-03-30
• [Presentation] HHV6バリアントと再活性化 (2009)
  • Author(s): 柳場由絵
  • Organizer: 第79回日本衛生学会総会
  • Place of Presentation: 東京北里大学白金キャンパス
  • Year and Date: 2009-03-30